Jun Chen | Scholars@Duke

Jun Chen
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996

Contact Information

Box 103866 Med Ctr, Durham, NC 27710
GSRB1 Rm 4004B, 905 S Lasalle Street, Durham, NC 27710
chen0032@mc.duke.edu (919) 681-3021

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Stanford University School of Medicine 1994 - 1996
- M.D., Sun Yat Sen University (China) 1991
Duke Appointment History
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016 - 2017
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2006 - 2011
- Assistant Research Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2003 - 2006
- Assistant Research Professor of Medicine, Medicine, Medical Oncology, Medicine 2002 - 2003
Expertise
Subject Headings
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Piryani, SO, Kam, AYF, Kliassov, EG, Chen, BJ, Spector, NL, Chute, JP, Hsu, DS, Chao, NJ, and Doan, PL. "Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration." Stem Cells (Dayton, Ohio) 36, no. 2 (February 2018): 252-264. Full Text
  - Sundaramoorthy, P, Wang, Q, Zheng, Z, Jiao, Y, Chen, BJ, Doan, PL, Chao, NJ, and Kang, Y. "Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice." Stem Cell Research & Therapy 8, no. 1 (November 15, 2017): 263-null. Full Text
  - Foster, MH, Buckley, ES, Chen, BJ, Hwang, K-K, and Clark, AG. "Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen." Molecular immunology 76 (August 2016): 123-133. Full Text
  - Zhang, B, Wu, J, Jiao, Y, Bock, C, Dai, M, Chen, B, Chao, N, Zhang, W, and Zhuang, Y. "Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells." Journal of immunology (Baltimore, Md. : 1950) 195, no. 9 (November 2015): 4282-4291. Full Text
  - Worni-Schudel, IM, Clark, AG, Chien, T, Hwang, K-K, Chen, BJ, and Foster, MH. "Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models." Journal of translational medicine 13 (June 6, 2015): 185-. Full Text
  - Macintyre, AN, Gerriets, VA, Nichols, AG, Michalek, RD, Rudolph, MC, Deoliveira, D, Anderson, SM, Abel, ED, Chen, BJ, Hale, LP, and Rathmell, JC. "The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function." Cell Metabolism 20, no. 1 (July 2014): 61-72. Full Text
  - Belley, MD, Wang, C, Nguyen, G, Gunasingha, R, Chao, NJ, Chen, BJ, Dewhirst, MW, and Yoshizumi, TT. "Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators." Medical physics 41, no. 3 (March 2014): 034101-. Full Text
  - Macintyre, AN, Gerriets, VA, Nichols, AG, Michalek, RD, Rudolph, MC, Deoliveira, D, Anderson, SM, Abel, ED, Chen, BJ, Hale, LP, and Rathmell, JC. "The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function." Cell Metabolism 20, no. 1 (2014): 61-72. Full Text
  - Zhou, D, Deoliveira, D, Kang, Y, Choi, SS, Li, Z, Chao, NJ, and Chen, BJ. "Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation." International Journal of Radiation Oncology, Biology, Physics 85, no. 4 (March 2013): 1141-1148. Full Text
  - Chen, BJ, Jiao, Y, Zhang, P, Sun, AY, Pitt, GS, Deoliveira, D, Drago, N, Ye, T, Liu, C, and Chao, NJ. "Long-term in vivo imaging of multiple organs at the single cell level." Plos One 8, no. 1 (January 2, 2013): e52087-null. Full Text
  - Zhou, D, Deoliveira, D, Kang, Y, Choi, SS, Li, Z, Chao, NJ, and Chen, BJ. "Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation." International Journal of Radiation Oncology Biology Physics 85, no. 4 (2013): 1141-1148. Full Text
  - Zhang, P, Wu, J, Deoliveira, D, Chao, NJ, and Chen, BJ. "Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice." Biol Blood Marrow Transplant 18, no. 10 (October 2012): 1488-1499. Full Text Link to Item
  - Zhang, J, Barefoot, BE, Mo, W, Deoliveira, D, Son, J, Cui, X, Ramsburg, E, and Chen, BJ. "CD62L ^- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice." Blood 119, no. 26 (2012): 6344-6353. Full Text
  - Deoliveira, D, Jiao, Y, Ross, JR, Corbin, K, Xiao, Q, Toncheva, G, Anderson-Evans, C, Yoshizumi, TT, Chen, BJ, and Chao, NJ. "An ear punch model for studying the effect of radiation on wound healing." Int J Radiat Biol 87, no. 8 (August 2011): 869-877. Full Text Link to Item
  - Zhang, P, Chen, BJ, and Chao, NJ. "Prevention of GVHD without losing GVL effect: windows of opportunity." Immunol Res 49, no. 1-3 (April 2011): 49-55. (Review) Full Text Link to Item
  - Liu, C, Chen, BJ, Deoliveira, D, Sempowski, GD, Chao, NJ, and Storms, RW. "Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation." Blood 116, no. 25 (December 16, 2010): 5518-5527. Full Text Link to Item
  - Chen, BJ, Deoliveira, D, Spasojevic, I, Sempowski, GD, Jiang, C, Owzar, K, Wang, X, Gesty-Palmer, D, Cline, JM, Bourland, JD, Dugan, G, Meadows, SK, Daher, P, Muramoto, G, Chute, JP, and Chao, NJ. "Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates." Plos One 5, no. 6 (June 16, 2010): e11056-null. Full Text Open Access Copy
  - Kang, Y, Chen, BJ, Deoliveira, D, Mito, J, and Chao, NJ. "Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model." PLoS ONE 5, no. 6 (2010). Full Text Open Access Copy
  - Palmer, JM, Chen, BJ, Deoliveira, D, Le, N-D, and Chao, NJ. "Novel mechanism of rapamycin in GVHD: Increase in interstitial regulatory T cells." Bone Marrow Transplantation 45, no. 2 (2010): 379-384. Full Text
  - Yan, B, Wang, H, Xie, D, Wakamatsu, N, Anscher, MS, Dewhirst, MW, Mitchel, REJ, Chen, BJ, and Li, C-Y. "Increased skin carcinogenesis in caspase-activated DNase knockout mice." Carcinogenesis 30, no. 10 (October 2009): 1776-1780. Full Text Link to Item
  - Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." The Journal of Clinical Investigation 119, no. 4 (April 2009): 943-953. Full Text
  - Salter, AB, Meadows, SK, Muramoto, GG, Himburg, H, Doan, P, Daher, P, Russell, L, Chen, B, Chao, NJ, and Chute, JP. "Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo." Blood 113, no. 9 (February 26, 2009): 2104-2107. Full Text Link to Item
  - Chen, BJ. "Allogeneic memory T cell response." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 14, no. 1 Suppl 1 (2008): 20-22.
  - Garantziotis, S, Palmer, SM, Snyder, LD, Ganous, T, Chen, BJ, Wang, T, Cook, DN, and Schwartz, DA. "Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide." Transplantation 84, no. 8 (October 2007): 1012-1019. Full Text
  - Fu, D, Ye, T, Matthews, TE, Chen, BJ, Yurtserver, G, and Warren, WS. "High-resolution in vivo imaging of blood vessels without labeling." Optics Letters 32, no. 18 (September 2007): 2641-2643. Full Text
  - Chen, BJ, Deoliveira, D, Cui, X, Le, NT, Son, J, Whitesides, JF, and Chao, NJ. "Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse." Blood 109, no. 7 (April 1, 2007): 3115-3123. Full Text Link to Item
  - Chute, JP, Muramoto, GG, Salter, AB, Meadows, SK, Rickman, DW, Chen, B, Himburg, HA, and Chao, NJ. "Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice." Blood 109, no. 6 (March 2007): 2365-2372. Full Text
  - Muramoto, GG, Chen, B, Cui, X, Chao, NJ, and Chute, JP. "Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 12, no. 5 (May 2006): 530-540. Full Text
  - Chao, NJ, and Chen, BJ. "Prophylaxis and treatment of acute graft-versus-host disease." Seminars in Hematology 43, no. 1 (January 2006): 32-41. (Review) Full Text
  - Chen, BJ. "Treg-cell expansion: Better to be "naive"." Blood 108, no. 13 (2006): 3963-3964. Full Text
  - Hollingsworth, JW, Chen, BJ, Brass, DM, Berman, K, Gunn, MD, Cook, DN, and Schwartz, DA. "The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation." American Journal of Respiratory and Critical Care Medicine 171, no. 8 (April 2005): 806-813. Full Text
  - Le, NT, Chen, BJ, and Chao, NJ. "Selective elimination of alloreactivity from immunotherapeutic T cells by photodynamic cell purging and memory T-cell sorting." Cytotherapy 7, no. 2 (2005): 126-133. (Review) Full Text Link to Item
  - Chen, BJ, Cui, X, Sempowski, GD, Domen, J, and Chao, NJ. "Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation." Blood 103, no. 11 (June 1, 2004): 4344-4352. Full Text Link to Item
  - Chen, BJ, Cui, X, Sempowski, GD, Liu, C, and Chao, NJ. "Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease." Blood 103, no. 4 (February 15, 2004): 1534-1541. Full Text Link to Item
  - Chen, BJ, Cui, X, Sempowski, GD, and Chao, NJ. "Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice." Experimental Hematology 31, no. 10 (October 2003): 953-958. Full Text
  - Chen, BJ, Cui, X, Liu, C, and Chao, NJ. "Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process." Blood 99, no. 9 (May 1, 2002): 3083-3088. Link to Item
  - Chen, BJ, Cui, X, and Chao, NJ. "Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation." Blood 99, no. 6 (March 15, 2002): 2235-2240. Link to Item
  - Chen, BJ, Chen, Y, Cui, X, Fidler, JM, and Chao, NJ. "Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model." Transplantation 73, no. 1 (January 15, 2002): 115-121. Link to Item
  - Chao, NJ, Liu, CX, Rooney, B, Chen, BJ, Long, GD, Vredenburgh, JJ, Morris, A, Gasparetto, C, and Rizzieri, DA. "Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells." Biol Blood Marrow Transplant 8, no. 5 (2002): 249-256. Link to Item
  - Chen, BJ, Cui, X, Sempowski, GD, Gooding, ME, Liu, C, Haynes, BF, and Chao, NJ. "A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution." Blood 99, no. 1 (January 1, 2002): 364-371. Link to Item
  - Chen, BJ, and Chao, NJ. "Immunosuppressive and antiinflammatory effects of triptolide and its prodrug PG-490-88." Drugs of the Future 27, no. 1 (2002): 57-60. Full Text
  - Chen, BJ. "Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F." Leukemia & Lymphoma 42, no. 3 (July 2001): 253-265. (Review) Full Text
  - Klein, AK, Patel, DD, Gooding, ME, Sempowski, GD, Chen, BJ, Liu, C, Kurtzberg, J, Haynes, BF, and Chao, NJ. "T-Cell recovery in adults and children following umbilical cord blood transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 7, no. 8 (January 2001): 454-466. Full Text
  - Chen, BJ, Liu, C, Cui, X, Fidler, JM, and Chao, NJ. "Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion." Transplantation 70, no. 10 (November 27, 2000): 1442-1447. Link to Item
  - Chen, BJ, Cui, X, Fidler, JM, and Chao, NJ. "Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model." Blood 96, no. 11 PART II (2000): 309b-.
  - Chen, BJ, Cui, X, and Chao, NJ. "Addition of stem cells from allogeneic donors accelerates engraftment and immune reconstitution after stem cell transplantation." Blood 96, no. 11 PART I (2000): 171a-.
  - Chen, BJ, Morris, RE, and Chao, NJ. "Graft-versus-host disease prevention by rapamycin: cellular mechanisms." Biol Blood Marrow Transplant 6, no. 5A (2000): 529-536. Link to Item
  - Chen, BJ, Morris, RE, and Chao, NJ. "Graft-Versus-Host Disease Prevention by Rapamycin: Cellular Mechanisms." Biology of Blood and Marrow Transplantation 6, no. 5 A (2000): 529-536.
  - Schlegel, PG, Aharoni, R, Chen, Y, Chen, J, Teitelbaum, D, Arnon, R, Sela, M, and Chao, NJ. "A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo." Proc Natl Acad Sci U S A 93, no. 10 (May 14, 1996): 5061-5066. Link to Item
  - Schlegel, PG, Aharoni, R, Chen, Y, Chen, J, Teitelbaum, D, Arnon, R, Sela, M, and Chao, NJ. "Erratum: A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules (Proceedings of the National Academy of Science of the United States of America (May 14, 1996) 93:10 (5061-5066))." Proceedings of the National Academy of Sciences of the United States of America 93, no. 16 (1996): 8796--.

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Publications

Academic Articles