Jun Chen | Scholars@Duke

Jun Chen
Professor of Medicine

Current Appointments & Affiliations

Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

Box 103866 Med Ctr, Durham, NC 27710
GSRB1 Rm 4004B, 905 S Lasalle Street, Durham, NC 27710
chen0032@mc.duke.edu (919) 681-3021

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Stanford University, School of Medicine 1994 - 1996
- M.D., Sun Yat Sen University (China) 1991
Previous Appointments & Affiliations
- Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2021 - 2022
- Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2020
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2019 - 2020
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2018 - 2020
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2017 - 2019
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2016 - 2018
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2015 - 2017
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Basic Science Departments 2016 - 2017
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2014 - 2016
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013 - 2015
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2012 - 2014
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011 - 2013
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011 - 2012
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2010 - 2011
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2009 - 2011
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2008 - 2010
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2007 - 2009
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2006 - 2008
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2006 - 2007
- Assistant Research Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2004 - 2006
- Assistant Research Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2003 - 2005
- Assistant Research Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2003 - 2004
- Assistant Research Professor of Medicine, Medicine, Medical Oncology, Medicine 2002 - 2003
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Holmes, Zachary C., Helen Tang, Congxiao Liu, Amy T. Bush, Benjamin C. Neubert, Yiqun Jiao, Megan Covington, et al. “Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease.” Blood, August 5, 2022. https://doi.org/10.1182/blood.2021015178.
    Full Text Link to Item
  - Chen, Benny J. “Chronic GVHD of the CNS.” Blood 139, no. 9 (March 3, 2022): 1271–72. https://doi.org/10.1182/blood.2021014079.
    Full Text Link to Item
  - Huang, Ying, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, et al. “Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect.” Front Immunol 13 (2022): 751296. https://doi.org/10.3389/fimmu.2022.751296.
    Full Text Link to Item
  - Su, Hsuan, Kazuhiro Imai, Wei Jia, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Phuong L. Doan, and Stefanie Sarantopoulos. “Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens.” Front Immunol 13 (2022): 865486. https://doi.org/10.3389/fimmu.2022.865486.
    Full Text Open Access Copy Link to Item
  - Jia, Wei, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, et al. “BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.” Blood 137, no. 18 (May 6, 2021): 2544–57. https://doi.org/10.1182/blood.2020008040.
    Full Text Link to Item
  - Maung, Ko K., Benny J. Chen, Ian Barak, Zhiguo Li, David A. Rizzieri, Cristina Gasparetto, Keith M. Sullivan, et al. “Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation.” Bone Marrow Transplant 56, no. 1 (January 2021): 137–43. https://doi.org/10.1038/s41409-020-0991-5.
    Full Text Link to Item
  - Sung, Anthony D., Richard C. Yen, Yiqun Jiao, Alyssa Bernanke, Deborah A. Lewis, Sara E. Miller, Zhiguo Li, et al. “Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenia-Related Bleeding.” Radiat Res 194, no. 2 (August 1, 2020): 162–72. https://doi.org/10.1667/RADE-20-00016.
    Full Text Link to Item
  - Zou, Yujing, and Benny J. Chen. “T cell metabolism in graft-versus-host disease.” Blood Sci 2, no. 1 (January 2020): 16–21. https://doi.org/10.1097/BS9.0000000000000035.
    Full Text Link to Item
  - Tang, Yuning J., Jianguo Huang, Hidetoshi Tsushima, Ga I. Ban, Hongyuan Zhang, Kristianne M. Oristian, Vijitha Puviindran, et al. “Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.” Cell Rep 28, no. 11 (September 10, 2019): 2837-2850.e5. https://doi.org/10.1016/j.celrep.2019.08.029.
    Full Text Link to Item
  - Piryani, Sadhna O., Yiqun Jiao, Angel Y. F. Kam, Yang Liu, Tuan Vo-Dinh, Benny J. Chen, Nelson J. Chao, and Phuong L. Doan. “Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury.” Int J Radiat Oncol Biol Phys 104, no. 2 (June 1, 2019): 291–301. https://doi.org/10.1016/j.ijrobp.2019.02.008.
    Full Text Link to Item
  - Huang, Wei, Wenjian Mo, Jieling Jiang, Nelson J. Chao, and Benny J. Chen. “Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease.” Front Immunol 10 (2019): 624. https://doi.org/10.3389/fimmu.2019.00624.
    Full Text Link to Item
  - Liu, Yang, Wei Huang, Chuanfeng Xiong, Yuxian Huang, Benny J. Chen, Luigi Racioppi, Nelson Chao, and Tuan Vo-Dinh. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.” Int J Nanomedicine 14 (2019): 3403–11. https://doi.org/10.2147/IJN.S192189.
    Full Text Link to Item
  - Poe, Jonathan C., Wei Jia, Julie A. Di Paolo, Nancy J. Reyes, Ji Yun Kim, Hsuan Su, John S. Sundy, et al. “SYK inhibitor entospletinib prevents ocular and skin GVHD in mice.” Jci Insight 3, no. 19 (October 4, 2018). https://doi.org/10.1172/jci.insight.122430.
    Full Text Link to Item
  - Piryani, Sadhna O., Angel Y. F. Kam, Evelyna G. Kliassov, Benny J. Chen, Neil L. Spector, John P. Chute, David S. Hsu, Nelson J. Chao, and Phuong L. Doan. “Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration.” Stem Cells 36, no. 2 (February 2018): 252–64. https://doi.org/10.1002/stem.2731.
    Full Text Link to Item
  - Sundaramoorthy, Pasupathi, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao, and Yubin Kang. “Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice.” Stem Cell Res Ther 8, no. 1 (November 15, 2017): 263. https://doi.org/10.1186/s13287-017-0711-2.
    Full Text Link to Item
  - Foster, Mary H., Elizabeth S. Buckley, Benny J. Chen, Kwan-Ki Hwang, and Amy G. Clark. “Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen.” Mol Immunol 76 (August 2016): 123–33. https://doi.org/10.1016/j.molimm.2016.07.004.
    Full Text Link to Item
  - Zhang, Baojun, Jianxuan Wu, Yiqun Jiao, Cheryl Bock, Meifang Dai, Benny Chen, Nelson Chao, Weiguo Zhang, and Yuan Zhuang. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.” J Immunol 195, no. 9 (November 1, 2015): 4282–91. https://doi.org/10.4049/jimmunol.1501220.
    Full Text Link to Item
  - Worni-Schudel, Inge M., Amy G. Clark, Tiffany Chien, Kwan-Ki Hwang, Benny J. Chen, and Mary H. Foster. “Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models.” J Transl Med 13 (June 6, 2015): 185. https://doi.org/10.1186/s12967-015-0539-4.
    Full Text Link to Item
  - Macintyre, Andrew N., Valerie A. Gerriets, Amanda G. Nichols, Ryan D. Michalek, Michael C. Rudolph, Divino Deoliveira, Steven M. Anderson, et al. “The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.” Cell Metab 20, no. 1 (July 1, 2014): 61–72. https://doi.org/10.1016/j.cmet.2014.05.004.
    Full Text Link to Item
  - Belley, Matthew D., Chu Wang, Giao Nguyen, Rathnayaka Gunasingha, Nelson J. Chao, Benny J. Chen, Mark W. Dewhirst, and Terry T. Yoshizumi. “Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators.” Med Phys 41, no. 3 (March 2014): 034101. https://doi.org/10.1118/1.4864237.
    Full Text Link to Item
  - Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Zhiguo Li, Nelson J. Chao, and Benny J. Chen. “Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation.” Int J Radiat Oncol Biol Phys 85, no. 4 (March 15, 2013): 1141–48. https://doi.org/10.1016/j.ijrobp.2012.08.014.
