Jun Chen | Scholars@Duke

Jun Chen
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996

Contact Information

Box 103866 Med Ctr, Durham, NC 27710
GSRB1 Rm 4004B, 905 S Lasalle Street, Durham, NC 27710
chen0032@mc.duke.edu (919) 681-3021

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Stanford University School of Medicine 1994 - 1996
- M.D., Sun Yat Sen University (China) 1991
Duke Appointment History
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016 - 2017
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2006 - 2011
- Assistant Research Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2003 - 2006
- Assistant Research Professor of Medicine, Medicine, Medical Oncology, Medicine 2002 - 2003
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Piryani, Sadhna O., Yiqun Jiao, Angel Y. F. Kam, Yang Liu, Tuan Vo-Dinh, Benny J. Chen, Nelson J. Chao, and Phuong L. Doan. “Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury..” Int J Radiat Oncol Biol Phys 104, no. 2 (June 1, 2019): 291–301. https://doi.org/10.1016/j.ijrobp.2019.02.008.
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  - Huang, Wei, Wenjian Mo, Jieling Jiang, Nelson J. Chao, and Benny J. Chen. “Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease..” Front Immunol 10 (2019). https://doi.org/10.3389/fimmu.2019.00624.
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  - Liu, Yang, Wei Huang, Chuanfeng Xiong, Yuxian Huang, Benny J. Chen, Luigi Racioppi, Nelson Chao, and Tuan Vo-Dinh. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars..” Int J Nanomedicine 14 (2019): 3403–11. https://doi.org/10.2147/IJN.S192189.
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  - Poe, Jonathan C., Wei Jia, Julie A. Di Paolo, Nancy J. Reyes, Ji Yun Kim, Hsuan Su, John S. Sundy, et al. “SYK inhibitor entospletinib prevents ocular and skin GVHD in mice..” Jci Insight 3, no. 19 (October 4, 2018). https://doi.org/10.1172/jci.insight.122430.
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  - Piryani, Sadhna O., Angel Y. F. Kam, Evelyna G. Kliassov, Benny J. Chen, Neil L. Spector, John P. Chute, David S. Hsu, Nelson J. Chao, and Phuong L. Doan. “Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration..” Stem Cells 36, no. 2 (February 2018): 252–64. https://doi.org/10.1002/stem.2731.
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  - Sundaramoorthy, Pasupathi, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao, and Yubin Kang. “Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice..” Stem Cell Res Ther 8, no. 1 (November 15, 2017). https://doi.org/10.1186/s13287-017-0711-2.
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  - Foster, Mary H., Elizabeth S. Buckley, Benny J. Chen, Kwan-Ki Hwang, and Amy G. Clark. “Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen..” Mol Immunol 76 (August 2016): 123–33. https://doi.org/10.1016/j.molimm.2016.07.004.
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  - Zhang, Baojun, Jianxuan Wu, Yiqun Jiao, Cheryl Bock, Meifang Dai, Benny Chen, Nelson Chao, Weiguo Zhang, and Yuan Zhuang. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells..” J Immunol 195, no. 9 (November 1, 2015): 4282–91. https://doi.org/10.4049/jimmunol.1501220.
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  - Worni-Schudel, Inge M., Amy G. Clark, Tiffany Chien, Kwan-Ki Hwang, Benny J. Chen, and Mary H. Foster. “Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models..” J Transl Med 13 (June 6, 2015). https://doi.org/10.1186/s12967-015-0539-4.
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  - Macintyre, Andrew N., Valerie A. Gerriets, Amanda G. Nichols, Ryan D. Michalek, Michael C. Rudolph, Divino Deoliveira, Steven M. Anderson, et al. “The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function..” Cell Metab 20, no. 1 (July 1, 2014): 61–72. https://doi.org/10.1016/j.cmet.2014.05.004.
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  - Belley, Matthew D., Chu Wang, Giao Nguyen, Rathnayaka Gunasingha, Nelson J. Chao, Benny J. Chen, Mark W. Dewhirst, and Terry T. Yoshizumi. “Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators..” Med Phys 41, no. 3 (March 2014). https://doi.org/10.1118/1.4864237.
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  - Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Zhiguo Li, Nelson J. Chao, and Benny J. Chen. “Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation..” Int J Radiat Oncol Biol Phys 85, no. 4 (March 15, 2013): 1141–48. https://doi.org/10.1016/j.ijrobp.2012.08.014.
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  - Chen, Benny J., Yiqun Jiao, Ping Zhang, Albert Y. Sun, Geoffrey S. Pitt, Divino Deoliveira, Nicholas Drago, Tong Ye, Chen Liu, and Nelson J. Chao. “Long-term in vivo imaging of multiple organs at the single cell level..” Plos One 8, no. 1 (2013). https://doi.org/10.1371/journal.pone.0052087.
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  - Zhang, Ping, Jieying Wu, Divino Deoliveira, Nelson J. Chao, and Benny J. Chen. “Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice..” Biol Blood Marrow Transplant 18, no. 10 (October 2012): 1488–99. https://doi.org/10.1016/j.bbmt.2012.07.009.
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  - Zhang, Jifeng, Brice E. Barefoot, Wenjian Mo, Divino Deoliveira, Jessica Son, Xiuyu Cui, Elizabeth Ramsburg, and Benny J. Chen. “CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice..” Blood 119, no. 26 (June 28, 2012): 6344–53. https://doi.org/10.1182/blood-2011-03-342055.
