Prokaryotic transcription regulators: more than just the helix-turn-helix motif.
Publication
, Journal Article
Huffman, JL; Brennan, RG
Published in: Curr Opin Struct Biol
February 2002
Over the past two years, the structures of many prokaryotic transcriptional regulators have been solved, and several of them have revealed the structural mechanism of gene regulation. The crystal structure of BmrR-TPP-DNA reveals a novel mechanism of transcription activation, whereby the drug-bound protein activates the bmr promoter by local DNA unwinding and base pair disruption. Myristoyl-CoA induces FadR by a three-helix pushing mechanism, whereas TetR employs a helical pendulum motion to regulate expression. The structures of AbrB, and DNA complexes of Rob and MuR unveil a novel DNA-binding motif, 'the looped-hinge helix', and new uses of the helix-turn-helix and winged helix motifs in DNA binding.
Duke Scholars
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Published In
Curr Opin Struct Biol
DOI
ISSN
0959-440X
Publication Date
February 2002
Volume
12
Issue
1
Start / End Page
98 / 106
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Trans-Activators
- Repressor Proteins
- Protein Folding
- Protein Conformation
- Prokaryotic Cells
- Models, Molecular
- Helix-Turn-Helix Motifs
- Gene Expression Regulation, Bacterial
Citation
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ICMJE
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Huffman, J. L., & Brennan, R. G. (2002). Prokaryotic transcription regulators: more than just the helix-turn-helix motif. Curr Opin Struct Biol, 12(1), 98–106. https://doi.org/10.1016/s0959-440x(02)00295-6
Huffman, Joy L., and Richard G. Brennan. “Prokaryotic transcription regulators: more than just the helix-turn-helix motif.” Curr Opin Struct Biol 12, no. 1 (February 2002): 98–106. https://doi.org/10.1016/s0959-440x(02)00295-6.
Huffman JL, Brennan RG. Prokaryotic transcription regulators: more than just the helix-turn-helix motif. Curr Opin Struct Biol. 2002 Feb;12(1):98–106.
Huffman, Joy L., and Richard G. Brennan. “Prokaryotic transcription regulators: more than just the helix-turn-helix motif.” Curr Opin Struct Biol, vol. 12, no. 1, Feb. 2002, pp. 98–106. Pubmed, doi:10.1016/s0959-440x(02)00295-6.
Huffman JL, Brennan RG. Prokaryotic transcription regulators: more than just the helix-turn-helix motif. Curr Opin Struct Biol. 2002 Feb;12(1):98–106.
Published In
Curr Opin Struct Biol
DOI
ISSN
0959-440X
Publication Date
February 2002
Volume
12
Issue
1
Start / End Page
98 / 106
Location
England
Related Subject Headings
- Transcription, Genetic
- Transcription Factors
- Trans-Activators
- Repressor Proteins
- Protein Folding
- Protein Conformation
- Prokaryotic Cells
- Models, Molecular
- Helix-Turn-Helix Motifs
- Gene Expression Regulation, Bacterial