    Full Text Link to Item
  - Chen, Benny J., Yiqun Jiao, Ping Zhang, Albert Y. Sun, Geoffrey S. Pitt, Divino Deoliveira, Nicholas Drago, Tong Ye, Chen Liu, and Nelson J. Chao. “Long-term in vivo imaging of multiple organs at the single cell level.” Plos One 8, no. 1 (2013): e52087. https://doi.org/10.1371/journal.pone.0052087.
    Full Text Link to Item
  - Zhang, Ping, Jieying Wu, Divino Deoliveira, Nelson J. Chao, and Benny J. Chen. “Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice.” Biol Blood Marrow Transplant 18, no. 10 (October 2012): 1488–99. https://doi.org/10.1016/j.bbmt.2012.07.009.
    Full Text Link to Item
  - Zhang, Jifeng, Brice E. Barefoot, Wenjian Mo, Divino Deoliveira, Jessica Son, Xiuyu Cui, Elizabeth Ramsburg, and Benny J. Chen. “CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.” Blood 119, no. 26 (June 28, 2012): 6344–53. https://doi.org/10.1182/blood-2011-03-342055.
    Full Text Link to Item
  - Deoliveira, Divino, Yiqun Jiao, Joel R. Ross, Kayla Corbin, Qizhen Xiao, Greta Toncheva, Colin Anderson-Evans, Terry T. Yoshizumi, Benny J. Chen, and Nelson J. Chao. “An ear punch model for studying the effect of radiation on wound healing.” Int J Radiat Biol 87, no. 8 (August 2011): 869–77. https://doi.org/10.3109/09553002.2011.568575.
    Full Text Link to Item
  - Zhang, Ping, Benny J. Chen, and Nelson J. Chao. “Prevention of GVHD without losing GVL effect: windows of opportunity.” Immunol Res 49, no. 1–3 (April 2011): 49–55. https://doi.org/10.1007/s12026-010-8193-7.
    Full Text Link to Item
  - Liu, Congxiao, Benny J. Chen, Divinomar Deoliveira, Gregory D. Sempowski, Nelson J. Chao, and Robert W. Storms. “Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation.” Blood 116, no. 25 (December 16, 2010): 5518–27. https://doi.org/10.1182/blood-2009-12-260810.
    Full Text Link to Item
  - Kang, Yubin, Benny J. Chen, Divino Deoliveira, Jeffrey Mito, and Nelson J. Chao. “Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model.” Plos One 5, no. 6 (June 28, 2010): e11316. https://doi.org/10.1371/journal.pone.0011316.
    Full Text Open Access Copy Link to Item
  - Chen, Benny J., Divino Deoliveira, Ivan Spasojevic, Gregory D. Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, et al. “Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates.” Plos One 5, no. 6 (June 16, 2010): e11056. https://doi.org/10.1371/journal.pone.0011056.
    Full Text Open Access Copy Link to Item
  - Palmer, J. M., B. J. Chen, D. DeOliveira, N. -. D. Le, and N. J. Chao. “Novel mechanism of rapamycin in GVHD: increase in interstitial regulatory T cells.” Bone Marrow Transplant 45, no. 2 (February 2010): 379–84. https://doi.org/10.1038/bmt.2009.140.
    Full Text Link to Item
  - Yan, Bin, Huili Wang, Donghua Xie, Nobuko Wakamatsu, Mitchell S. Anscher, Mark W. Dewhirst, Ron E. J. Mitchel, Benny J. Chen, and Chuan-Yuan Li. “Increased skin carcinogenesis in caspase-activated DNase knockout mice.” Carcinogenesis 30, no. 10 (October 2009): 1776–80. https://doi.org/10.1093/carcin/bgp146.
    Full Text Link to Item
  - Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
    Full Text Link to Item
  - Salter, Alice B., Sarah K. Meadows, Garrett G. Muramoto, Heather Himburg, Phuong Doan, Pamela Daher, Lauren Russell, Benny Chen, Nelson J. Chao, and John P. Chute. “Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.” Blood 113, no. 9 (February 26, 2009): 2104–7. https://doi.org/10.1182/blood-2008-06-162941.
