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Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins.

Publication ,  Journal Article
Hoffman, AS; Stayton, PS; Bulmus, V; Chen, G; Chen, J; Cheung, C; Chilkoti, A; Ding, Z; Dong, L; Fong, R; Lackey, CA; Long, CJ; Miura, M ...
Published in: Journal of biomedical materials research
December 2000

Over the past 18 years we have been deeply involved with the synthesis and applications of stimuli-responsive polymer systems, especially polymer-biomolecule conjugates. This article summarizes our work with one of these conjugate systems, specifically polymer-protein conjugates. We include conjugates prepared by random polymer conjugation to lysine amino groups, and also those prepared by site-specific conjugation of the polymer to specific amino acid sites that are genetically engineered into the known amino acid sequence of the protein. We describe the preparation and properties of thermally sensitive random conjugates to enzymes and several affinity recognition proteins. We have also prepared site-specific conjugates to streptavidin with temperature-sensitive polymers, pH-sensitive polymers, and light-sensitive polymers. The preparation of these conjugates and their many fascinating applications are reviewed in this article.

Duke Scholars

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Published In

Journal of biomedical materials research

DOI

EISSN

1097-4636

ISSN

0021-9304

Publication Date

December 2000

Volume

52

Issue

4

Start / End Page

577 / 586

Related Subject Headings

  • Temperature
  • Streptavidin
  • Solubility
  • Societies, Scientific
  • Protein Engineering
  • Mutagenesis, Site-Directed
  • Molecular Structure
  • Materials Testing
  • Light
  • Immunoassay
 

Citation

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Hoffman, A. S., Stayton, P. S., Bulmus, V., Chen, G., Chen, J., Cheung, C., … Miyata, T. (2000). Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. Journal of Biomedical Materials Research, 52(4), 577–586. https://doi.org/10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.0.co;2-5
Hoffman, A. S., P. S. Stayton, V. Bulmus, G. Chen, J. Chen, C. Cheung, A. Chilkoti, et al. “Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins.Journal of Biomedical Materials Research 52, no. 4 (December 2000): 577–86. https://doi.org/10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.0.co;2-5.
Hoffman AS, Stayton PS, Bulmus V, Chen G, Chen J, Cheung C, et al. Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. Journal of biomedical materials research. 2000 Dec;52(4):577–86.
Hoffman, A. S., et al. “Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins.Journal of Biomedical Materials Research, vol. 52, no. 4, Dec. 2000, pp. 577–86. Epmc, doi:10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.0.co;2-5.
Hoffman AS, Stayton PS, Bulmus V, Chen G, Chen J, Cheung C, Chilkoti A, Ding Z, Dong L, Fong R, Lackey CA, Long CJ, Miura M, Morris JE, Murthy N, Nabeshima Y, Park TG, Press OW, Shimoboji T, Shoemaker S, Yang HJ, Monji N, Nowinski RC, Cole CA, Priest JH, Harris JM, Nakamae K, Nishino T, Miyata T. Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins. Journal of biomedical materials research. 2000 Dec;52(4):577–586.

Published In

Journal of biomedical materials research

DOI

EISSN

1097-4636

ISSN

0021-9304

Publication Date

December 2000

Volume

52

Issue

4

Start / End Page

577 / 586

Related Subject Headings

  • Temperature
  • Streptavidin
  • Solubility
  • Societies, Scientific
  • Protein Engineering
  • Mutagenesis, Site-Directed
  • Molecular Structure
  • Materials Testing
  • Light
  • Immunoassay