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Drug delivery to solid tumors by elastin-like polypeptides.

Publication ,  Journal Article
McDaniel, JR; Callahan, DJ; Chilkoti, A
Published in: Advanced drug delivery reviews
December 2010

Thermally responsive elastin-like polypeptides (ELPs) are a promising class of recombinant biopolymers for the delivery of drugs and imaging agents to solid tumors via systemic or local administration. This article reviews four applications of ELPs to drug delivery, with each delivery mechanism designed to best exploit the relationship between the characteristic transition temperature (T(t)) of the ELP and body temperature (T(b)). First, when T(t)≫T(b), small hydrophobic drugs can be conjugated to the C-terminus of the ELP to impart the amphiphilicity needed to mediate the self-assembly of nanoparticles. These systemically delivered ELP-drug nanoparticles preferentially localize to the tumor site via the EPR effect, resulting in reduced toxicity and enhanced treatment efficacy. The remaining three approaches take direct advantage of the thermal responsiveness of ELPs. In the second strategy, where T(b)

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2010

Volume

62

Issue

15

Start / End Page

1456 / 1467

Related Subject Headings

  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms
  • Humans
  • Elastin
  • Drug Delivery Systems
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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McDaniel, J. R., Callahan, D. J., & Chilkoti, A. (2010). Drug delivery to solid tumors by elastin-like polypeptides. Advanced Drug Delivery Reviews, 62(15), 1456–1467. https://doi.org/10.1016/j.addr.2010.05.004
McDaniel, Jonathan R., Daniel J. Callahan, and Ashutosh Chilkoti. “Drug delivery to solid tumors by elastin-like polypeptides.Advanced Drug Delivery Reviews 62, no. 15 (December 2010): 1456–67. https://doi.org/10.1016/j.addr.2010.05.004.
McDaniel JR, Callahan DJ, Chilkoti A. Drug delivery to solid tumors by elastin-like polypeptides. Advanced drug delivery reviews. 2010 Dec;62(15):1456–67.
McDaniel, Jonathan R., et al. “Drug delivery to solid tumors by elastin-like polypeptides.Advanced Drug Delivery Reviews, vol. 62, no. 15, Dec. 2010, pp. 1456–67. Epmc, doi:10.1016/j.addr.2010.05.004.
McDaniel JR, Callahan DJ, Chilkoti A. Drug delivery to solid tumors by elastin-like polypeptides. Advanced drug delivery reviews. 2010 Dec;62(15):1456–1467.
Journal cover image

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

December 2010

Volume

62

Issue

15

Start / End Page

1456 / 1467

Related Subject Headings

  • Pharmacology & Pharmacy
  • Peptides
  • Neoplasms
  • Humans
  • Elastin
  • Drug Delivery Systems
  • Antineoplastic Agents
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences