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Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs.

Publication ,  Journal Article
Pappas, T; Debas, HT; Walsh, JH; Rivier, J; Taché, Y
Published in: Am J Physiol
January 1986

Calcitonin gene-related peptide (CGRP) is a 37-residue peptide recently characterized in the brain and found in high concentrations in the gut, particularly in the stomach and pancreas. The effects of intravenous infusion of human and rat CGRP (260 pmol . kg-1 . h-1) on gastric secretion and emptying and pancreatic exocrine secretion were studied in conscious dogs. CGRP inhibited by 60-75% gastric acid secretion stimulated by a meal, sham feeding, or step doses of bombesin but did not modify acid response to step doses of histamine or bethanechol. The inhibitory effect of CGRP is not due to blockage of postprandial or bombesin-stimulated gastrin release. CGRP did not influence basal or meal-stimulated pancreatic exocrine secretion or the rate of gastric emptying of a saline meal. These results indicate that CGRP is a potent and selective inhibitor of gastrin-mediated acid secretion in dogs and, under these conditions, did not alter other gastrointestinal functions such as gastric emptying or pancreatic exocrine secretion.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1986

Volume

250

Issue

1 Pt 1

Start / End Page

G127 / G133

Location

United States

Related Subject Headings

  • Rats
  • Pancreas
  • Nerve Tissue Proteins
  • Humans
  • Histamine
  • Gastrins
  • Gastric Emptying
  • Gastric Acid
  • Food
  • Dose-Response Relationship, Drug
 

Citation

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Pappas, T., Debas, H. T., Walsh, J. H., Rivier, J., & Taché, Y. (1986). Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs. Am J Physiol, 250(1 Pt 1), G127–G133. https://doi.org/10.1152/ajpgi.1986.250.1.G127
Pappas, T., H. T. Debas, J. H. Walsh, J. Rivier, and Y. Taché. “Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs.Am J Physiol 250, no. 1 Pt 1 (January 1986): G127–33. https://doi.org/10.1152/ajpgi.1986.250.1.G127.
Pappas T, Debas HT, Walsh JH, Rivier J, Taché Y. Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs. Am J Physiol. 1986 Jan;250(1 Pt 1):G127–33.
Pappas, T., et al. “Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs.Am J Physiol, vol. 250, no. 1 Pt 1, Jan. 1986, pp. G127–33. Pubmed, doi:10.1152/ajpgi.1986.250.1.G127.
Pappas T, Debas HT, Walsh JH, Rivier J, Taché Y. Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs. Am J Physiol. 1986 Jan;250(1 Pt 1):G127–G133.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

January 1986

Volume

250

Issue

1 Pt 1

Start / End Page

G127 / G133

Location

United States

Related Subject Headings

  • Rats
  • Pancreas
  • Nerve Tissue Proteins
  • Humans
  • Histamine
  • Gastrins
  • Gastric Emptying
  • Gastric Acid
  • Food
  • Dose-Response Relationship, Drug