    Full Text Link to Item
  - Chen, Benny J. “Allogeneic memory T cell response.” Biology of Blood and Marrow Transplantation 14, no. 1 (January 1, 2008): 20–22.
    Link to Item
  - Chen, Benny J. “Allogeneic memory T cell response.” Biol Blood Marrow Transplant 14, no. 1 Suppl 1 (January 2008): 20–22.
    Link to Item
  - Garantziotis, Stavros, Scott M. Palmer, Laurie D. Snyder, Tonya Ganous, Benny J. Chen, Tie Wang, Donald N. Cook, and David A. Schwartz. “Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide.” Transplantation 84, no. 8 (October 27, 2007): 1012–19. https://doi.org/10.1097/01.tp.0000286040.85007.89.
    Full Text Link to Item
  - Fu, Dan, Tong Ye, Thomas E. Matthews, Benny J. Chen, Gunay Yurtserver, and Warren S. Warren. “High-resolution in vivo imaging of blood vessels without labeling.” Opt Lett 32, no. 18 (September 15, 2007): 2641–43. https://doi.org/10.1364/ol.32.002641.
    Full Text Link to Item
  - Chen, Benny J., Divino Deoliveira, Xiuyu Cui, Ngocdiep T. Le, Jessica Son, John F. Whitesides, and Nelson J. Chao. “Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse.” Blood 109, no. 7 (April 1, 2007): 3115–23. https://doi.org/10.1182/blood-2006-04-016410.
    Full Text Link to Item
  - Chute, John P., Garrett G. Muramoto, Alice B. Salter, Sarah K. Meadows, Dennis W. Rickman, Benny Chen, Heather A. Himburg, and Nelson J. Chao. “Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice.” Blood 109, no. 6 (March 15, 2007): 2365–72. https://doi.org/10.1182/blood-2006-05-022640.
    Full Text Link to Item
  - Chen, B. J. “Treg-cell expansion: Better to be "naive".” Blood 108, no. 13 (December 15, 2006): 3963–64. https://doi.org/10.1182/blood-2006-09-048447.
    Full Text
  - Muramoto, Garrett G., Benny Chen, Xiuyu Cui, Nelson J. Chao, and John P. Chute. “Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury.” Biol Blood Marrow Transplant 12, no. 5 (May 2006): 530–40. https://doi.org/10.1016/j.bbmt.2005.12.039.
    Full Text Link to Item
  - Chao, Nelson J., and Benny J. Chen. “Prophylaxis and treatment of acute graft-versus-host disease.” Semin Hematol 43, no. 1 (January 2006): 32–41. https://doi.org/10.1053/j.seminhematol.2005.09.007.
    Full Text Link to Item
  - Hollingsworth, John W., Benny J. Chen, David M. Brass, Katie Berman, M Dee Gunn, Donald N. Cook, and David A. Schwartz. “The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.” Am J Respir Crit Care Med 171, no. 8 (April 15, 2005): 806–13. https://doi.org/10.1164/rccm.200407-953OC.
    Full Text Link to Item
  - Le, N. T., B. J. Chen, and N. J. Chao. “Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting.” Cytotherapy 7, no. 2 (2005): 126–33. https://doi.org/10.1080/14653240510018163.
    Full Text Link to Item
  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Jos Domen, and Nelson J. Chao. “Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation.” Blood 103, no. 11 (June 1, 2004): 4344–52. https://doi.org/10.1182/blood-2003-07-2534.
    Full Text Link to Item
  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Congxiao Liu, and Nelson J. Chao. “Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.” Blood 103, no. 4 (February 15, 2004): 1534–41. https://doi.org/10.1182/blood-2003-08-2987.
