Scholars@Duke publication: Use of liposomes as carriers for radiation synovectomy.

Use of liposomes as carriers for radiation synovectomy.

Publication , Journal Article

Zalutsky, MR; Noska, MA; Gallagher, PW; Shortkroff, S; Sledge, CB

Published in: Int J Rad Appl Instrum B

1988

Using [99mTc]pertechnetate as an aqueous space marker, the permeability of liposomes composed of seven different mixtures of distearoylphosphatidylcholine (DSPC) and sphingomyelin (SM) was determined. Liposomes containing 20-33% SM were the least permeable in the presence of rheumatoid synovial fluid. Following injection of 99mTc-containing liposomes into the knee joints of rabbits, retention of 99mTc in the knee was more than 200 times greater than following injection of nonencapsulated [99mTc]pertechnetate. The knee clearance biologic half time of 99mTc with DSPC/SM (4:1) liposomes was 64 h. Most of the activity that had leaked from the knee was not found in extra-articular tissues, suggesting rapid excretion. When DSPC/SM (4:1) liposomes were labeled with 111In(oxine), a knee clearance biologic half time of greater than 1200 h was observed.

Duke Scholars

Author Michael Rod Zalutsky Radiology

Published In

Int J Rad Appl Instrum B

DOI

10.1016/0883-2897(88)90081-5

ISSN

0883-2897

Publication Date

1988

Volume

Issue

Start / End Page

151 / 156

Location

England

Related Subject Headings

Tissue Distribution
Synovial Membrane
Sphingomyelins
Sodium Pertechnetate Tc 99m
Rabbits
Phosphatidylcholines
Permeability
Oxyquinoline
Organometallic Compounds
Liposomes

Citation

APA

Chicago

ICMJE

MLA

NLM

Zalutsky, M. R., Noska, M. A., Gallagher, P. W., Shortkroff, S., & Sledge, C. B. (1988). Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B, 15(2), 151–156. https://doi.org/10.1016/0883-2897(88)90081-5

Zalutsky, M. R., M. A. Noska, P. W. Gallagher, S. Shortkroff, and C. B. Sledge. “Use of liposomes as carriers for radiation synovectomy.” Int J Rad Appl Instrum B 15, no. 2 (1988): 151–56. https://doi.org/10.1016/0883-2897(88)90081-5.

Zalutsky MR, Noska MA, Gallagher PW, Shortkroff S, Sledge CB. Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B. 1988;15(2):151–6.

Zalutsky, M. R., et al. “Use of liposomes as carriers for radiation synovectomy.” Int J Rad Appl Instrum B, vol. 15, no. 2, 1988, pp. 151–56. Pubmed, doi:10.1016/0883-2897(88)90081-5.

Zalutsky MR, Noska MA, Gallagher PW, Shortkroff S, Sledge CB. Use of liposomes as carriers for radiation synovectomy. Int J Rad Appl Instrum B. 1988;15(2):151–156.

Published In

Int J Rad Appl Instrum B

DOI

10.1016/0883-2897(88)90081-5

ISSN

0883-2897

Publication Date

1988

Volume

Issue

Start / End Page

151 / 156

Location

England

Related Subject Headings

Tissue Distribution
Synovial Membrane
Sphingomyelins
Sodium Pertechnetate Tc 99m
Rabbits
Phosphatidylcholines
Permeability
Oxyquinoline
Organometallic Compounds
Liposomes