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Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China.

Publication ,  Journal Article
Liu, J; Chen, X; Xie, Q; Zhang, W; Wei, L; Shen, T; Xu, Q; Zhuang, H; Gao, F; Lu, F
Published in: AIDS Res Hum Retroviruses
August 2011

Unhygienic blood collection caused an outbreak of HIV-1 and HCV infections among blood donors in rural areas in Henan province, China. Partial HIV-1 pol and HCV NS5b gene sequences were obtained from 97 persons infected with HIV-1 to determine the efficacy of treatment, the prevalence of drug-resistant mutations, and the impact of HCV infection on disease progression of infection with HIV-1. After antiretroviral therapy, 60 out of 97 HIV-1-infected blood donors had their HIV-1 RNA levels reduced to an undetectable level. Drug-resistant mutations to reverse transcriptase inhibitors were detected in one-third of treatment failure patients, with K103N as the most frequent mutation. Drug-resistant mutations were not detected in the other two-thirds of treatment-failure patients, suggesting a poor adherence to the treatment. The majority of HIV-1-infected patients (91.8%) were also infected with HCV. Sequence analysis showed that they were infected with HCV subtype 1b (47.5%) or 2a (52.5%). HCV viral loads were significantly higher in patients infected with subtype 2a than in patients infected with HCV subtype 1b, although no differences in HIV-1 viral loads and CD4(+)T cell counts was observed between the two subtypes. These results suggest that improved adherence and treatment regimens will be critical to effectively treat HIV-1 and HCV-coinfected patients in resource-limited areas.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

August 2011

Volume

27

Issue

8

Start / End Page

925 / 930

Location

United States

Related Subject Headings

  • Virology
  • Viral Load
  • Treatment Outcome
  • Reverse Transcriptase Inhibitors
  • RNA-Directed DNA Polymerase
  • Prevalence
  • Phylogeny
  • Patient Compliance
  • Mutation
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Liu, J., Chen, X., Xie, Q., Zhang, W., Wei, L., Shen, T., … Lu, F. (2011). Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China. AIDS Res Hum Retroviruses, 27(8), 925–930. https://doi.org/10.1089/aid.2010.0328
Liu, Jia, Xiangmei Chen, Qing Xie, Weidong Zhang, Lai Wei, Tao Shen, Qiang Xu, Hui Zhuang, Feng Gao, and Fengmin Lu. “Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China.AIDS Res Hum Retroviruses 27, no. 8 (August 2011): 925–30. https://doi.org/10.1089/aid.2010.0328.
Liu J, Chen X, Xie Q, Zhang W, Wei L, Shen T, et al. Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China. AIDS Res Hum Retroviruses. 2011 Aug;27(8):925–30.
Liu, Jia, et al. “Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China.AIDS Res Hum Retroviruses, vol. 27, no. 8, Aug. 2011, pp. 925–30. Pubmed, doi:10.1089/aid.2010.0328.
Liu J, Chen X, Xie Q, Zhang W, Wei L, Shen T, Xu Q, Zhuang H, Gao F, Lu F. Drug resistance and HCV coinfection in former blood donors infected with HIV type 1 in China. AIDS Res Hum Retroviruses. 2011 Aug;27(8):925–930.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

August 2011

Volume

27

Issue

8

Start / End Page

925 / 930

Location

United States

Related Subject Headings

  • Virology
  • Viral Load
  • Treatment Outcome
  • Reverse Transcriptase Inhibitors
  • RNA-Directed DNA Polymerase
  • Prevalence
  • Phylogeny
  • Patient Compliance
  • Mutation
  • Middle Aged