    Full Text Link to Item
  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, and Nelson J. Chao. “Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.” Exp Hematol 31, no. 10 (October 2003): 953–58. https://doi.org/10.1016/s0301-472x(03)00196-6.
    Full Text Link to Item
  - Chen, Benny J., Xiuyu Cui, Congxiao Liu, and Nelson J. Chao. “Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process.” Blood 99, no. 9 (May 1, 2002): 3083–88. https://doi.org/10.1182/blood.v99.9.3083.
    Full Text Link to Item
  - Chen, B. J., and N. J. Chao. “Immunosuppressive and antiinflammatory effects of triptolide and its prodrug PG-490-88.” Drugs of the Future 27, no. 1 (March 26, 2002): 57–60. https://doi.org/10.1358/dof.2002.027.01.647608.
    Full Text
  - Chen, Benny J., Xiuyu Cui, and Nelson J. Chao. “Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation.” Blood 99, no. 6 (March 15, 2002): 2235–40. https://doi.org/10.1182/blood.v99.6.2235.
    Full Text Link to Item
  - Chen, Benny J., Yanfei Chen, Xiuyu Cui, John M. Fidler, and Nelson J. Chao. “Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.” Transplantation 73, no. 1 (January 15, 2002): 115–21. https://doi.org/10.1097/00007890-200201150-00022.
    Full Text Link to Item
  - Chao, Nelson J., Cong X. Liu, Barbara Rooney, Benny J. Chen, Gwynn D. Long, James J. Vredenburgh, Ashley Morris, Cristina Gasparetto, and David A. Rizzieri. “Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells.” Biol Blood Marrow Transplant 8, no. 5 (2002): 249–56. https://doi.org/10.1053/bbmt.2002.v8.pm12064361.
    Full Text Link to Item
  - Chen, Benny J., Xiuyu Cui, Gregory D. Sempowski, Maria E. Gooding, Congxiao Liu, Barton F. Haynes, and Nelson J. Chao. “A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.” Blood 99, no. 1 (January 1, 2002): 364–71. https://doi.org/10.1182/blood.v99.1.364.
    Full Text Link to Item
  - Chen, B. J. “Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.” Leuk Lymphoma 42, no. 3 (July 2001): 253–65. https://doi.org/10.3109/10428190109064582.
    Full Text Link to Item
  - Klein, A. K., D. D. Patel, M. E. Gooding, G. D. Sempowski, B. J. Chen, C. Liu, J. Kurtzberg, B. F. Haynes, and N. J. Chao. “T-Cell recovery in adults and children following umbilical cord blood transplantation.” Biol Blood Marrow Transplant 7, no. 8 (2001): 454–66. https://doi.org/10.1016/s1083-8791(01)80013-6.
    Full Text Link to Item
  - Chen, B. J., X. Cui, J. M. Fidler, and N. J. Chao. “Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model.” Blood 96, no. 11 PART II (December 1, 2000).
  - Chen, B. J., X. Cui, and N. J. Chao. “Addition of stem cells from allogeneic donors accelerates engraftment and immune reconstitution after stem cell transplantation.” Blood 96, no. 11 PART I (December 1, 2000).
  - Chen, B. J., C. Liu, X. Cui, J. M. Fidler, and N. J. Chao. “Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion.” Transplantation 70, no. 10 (November 27, 2000): 1442–47. https://doi.org/10.1097/00007890-200011270-00008.
    Full Text Link to Item
  - Chen, B. J., R. E. Morris, and N. J. Chao. “Graft-versus-host disease prevention by rapamycin: cellular mechanisms.” Biol Blood Marrow Transplant 6, no. 5A (2000): 529–36. https://doi.org/10.1016/s1083-8791(00)70062-0.
    Full Text Link to Item
  - Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.” Proc Natl Acad Sci U S A 93, no. 10 (May 14, 1996): 5061–66. https://doi.org/10.1073/pnas.93.10.5061.
