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Elastin-like polypeptides: biomedical applications of tunable biopolymers.

Publication ,  Journal Article
MacEwan, SR; Chilkoti, A
Published in: Biopolymers
January 2010

Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of toxicity, and biocompatibility are attractive features of these biopolymers for biological applications. Elastin-like polypeptides (ELPs) are one such class of biopolymers that are of particular interest because of their "smart"-stimuli responsive-properties. Herein, we discuss the genetically encoded design and recombinant synthesis of ELPs that enable precise control of their physicochemical properties and which have led to a wide range of biomedical applications of these biopolymers in the last decade.

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Published In

Biopolymers

DOI

EISSN

1097-0282

ISSN

0006-3525

Publication Date

January 2010

Volume

94

Issue

1

Start / End Page

60 / 77

Related Subject Headings

  • Tissue Engineering
  • Recombinant Fusion Proteins
  • Protein Conformation
  • Peptides
  • Molecular Structure
  • Hydrogels
  • Elastin
  • Drug Carriers
  • Cross-Linking Reagents
  • Biopolymers
 

Citation

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MacEwan, S. R., & Chilkoti, A. (2010). Elastin-like polypeptides: biomedical applications of tunable biopolymers. Biopolymers, 94(1), 60–77. https://doi.org/10.1002/bip.21327
MacEwan, Sarah R., and Ashutosh Chilkoti. “Elastin-like polypeptides: biomedical applications of tunable biopolymers.Biopolymers 94, no. 1 (January 2010): 60–77. https://doi.org/10.1002/bip.21327.
MacEwan SR, Chilkoti A. Elastin-like polypeptides: biomedical applications of tunable biopolymers. Biopolymers. 2010 Jan;94(1):60–77.
MacEwan, Sarah R., and Ashutosh Chilkoti. “Elastin-like polypeptides: biomedical applications of tunable biopolymers.Biopolymers, vol. 94, no. 1, Jan. 2010, pp. 60–77. Epmc, doi:10.1002/bip.21327.
MacEwan SR, Chilkoti A. Elastin-like polypeptides: biomedical applications of tunable biopolymers. Biopolymers. 2010 Jan;94(1):60–77.
Journal cover image

Published In

Biopolymers

DOI

EISSN

1097-0282

ISSN

0006-3525

Publication Date

January 2010

Volume

94

Issue

1

Start / End Page

60 / 77

Related Subject Headings

  • Tissue Engineering
  • Recombinant Fusion Proteins
  • Protein Conformation
  • Peptides
  • Molecular Structure
  • Hydrogels
  • Elastin
  • Drug Carriers
  • Cross-Linking Reagents
  • Biopolymers