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Time-lapse mapping of cortical changes in schizophrenia with different treatments.

Publication ,  Journal Article
Thompson, PM; Bartzokis, G; Hayashi, KM; Klunder, AD; Lu, PH; Edwards, N; Hong, MS; Yu, M; Geaga, JA; Toga, AW; Charles, C; Perkins, DO ...
Published in: Cereb Cortex
May 2009

Using time-lapse maps, we visualized the dynamics of schizophrenia progression, revealing spreading cortical changes that depend on the type of antipsychotic treatment. Dynamic, 4-dimensional models of disease progression were created from 4 repeated high-resolution brain magnetic resonance imaging scans of 36 first-episode schizophrenia patients (30 men/6 women; mean age: 24.2 +/- 5.1 SD years) randomized to haloperidol (HAL) (n = 15) or olanzapine (OLZ) treatment (n = 21), imaged at baseline, 3, 6, and 12 months (144 scans). Based on surface-based cortical models and point-by-point measures of gray matter volume, we generated time-lapse maps for each treatment. Disease trajectories differed for atypical versus typical neuroleptic drugs. A rapidly advancing parietal-to-frontal deficit trajectory, in HAL-treated patients, mirrored normal cortical maturation but greatly intensified. The disease trajectory advanced even after symptom normalization, involving the frontal cortex within 12 months with typical drug treatment. Areas with fastest tissue loss shifted anteriorly in the first year of psychosis. This trajectory was not seen with OLZ. Whether this association reflects either reduced neurotoxicity or neuroprotection cannot be addressed with neuroimaging; changes may relate to glial rather than neural components. These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions.

Duke Scholars

Published In

Cereb Cortex

DOI

EISSN

1460-2199

Publication Date

May 2009

Volume

19

Issue

5

Start / End Page

1107 / 1123

Location

United States

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Olanzapine
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans
  • Haloperidol
  • Female
  • Experimental Psychology
 

Citation

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Thompson, P. M., Bartzokis, G., Hayashi, K. M., Klunder, A. D., Lu, P. H., Edwards, N., … HGDH Study Group, . (2009). Time-lapse mapping of cortical changes in schizophrenia with different treatments. Cereb Cortex, 19(5), 1107–1123. https://doi.org/10.1093/cercor/bhn152
Thompson, Paul M., George Bartzokis, Kiralee M. Hayashi, Andrea D. Klunder, Po H. Lu, Nancy Edwards, Michael S. Hong, et al. “Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cereb Cortex 19, no. 5 (May 2009): 1107–23. https://doi.org/10.1093/cercor/bhn152.
Thompson PM, Bartzokis G, Hayashi KM, Klunder AD, Lu PH, Edwards N, et al. Time-lapse mapping of cortical changes in schizophrenia with different treatments. Cereb Cortex. 2009 May;19(5):1107–23.
Thompson, Paul M., et al. “Time-lapse mapping of cortical changes in schizophrenia with different treatments.Cereb Cortex, vol. 19, no. 5, May 2009, pp. 1107–23. Pubmed, doi:10.1093/cercor/bhn152.
Thompson PM, Bartzokis G, Hayashi KM, Klunder AD, Lu PH, Edwards N, Hong MS, Yu M, Geaga JA, Toga AW, Charles C, Perkins DO, McEvoy J, Hamer RM, Tohen M, Tollefson GD, Lieberman JA, HGDH Study Group. Time-lapse mapping of cortical changes in schizophrenia with different treatments. Cereb Cortex. 2009 May;19(5):1107–1123.
Journal cover image

Published In

Cereb Cortex

DOI

EISSN

1460-2199

Publication Date

May 2009

Volume

19

Issue

5

Start / End Page

1107 / 1123

Location

United States

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Olanzapine
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Humans
  • Haloperidol
  • Female
  • Experimental Psychology