    Full Text Link to Item
  - Schlegel, P. G., R. Aharoni, Y. Chen, J. Chen, D. Teitelbaum, R. Arnon, M. Sela, and N. J. Chao. “Erratum: A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules (Proceedings of the National Academy of Science of the United States of America (May 14, 1996) 93:10 (5061-5066)).” Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (January 1, 1996): 8796.
- Conference Papers
  - Xiong, Chuanfeng, Wei Huang, Xiaoli Nie, Ying Huang, Yiqun Jiao, Yujing Zou, Charles Huang, et al. “Microrna-191 Regulates T-Cell Clonal Expansion during Graft-Versus-Host Disease.” In Blood, 134:4433–4433. American Society of Hematology, 2019. https://doi.org/10.1182/blood-2019-130179.
    Full Text
  - Maung, Ko Ko, Benny J. Chen, David A. Rizzieri, Cristina Gasparetto, Keith Sullivan, Gwynn D. Long, Ashley Morris Engemann, et al. “Phase I, Dose Escalation Study of Naive T-Cell Depleted Donor Lymphocyte Infusion Following Allogeneic Stem Cell Transplantation.” In Biology of Blood and Marrow Transplantation, Vol. 25, 2019.
    Link to Item
  - Piryani, Sadhna O., Yiqun Jiao, Angel Y. F. Kam, Yang Liu, Tuan Vo-Dinh, Benny J. Chen, Nelson J. Chao, and Phuong L. Doan. “Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury.” In Blood, 132:2581–2581. American Society of Hematology, 2018. https://doi.org/10.1182/blood-2018-99-117058.
    Full Text
  - Huang, Ying, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Michael Choi, Andrew N. Macintyre, et al. “Role of Glucose Transporter 1 in Graft-Versus-Host Disease and Graft-Versus-Tumor Effect.” In Blood, Vol. 130. AMER SOC HEMATOLOGY, 2017.
    Link to Item
  - Agboola, Olabunmi, Jun Chen, and M Louise Markert. “Thymus Transplantation for Chronic Graft Versus Host Disease.” In Journal of Allergy and Clinical Immunology, 139:AB185–AB185. Elsevier BV, 2017. https://doi.org/10.1016/j.jaci.2016.12.605.
    Full Text
  - Jia, Wei, Jonathan C. Poe, Hsuan Su, Glenn K. Matsushima, Jeffrey Rathmell, Kazuhiro Imai, Nancy J. Reyes, et al. “Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd.” In Blood, 128:498–498. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.498.498.
    Full Text
  - Piryani, Sadhna O., Angel Y. F. Kam, Evelyna G. Kliassov, Benny J. Chen, Neil L. Spector, John P. Chute, Nelson J. Chao, and Phuong L. Doan. “EGF Accelerates Hematopoietic Stem Cell Regeneration Following 5-FU Chemotherapy Via G-CSF Receptor Signaling.” In Blood, 128:1490–1490. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.1490.1490.
    Full Text
  - Poe, Jonathan C., Wei Jia, Hsuan Su, Zhiguo Li, Frances T. Hakim, Steven Z. Pavletic, Jeremy J. Rose, et al. “All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients.” In Blood, 128:669–669. American Society of Hematology, 2016. https://doi.org/10.1182/blood.v128.22.669.669.
    Full Text
  - Poe, Jonathan C., Wei Jia, Zhiguo Li, Frances T. Hakim, Steven Z. Pavletic, Jeremy J. Rose, David A. Rizzieri, et al. “Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD).” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
    Link to Item
  - Sung, Anthony D., Richard Yen, Divino Deoliveira, Yiqun Jiao, Sadhna Piryani, Alyssa Bernanke, Sharon Hall, et al. “Fibrinogen-Coated Nanospheres Prevent Thrombocytopenia-Related Bleeding.” In Biology of Blood and Marrow Transplantation, 21:S111–13. Elsevier BV, 2015. https://doi.org/10.1016/j.bbmt.2014.11.140.
