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Electrical activation of spinal neural circuits: application to motor-system neural prostheses.

Publication ,  Journal Article
Grill, WM
Published in: Neuromodulation : journal of the International Neuromodulation Society
April 2000

Present motor-system neural prostheses use electrical activation of last-order (motor) neurons to restore function. We are pursuing a new approach: restoration of function by electrical activation of higher-order interneurons. Our hypothesis is that electrical activation of spinal neural circuits, rather than direct activation of last-order motoneurons, will simplify generation of complex motor behaviors. We review two approaches to control bladder function and to control skeletal motor function: intraspinal microstimulation for direct activation of spinal neurons and peripheral afferent stimulation for indirect, synaptic activation of spinal neurons. The results demonstrate that electrical activation of spinal neural circuits allows generation of complex motor behaviors including micturition and organized multi-joint motor responses with a single electrode. Electrical activation of spinal neural circuits, and generation of the complex functions they subserve, holds great promise to advance the function of motor system neural prostheses.

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Published In

Neuromodulation : journal of the International Neuromodulation Society

DOI

EISSN

1525-1403

ISSN

1094-7159

Publication Date

April 2000

Volume

3

Issue

2

Start / End Page

97 / 106

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
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Grill, W. M. (2000). Electrical activation of spinal neural circuits: application to motor-system neural prostheses. Neuromodulation : Journal of the International Neuromodulation Society, 3(2), 97–106. https://doi.org/10.1046/j.1525-1403.2000.00097.x
Grill, W. M. “Electrical activation of spinal neural circuits: application to motor-system neural prostheses.Neuromodulation : Journal of the International Neuromodulation Society 3, no. 2 (April 2000): 97–106. https://doi.org/10.1046/j.1525-1403.2000.00097.x.
Grill WM. Electrical activation of spinal neural circuits: application to motor-system neural prostheses. Neuromodulation : journal of the International Neuromodulation Society. 2000 Apr;3(2):97–106.
Grill, W. M. “Electrical activation of spinal neural circuits: application to motor-system neural prostheses.Neuromodulation : Journal of the International Neuromodulation Society, vol. 3, no. 2, Apr. 2000, pp. 97–106. Epmc, doi:10.1046/j.1525-1403.2000.00097.x.
Grill WM. Electrical activation of spinal neural circuits: application to motor-system neural prostheses. Neuromodulation : journal of the International Neuromodulation Society. 2000 Apr;3(2):97–106.
Journal cover image

Published In

Neuromodulation : journal of the International Neuromodulation Society

DOI

EISSN

1525-1403

ISSN

1094-7159

Publication Date

April 2000

Volume

3

Issue

2

Start / End Page

97 / 106

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences