Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
Publication
, Journal Article
Lim, K-H; Brady, DC; Kashatus, DF; Ancrile, BB; Der, CJ; Cox, AD; Counter, CM
Published in: Mol Cell Biol
January 2010
The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
Duke Scholars
Published In
Mol Cell Biol
DOI
EISSN
1098-5549
Publication Date
January 2010
Volume
30
Issue
2
Start / End Page
508 / 523
Location
United States
Related Subject Headings
- ras Proteins
- ral GTP-Binding Proteins
- Xenograft Model Antitumor Assays
- Protein Serine-Threonine Kinases
- Mutation
- Mice, SCID
- Mice
- Humans
- GTPase-Activating Proteins
- Developmental Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Lim, K.-H., Brady, D. C., Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D., & Counter, C. M. (2010). Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol, 30(2), 508–523. https://doi.org/10.1128/MCB.00916-08
Lim, Kian-Huat, Donita C. Brady, David F. Kashatus, Brooke B. Ancrile, Channing J. Der, Adrienne D. Cox, and Christopher M. Counter. “Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.” Mol Cell Biol 30, no. 2 (January 2010): 508–23. https://doi.org/10.1128/MCB.00916-08.
Lim K-H, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, et al. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol. 2010 Jan;30(2):508–23.
Lim, Kian-Huat, et al. “Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.” Mol Cell Biol, vol. 30, no. 2, Jan. 2010, pp. 508–23. Pubmed, doi:10.1128/MCB.00916-08.
Lim K-H, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol Cell Biol. 2010 Jan;30(2):508–523.
Published In
Mol Cell Biol
DOI
EISSN
1098-5549
Publication Date
January 2010
Volume
30
Issue
2
Start / End Page
508 / 523
Location
United States
Related Subject Headings
- ras Proteins
- ral GTP-Binding Proteins
- Xenograft Model Antitumor Assays
- Protein Serine-Threonine Kinases
- Mutation
- Mice, SCID
- Mice
- Humans
- GTPase-Activating Proteins
- Developmental Biology