    Full Text
  - Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Nelson J. Chao, and Benny J. Chen. “Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation.” In Biology of Blood and Marrow Transplantation, 19:S198–S198. Elsevier BV, 2013. https://doi.org/10.1016/j.bbmt.2012.11.214.
    Full Text
  - Jiao, Yiqun, Ping Zhang, Divino DeOliveira, Nicholas Drago, Nelson J. Chao, and Benny J. Chen. “An Ear-Tissue Model for High-Resolution In Vivo Imaging.” In Blood, 116:623–623. AMER SOC HEMATOLOGY, 2010.
    Link to Item
  - Zhang, Jifeng, Divino DeOliveira, Jessica Son, Xiuyu Cui, Nelson J. Chao, and Benny J. Chen. “Allogeneic Effector Memory T Cells Enhance Hematopoietic Engraftment and Immune Reconstitution After Stem Cell Transplantation.” In Blood, 116:41–41. AMER SOC HEMATOLOGY, 2010.
    Link to Item
  - Chen, B. J., J. Nishimura, J. Wei, D. Deoliveira, R. P. Rother, J. Hollingsworth, and N. J. Chao. “Blockade Of Two Independent Innate Immunity Pathways Synergistically Prevent Lethal Graft-Versus-Host Disease.” In Biology of Blood and Marrow Transplantation, 16:S299–S299. Elsevier BV, 2010. https://doi.org/10.1016/j.bbmt.2009.12.429.
    Full Text
  - Chen, Benny J., Divino Deoliveira, Jeff Mito, and Nelson J. Chao. “Plerixafor (Mozobil (R)) Selectively Enhances Donor Hematopoietic Cell Engraftment.” In Blood, 114:155–155. AMER SOC HEMATOLOGY, 2009.
    Link to Item
  - Zhang, Ping, Jieying Wu, Divino Deoliveria, Nelson J. Chao, and Benny J. Chen. “Allospecific Effector Memory T Cells Are Able to Mediate Second-Set Skin Graft Rejection but Unable to Induce Graft-Versus-Host Disease.” In Blood, 114:100–100. AMER SOC HEMATOLOGY, 2009.
    Link to Item
  - Liu, C., D. DeOliveira, G. D. Sempowski, N. J. Chao, B. J. Chen, and R. W. Storms. “Complete Long-Term Hematopoietic Engraftment by Lineage-Depleted ALDH CD34+ UCB Cells.” In Biology of Blood and Marrow Transplantation, 15:85–85. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.265.
    Full Text
  - Zheng, Q., D. Deoliveira, N. J. Chao, and B. J. Chen. “Human Memory T CELL S Elicit Decreased Cytotoxicity Against Allogeneic Targets.” In Biology of Blood and Marrow Transplantation, 15:120–120. Elsevier BV, 2009. https://doi.org/10.1016/j.bbmt.2008.12.370.
    Full Text
  - Chen, Benny J., Divino Deoliveira, and Nelson Chao. “Insulin-Like Growth Factor 1 Protects against Lethal Irradiation.” In Blood, 112:1196–1196. AMER SOC HEMATOLOGY, 2008.
    Link to Item
  - Chen, B. J., J. Wu, D. DeOliveira, and N. J. Chao. “366: Allospecific Effector Memory T cells have Decreased Ability to Induce Acute GVHD.” In Biology of Blood and Marrow Transplantation, 14:134–134. Elsevier BV, 2008. https://doi.org/10.1016/j.bbmt.2007.12.376.
    Full Text
  - Palmer, J. M., B. J. Chen, D. DeOliviera, N. Le, and N. J. Chao. “342: Rapamycin Prevents GVHD in Mouse Model through Novel Mechanism: Increase in Regulatory T cells.” In Biology of Blood and Marrow Transplantation, 14:126–126. Elsevier BV, 2008. https://doi.org/10.1016/j.bbmt.2007.12.352.
