Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates.
Publication
, Journal Article
Murud, KM; Larsen, RH; Hoff, P; Zalutsky, MR
Published in: Nucl Med Biol
May 1999
A method is described for preparing 211At- and radioiodinated amidobisphosphonates. The active esters N-succinimidyl 3-(tri-methylstannyl) benzoate (ATE) and N-succinimidyl 5-(tri-methylstannyl)-3-pyridinecarboxylate (SPC) were used as precursors. The isolated and purified radiolabeled intermediates were coupled to 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APB) in high yields ranging from 60% to 97%. The lipophilicity of the compounds was found to depend on the nature of the labeled template and the halogen. High in vitro stability in mouse, fetal calf, and human serum was documented by high performance liquid chromatography.
Duke Scholars
Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
May 1999
Volume
26
Issue
4
Start / End Page
397 / 403
Location
United States
Related Subject Headings
- Solubility
- Nuclear Medicine & Medical Imaging
- Mice
- Isotope Labeling
- Iodine Radioisotopes
- Humans
- Drug Stability
- Diphosphonates
- Bone and Bones
- Astatine
Citation
APA
Chicago
ICMJE
MLA
NLM
Murud, K. M., Larsen, R. H., Hoff, P., & Zalutsky, M. R. (1999). Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates. Nucl Med Biol, 26(4), 397–403. https://doi.org/10.1016/s0969-8051(98)00119-x
Murud, K. M., R. H. Larsen, P. Hoff, and M. R. Zalutsky. “Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates.” Nucl Med Biol 26, no. 4 (May 1999): 397–403. https://doi.org/10.1016/s0969-8051(98)00119-x.
Murud KM, Larsen RH, Hoff P, Zalutsky MR. Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates. Nucl Med Biol. 1999 May;26(4):397–403.
Murud, K. M., et al. “Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates.” Nucl Med Biol, vol. 26, no. 4, May 1999, pp. 397–403. Pubmed, doi:10.1016/s0969-8051(98)00119-x.
Murud KM, Larsen RH, Hoff P, Zalutsky MR. Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates. Nucl Med Biol. 1999 May;26(4):397–403.
Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
May 1999
Volume
26
Issue
4
Start / End Page
397 / 403
Location
United States
Related Subject Headings
- Solubility
- Nuclear Medicine & Medical Imaging
- Mice
- Isotope Labeling
- Iodine Radioisotopes
- Humans
- Drug Stability
- Diphosphonates
- Bone and Bones
- Astatine