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  - Deoliveira, Divino, Yiqun Jiao, Joel R. Ross, Kayla Corbin, Qizhen Xiao, Greta Toncheva, Colin Anderson-Evans, Terry T. Yoshizumi, Benny J. Chen, and Nelson J. Chao. “An ear punch model for studying the effect of radiation on wound healing..” Int J Radiat Biol 87, no. 8 (August 2011): 869–77. https://doi.org/10.3109/09553002.2011.568575.
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  - Zhang, Ping, Benny J. Chen, and Nelson J. Chao. “Prevention of GVHD without losing GVL effect: windows of opportunity..” Immunol Res 49, no. 1–3 (April 2011): 49–55. https://doi.org/10.1007/s12026-010-8193-7.
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  - Liu, Congxiao, Benny J. Chen, Divinomar Deoliveira, Gregory D. Sempowski, Nelson J. Chao, and Robert W. Storms. “Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation..” Blood 116, no. 25 (December 16, 2010): 5518–27. https://doi.org/10.1182/blood-2009-12-260810.
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  - Kang, Yubin, Benny J. Chen, Divino Deoliveira, Jeffrey Mito, and Nelson J. Chao. “Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model..” Plos One 5, no. 6 (June 28, 2010). https://doi.org/10.1371/journal.pone.0011316.
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  - Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates..” Plos One 5, no. 6 (June 16, 2010). https://doi.org/10.1371/journal.pone.0011056.
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  - Palmer, J. M., B. J. Chen, D. DeOliveira, N. -. D. Le, and N. J. Chao. “Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cells..” Bone Marrow Transplant 45, no. 2 (February 2010): 379–84. https://doi.org/10.1038/bmt.2009.140.
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  - Yan, Bin, Huili Wang, Donghua Xie, Nobuko Wakamatsu, Mitchell S. Anscher, Mark W. Dewhirst, Ron E. J. Mitchel, Benny J. Chen, and Chuan-Yuan Li. “Increased skin carcinogenesis in caspase-activated DNase knockout mice..” Carcinogenesis 30, no. 10 (October 2009): 1776–80. https://doi.org/10.1093/carcin/bgp146.
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  - Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis..” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
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  - Salter, Alice B., Sarah K. Meadows, Garrett G. Muramoto, Heather Himburg, Phuong Doan, Pamela Daher, Lauren Russell, Benny Chen, Nelson J. Chao, and John P. Chute. “Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo..” Blood 113, no. 9 (February 26, 2009): 2104–7. https://doi.org/10.1182/blood-2008-06-162941.
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  - Chen, Benny J. “Allogeneic memory T cell response..” Biol Blood Marrow Transplant 14, no. 1 Suppl 1 (January 2008): 20–22.
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  - Garantziotis, Stavros, Scott M. Palmer, Laurie D. Snyder, Tonya Ganous, Benny J. Chen, Tie Wang, Donald N. Cook, and David A. Schwartz. “Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide..” Transplantation 84, no. 8 (October 27, 2007): 1012–19. https://doi.org/10.1097/01.tp.0000286040.85007.89.
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  - Fu, Dan, Tong Ye, Thomas E. Matthews, Benny J. Chen, Gunay Yurtserver, and Warren S. Warren. “High-resolution in vivo imaging of blood vessels without labeling..” Optics Letters 32, no. 18 (September 2007): 2641–43. https://doi.org/10.1364/ol.32.002641.
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  - Chen, Benny J., Divino Deoliveira, Xiuyu Cui, Ngocdiep T. Le, Jessica Son, John F. Whitesides, and Nelson J. Chao. “Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse..” Blood 109, no. 7 (April 1, 2007): 3115–23. https://doi.org/10.1182/blood-2006-04-016410.
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  - Chute, John P., Garrett G. Muramoto, Alice B. Salter, Sarah K. Meadows, Dennis W. Rickman, Benny Chen, Heather A. Himburg, and Nelson J. Chao. “Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice..” Blood 109, no. 6 (March 15, 2007): 2365–72. https://doi.org/10.1182/blood-2006-05-022640.
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  - Chen, B. J. “Treg-cell expansion: Better to be "naive".” Blood 108, no. 13 (December 15, 2006): 3963–64. https://doi.org/10.1182/blood-2006-09-048447.
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  - Muramoto, Garrett G., Benny Chen, Xiuyu Cui, Nelson J. Chao, and John P. Chute. “Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury..” Biol Blood Marrow Transplant 12, no. 5 (May 2006): 530–40. https://doi.org/10.1016/j.bbmt.2005.12.039.
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  - Chao, Nelson J., and Benny J. Chen. “Prophylaxis and treatment of acute graft-versus-host disease..” Semin Hematol 43, no. 1 (January 2006): 32–41. https://doi.org/10.1053/j.seminhematol.2005.09.007.
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  - Hollingsworth, John W., Benny J. Chen, David M. Brass, Katie Berman, M Dee Gunn, Donald N. Cook, and David A. Schwartz. “The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation..” Am J Respir Crit Care Med 171, no. 8 (April 15, 2005): 806–13. https://doi.org/10.1164/rccm.200407-953OC.