    Full Text
  - Chen, Benny J., Divino Deoliveira, and Nelson J. Chao. “Allogeneic Committed Hematopoietic Progenitors Are Protective Against Radiation.” In Blood, 110:4871–4871. American Society of Hematology, 2007. https://doi.org/10.1182/blood.v110.11.4871.4871.
    Full Text
  - Chen, B. J., D. Deoliveira, and N. J. Chao. “345: Radioprotection by growth hormone.” In Biology of Blood and Marrow Transplantation, 13:125–125. Elsevier BV, 2007. https://doi.org/10.1016/j.bbmt.2006.12.350.
    Full Text
  - Chen, Benny J., Divino Deoliveira, and Nelson J. Chao. “In Vivo Radiaprotective Effects of Growth Hormone.” In Blood, 108:5158–5158. American Society of Hematology, 2006. https://doi.org/10.1182/blood.v108.11.5158.5158.
    Full Text
  - Chen, B. J., D. DeOliveria, X. Cui, and N. J. Chao. “Failure of memory T cells to induce GVHD is a result of an abortive alloresponse.” In Biology of Blood and Marrow Transplantation, 12:68–68. Elsevier BV, 2006. https://doi.org/10.1016/j.bbmt.2005.11.214.
    Full Text
  - Chen, B. J., J. Son, X. Cui, and N. J. Chao. “Mature T cells alone separate GVL from GVHD: The need for better controls.” In Biology of Blood and Marrow Transplantation, 11:48–49. Elsevier BV, 2005. https://doi.org/10.1016/j.bbmt.2004.12.143.
    Full Text
  - Chen, B. J., X. Y. Cui, J. Son, and N. J. Chao. “Promotion of stem cell-derived new T cell generation by CD62L-memory T cells requires alloantigen recognition.” In Blood, 104:831A-831A. AMER SOC HEMATOLOGY, 2004.
    Link to Item
  - Chen, B. J., X. Y. Cui, and N. J. Chao. “Human memory T cells proliferate but do not elicit cytotoxicity in response to alloantigens.” In Blood, 104:347A-347A. AMER SOC HEMATOLOGY, 2004.
    Link to Item
  - Chen, B. J., X. Cui, J. Son, and N. J. Chao. “Non-GVHD-inducing CD62L− memory T cells promote new T cell regeneration from hematopoietic stem cells.” In Biology of Blood and Marrow Transplantation, 10:23–23. Elsevier BV, 2004. https://doi.org/10.1016/j.bbmt.2003.12.093.
    Full Text
  - Chen, B. J., X. Y. Cui, and N. J. Chao. “Addition of stem cells from allogeneic donors accelerates engraftment and immune reconstitution after stem cell transplantation.” In Blood, 96:172A-172A. AMER SOC HEMATOLOGY, 2000.
    Link to Item
  - Chen, B. J., X. Y. Cui, and N. J. Chao. “Hematopoiteic stem cell doses correlate with the speed of immune reconstitution after allogeneic stem cell transplantation.” In Blood, 96:772A-772A. AMER SOC HEMATOLOGY, 2000.
    Link to Item
  - Chen, B. J., C. X. Liu, and N. J. Chao. “Impaired immune function in murine adult cord blood recipients.” In Blood, 94:568A-568A. AMER SOC HEMATOLOGY, 1999.
    Link to Item
  - Chen, B. J., C. X. Liu, and N. J. Chao. “Reconstitution of the immunohematopoietic system in adult murine recipients across major histocompatibility complex by near-term fetal blood.” In Blood, 94:321A-321A. AMER SOC HEMATOLOGY, 1999.
    Link to Item
  - Chen, B. J., J. M. Fidler, and N. J. Chao. “Inhibition of alloreactive T cell expansion in vivo by PG490-88 results in successful prevention of graft-versus-host disease (GVHD).” In Blood, 92:291B-291B. W B SAUNDERS CO, 1998.
    Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Subject Headings

Selected Publications

Academic Articles

Conference Papers