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Use of liposomes as carriers for radiation synovectomy.

Publication ,  Journal Article
Zalutsky, MR; Noska, MA; Gallagher, PW; Shortkroff, S; Sledge, CB
Published in: Int J Rad Appl Instrum B
1988
Published version (DOI) Link to item

Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.

Duke Scholars

Michael Rod Zalutsky
Author Michael Rod Zalutsky Radiology

Published In

Int J Rad Appl Instrum B

DOI

10.1016/0883-2897(88)90081-5

ISSN

0883-2897

Publication Date

1988

Volume

15

Issue

2

Start / End Page

151 / 156

Location

England

Related Subject Headings

  • Tissue Distribution
  • Synovial Membrane
  • Sphingomyelins
  • Sodium Pertechnetate Tc 99m
  • Rabbits
  • Phosphatidylcholines
  • Permeability
  • Oxyquinoline
  • Organometallic Compounds
  • Liposomes
 

Citation

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ICMJE
MLA
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Zalutsky, M. R., Noska, M. A., Gallagher, P. W., Shortkroff, S., & Sledge, C. B. (1988). Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B, 15(2), 151–156. https://doi.org/10.1016/0883-2897(88)90081-5
Zalutsky, M. R., M. A. Noska, P. W. Gallagher, S. Shortkroff, and C. B. Sledge. “Use of liposomes as carriers for radiation synovectomy.” Int J Rad Appl Instrum B 15, no. 2 (1988): 151–56. https://doi.org/10.1016/0883-2897(88)90081-5.
Zalutsky MR, Noska MA, Gallagher PW, Shortkroff S, Sledge CB. Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B. 1988;15(2):151–6.
Zalutsky, M. R., et al. “Use of liposomes as carriers for radiation synovectomy.” Int J Rad Appl Instrum B, vol. 15, no. 2, 1988, pp. 151–56. Pubmed, doi:10.1016/0883-2897(88)90081-5.
Zalutsky MR, Noska MA, Gallagher PW, Shortkroff S, Sledge CB. Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B. 1988;15(2):151–156.

Published In

Int J Rad Appl Instrum B

DOI

10.1016/0883-2897(88)90081-5

ISSN

0883-2897

Publication Date

1988

Volume

15

Issue

2

Start / End Page

151 / 156

Location

England

Related Subject Headings

  • Tissue Distribution
  • Synovial Membrane
  • Sphingomyelins
  • Sodium Pertechnetate Tc 99m
  • Rabbits
  • Phosphatidylcholines
  • Permeability
  • Oxyquinoline
  • Organometallic Compounds
  • Liposomes