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Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.

Publication ,  Journal Article
Zhang, P; Wu, J; Deoliveira, D; Chao, NJ; Chen, BJ
Published in: Biol Blood Marrow Transplant
October 2012

We studied whether allospecific CD4(+) effector memory T cells (T(EM)) could induce graft-versus-host disease (GVHD) using a novel GVHD model induced solely by CD4(+) T cell receptor transgenic TEa cells. Allospecific T(EM) generated in a lymphopenic host bore a typical memory phenotype. Moreover, these cells were able to elicit a faster and more effective proliferative response on challenge with alloantigen in vitro and to mediate "second-set" skin graft rejection in vivo. However, these allospecific T(EM) were unable to induce GVHD. Allospecific T(EM) recipients became tolerant to alloantigen as a result of clonal deletion. Even though allospecific T(EM) were able to respond to alloantigen initially, the expansion of these cells and inflammatory cytokine production during GVHD were dramatically decreased. The inability of allospecific T(EM) to sustain the alloresponse may be a result of enhanced activation-induced cell death. These observations provide insight into how allospecific CD4(+) T(EM) respond to alloantigen during GVHD and underscore the fundamental differences in alloresponses mediated by allospecific T(EM) in graft rejection and GVHD settings.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

October 2012

Volume

18

Issue

10

Start / End Page

1488 / 1499

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Skin Transplantation
  • Receptors, Antigen, T-Cell
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Isoantigens
  • Immunology
  • Immunologic Memory
  • Graft vs Host Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, P., Wu, J., Deoliveira, D., Chao, N. J., & Chen, B. J. (2012). Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. Biol Blood Marrow Transplant, 18(10), 1488–1499. https://doi.org/10.1016/j.bbmt.2012.07.009
Zhang, Ping, Jieying Wu, Divino Deoliveira, Nelson J. Chao, and Benny J. Chen. “Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.Biol Blood Marrow Transplant 18, no. 10 (October 2012): 1488–99. https://doi.org/10.1016/j.bbmt.2012.07.009.
Zhang P, Wu J, Deoliveira D, Chao NJ, Chen BJ. Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. Biol Blood Marrow Transplant. 2012 Oct;18(10):1488–99.
Zhang, Ping, et al. “Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.Biol Blood Marrow Transplant, vol. 18, no. 10, Oct. 2012, pp. 1488–99. Pubmed, doi:10.1016/j.bbmt.2012.07.009.
Zhang P, Wu J, Deoliveira D, Chao NJ, Chen BJ. Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. Biol Blood Marrow Transplant. 2012 Oct;18(10):1488–1499.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

October 2012

Volume

18

Issue

10

Start / End Page

1488 / 1499

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Skin Transplantation
  • Receptors, Antigen, T-Cell
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
  • Isoantigens
  • Immunology
  • Immunologic Memory
  • Graft vs Host Disease