Scholars@Duke

Measuring cellular structure at submicrometer scale with light scattering spectroscopy

Publication ,  Journal Article
Backman, V; Gopal, V; Kalashnikov, M; Badizadegan, K; Gurjar, R; Wax, A; Georgakoudi, I; Mueller, M; Boone, CW; Dasari, RR; Feld, MS
Published in: IEEE Journal on Selected Topics in Quantum Electronics
November 1, 2001
Published version (DOI)

We present a novel instrument for imaging the angular distributions of light backscattered by biological cells and tissues. The intensities in different regions of the image are due to scatterers of different sizes. We exploit this to study scattering from particles smaller than the wavelength of light used, even when they are mixed with larger particles. We show that the scattering from subcellular structure in both normal and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects, and propose that the distribution of scattering objects may be different in normal versus cancerous cells.

Duke Scholars

Adam P. Wax
Author Adam P. Wax Biomedical Engineering
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Published In

IEEE Journal on Selected Topics in Quantum Electronics

DOI

10.1109/2944.983289

ISSN

1077-260X

Publication Date

November 1, 2001

Volume

7

Issue

6

Start / End Page

887 / 893

Related Subject Headings

  • Optoelectronics & Photonics
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4008 Electrical engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics
 

Citation

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Backman, V., Gopal, V., Kalashnikov, M., Badizadegan, K., Gurjar, R., Wax, A., … Feld, M. S. (2001). Measuring cellular structure at submicrometer scale with light scattering spectroscopy. IEEE Journal on Selected Topics in Quantum Electronics, 7(6), 887–893. https://doi.org/10.1109/2944.983289
Backman, V., V. Gopal, M. Kalashnikov, K. Badizadegan, R. Gurjar, A. Wax, I. Georgakoudi, et al. “Measuring cellular structure at submicrometer scale with light scattering spectroscopy.” IEEE Journal on Selected Topics in Quantum Electronics 7, no. 6 (November 1, 2001): 887–93. https://doi.org/10.1109/2944.983289.
Backman V, Gopal V, Kalashnikov M, Badizadegan K, Gurjar R, Wax A, et al. Measuring cellular structure at submicrometer scale with light scattering spectroscopy. IEEE Journal on Selected Topics in Quantum Electronics. 2001 Nov 1;7(6):887–93.
Backman, V., et al. “Measuring cellular structure at submicrometer scale with light scattering spectroscopy.” IEEE Journal on Selected Topics in Quantum Electronics, vol. 7, no. 6, Nov. 2001, pp. 887–93. Scopus, doi:10.1109/2944.983289.
Backman V, Gopal V, Kalashnikov M, Badizadegan K, Gurjar R, Wax A, Georgakoudi I, Mueller M, Boone CW, Dasari RR, Feld MS. Measuring cellular structure at submicrometer scale with light scattering spectroscopy. IEEE Journal on Selected Topics in Quantum Electronics. 2001 Nov 1;7(6):887–893.

Published In

IEEE Journal on Selected Topics in Quantum Electronics

DOI

10.1109/2944.983289

ISSN

1077-260X

Publication Date

November 1, 2001

Volume

7

Issue

6

Start / End Page

887 / 893

Related Subject Headings

  • Optoelectronics & Photonics
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4008 Electrical engineering
  • 0906 Electrical and Electronic Engineering
  • 0206 Quantum Physics
  • 0205 Optical Physics