Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen.
Publication
, Journal Article
Zalutsky, MR; Bast, RC; Knapp, RC
Published in: Int J Rad Appl Instrum B
1989
The pharmacokinetics of 131I-labeled OC 125 F(ab')2 antibody fragment were investigated in athymic mice bearing OVCAR-3 ovarian carcinoma xenografts, a model in which the CA 125 antigen is present in serum. Nine antibody doses between 0.1 and 650 micrograms were studied. Optimal tumor to normal tissue ratios were obtained at 100-200 micrograms of F(ab')2. At most antibody doses, the pre-injection level of circulating CA 125 appeared to influence the localization of 131I activity in tumor, liver and spleen.
Duke Scholars
Published In
Int J Rad Appl Instrum B
DOI
ISSN
0883-2897
Publication Date
1989
Volume
16
Issue
4
Start / End Page
405 / 411
Location
England
Related Subject Headings
- Transplantation, Heterologous
- Tissue Distribution
- Radionuclide Imaging
- Ovarian Neoplasms
- Neoplasm Transplantation
- Mice
- Iodine Radioisotopes
- Immunoglobulin Fab Fragments
- Humans
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Zalutsky, M. R., Bast, R. C., & Knapp, R. C. (1989). Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Int J Rad Appl Instrum B, 16(4), 405–411. https://doi.org/10.1016/0883-2897(89)90108-6
Zalutsky, M. R., R. C. Bast, and R. C. Knapp. “Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen.” Int J Rad Appl Instrum B 16, no. 4 (1989): 405–11. https://doi.org/10.1016/0883-2897(89)90108-6.
Zalutsky MR, Bast RC, Knapp RC. Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Int J Rad Appl Instrum B. 1989;16(4):405–11.
Zalutsky, M. R., et al. “Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen.” Int J Rad Appl Instrum B, vol. 16, no. 4, 1989, pp. 405–11. Pubmed, doi:10.1016/0883-2897(89)90108-6.
Zalutsky MR, Bast RC, Knapp RC. Pharmacokinetics of a radioiodinated monoclonal antibody F(ab')2 fragment in a xenograft model with circulating antigen. Int J Rad Appl Instrum B. 1989;16(4):405–411.
Published In
Int J Rad Appl Instrum B
DOI
ISSN
0883-2897
Publication Date
1989
Volume
16
Issue
4
Start / End Page
405 / 411
Location
England
Related Subject Headings
- Transplantation, Heterologous
- Tissue Distribution
- Radionuclide Imaging
- Ovarian Neoplasms
- Neoplasm Transplantation
- Mice
- Iodine Radioisotopes
- Immunoglobulin Fab Fragments
- Humans
- Female