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  - Le, N. T., B. J. Chen, and N. J. Chao. “Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting..” Cytotherapy 7, no. 2 (2005): 126–33. https://doi.org/10.1080/14653240510018163.
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  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Jos Domen, and Nelson J. Chao. “Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation..” Blood 103, no. 11 (June 1, 2004): 4344–52. https://doi.org/10.1182/blood-2003-07-2534.
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  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Congxiao Liu, and Nelson J. Chao. “Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease..” Blood 103, no. 4 (February 15, 2004): 1534–41. https://doi.org/10.1182/blood-2003-08-2987.
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  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, and Nelson J. Chao. “Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice..” Experimental Hematology 31, no. 10 (October 2003): 953–58. https://doi.org/10.1016/s0301-472x(03)00196-6.
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  - Chen, Benny J., Xiuyu Cui, Congxiao Liu, and Nelson J. Chao. “Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process..” Blood 99, no. 9 (May 1, 2002): 3083–88. https://doi.org/10.1182/blood.v99.9.3083.
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  - Chen, B. J., and N. J. Chao. “Immunosuppressive and antiinflammatory effects of triptolide and its prodrug PG-490-88.” Drugs of the Future 27, no. 1 (March 26, 2002): 57–60. https://doi.org/10.1358/dof.2002.027.01.647608.
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  - Chen, Benny J., Xiuyu Cui, and Nelson J. Chao. “Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation..” Blood 99, no. 6 (March 15, 2002): 2235–40. https://doi.org/10.1182/blood.v99.6.2235.
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  - Chen, Benny J., Yanfei Chen, Xiuyu Cui, John M. Fidler, and Nelson J. Chao. “Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model..” Transplantation 73, no. 1 (January 15, 2002): 115–21. https://doi.org/10.1097/00007890-200201150-00022.
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  - Chao, Nelson J., Cong X. Liu, Barbara Rooney, Benny J. Chen, Gwynn D. Long, James J. Vredenburgh, Ashley Morris, Cristina Gasparetto, and David A. Rizzieri. “Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells..” Biol Blood Marrow Transplant 8, no. 5 (2002): 249–56.
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  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Maria E. Gooding, Congxiao Liu, Barton F. Haynes, and Nelson J. Chao. “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution..” Blood 99, no. 1 (January 1, 2002): 364–71. https://doi.org/10.1182/blood.v99.1.364.
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  - Chen, B. J. “Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F..” Leuk Lymphoma 42, no. 3 (July 2001): 253–65. https://doi.org/10.3109/10428190109064582.
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  - Klein, A. K., D. D. Patel, M. E. Gooding, G. D. Sempowski, B. J. Chen, C. Liu, J. Kurtzberg, B. F. Haynes, and N. J. Chao. “T-Cell recovery in adults and children following umbilical cord blood transplantation..” Biol Blood Marrow Transplant 7, no. 8 (2001): 454–66.
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  - Chen, B. J., X. Cui, J. M. Fidler, and N. J. Chao. “Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.” Blood 96, no. 11 PART II (December 1, 2000).
  - Chen, B. J., X. Cui, and N. J. Chao. “Addition of stem cells from allogeneic donors accelerates engraftment and immune reconstitution after stem cell transplantation.” Blood 96, no. 11 PART I (December 1, 2000).
  - Chen, B. J., C. Liu, X. Cui, J. M. Fidler, and N. J. Chao. “Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion..” Transplantation 70, no. 10 (November 27, 2000): 1442–47. https://doi.org/10.1097/00007890-200011270-00008.
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  - Chen, B. J., R. E. Morris, and N. J. Chao. “Graft-versus-host disease prevention by rapamycin: cellular mechanisms..” Biol Blood Marrow Transplant 6, no. 5A (2000): 529–36.
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  - Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo..” Proc Natl Acad Sci U S A 93, no. 10 (May 14, 1996): 5061–66. https://doi.org/10.1073/pnas.93.10.5061.
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  - Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “Erratum: A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules (Proceedings of the National Academy of Science of the United States of America (May 14, 1996) 93:10 (5061-5066)).” Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (January 1, 1996).
- Conference Papers
  - Agboola, Olabunmi, Jun Chen, and M Louise Markert. “Thymus Transplantation for Chronic Graft Versus Host Disease.” In Journal of Allergy and Clinical Immunology, 139:AB185–AB185. Elsevier BV, 2017. https://doi.org/10.1016/j.jaci.2016.12.605.
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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Publications

Academic Articles

Conference Papers