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In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars.

Publication ,  Journal Article
Yuan, H; Khoury, CG; Wilson, CM; Grant, GA; Bennett, AJ; Vo-Dinh, T
Published in: Nanomedicine
November 2012

UNLABELLED: Gold nanostars offer unique plasmon properties that efficiently transduce photon energy into heat for photothermal therapy. Nanostars, with their small core size and multiple long thin branches, exhibit high absorption cross-sections that are tunable in the near-infrared region with relatively low scattering effect, making them efficient photothermal transducers. Here, we demonstrate particle tracking and photothermal ablation both in vitro and in vivo. Using SKBR3 breast cancer cells incubated with bare nanostars, we observed photothermal ablation within 5 minutes of irradiation (980-nm continuous-wave laser, 15 W/cm2). On a mouse injected systemically with PEGylated nanostars for 2 days, extravasation of nanostars was observed and localized photothermal ablation was demonstrated on a dorsal window chamber within 10 minutes of irradiation (785-nm continuous-wave laser, 1.1 W/cm2). These preliminary results of plasmon-enhanced localized hyperthermia are encouraging and have illustrated the potential of gold nanostars as efficient photothermal agents in cancer therapy. FROM THE CLINICAL EDITOR: Gold nanostars are tunable in the near-infrared region with low scattering, thus enable photothermal therapy. Encouraging preliminary results of plasmon-enhanced localized hyperthermia both in vitro and in vivo demonstrate that Au nanostars may be efficient photothermal agents for cancer therapy.

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Published In

Nanomedicine

DOI

EISSN

1549-9642

Publication Date

November 2012

Volume

8

Issue

8

Start / End Page

1355 / 1363

Location

United States

Related Subject Headings

  • Surface Plasmon Resonance
  • Phototherapy
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Gold
  • Female
  • Cell Line, Tumor
 

Citation

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Chicago
ICMJE
MLA
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Yuan, H., Khoury, C. G., Wilson, C. M., Grant, G. A., Bennett, A. J., & Vo-Dinh, T. (2012). In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars. Nanomedicine, 8(8), 1355–1363. https://doi.org/10.1016/j.nano.2012.02.005
Yuan, Hsiangkuo, Christopher G. Khoury, Christy M. Wilson, Gerald A. Grant, Adam J. Bennett, and Tuan Vo-Dinh. “In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars.Nanomedicine 8, no. 8 (November 2012): 1355–63. https://doi.org/10.1016/j.nano.2012.02.005.
Yuan H, Khoury CG, Wilson CM, Grant GA, Bennett AJ, Vo-Dinh T. In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars. Nanomedicine. 2012 Nov;8(8):1355–63.
Yuan, Hsiangkuo, et al. “In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars.Nanomedicine, vol. 8, no. 8, Nov. 2012, pp. 1355–63. Pubmed, doi:10.1016/j.nano.2012.02.005.
Yuan H, Khoury CG, Wilson CM, Grant GA, Bennett AJ, Vo-Dinh T. In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars. Nanomedicine. 2012 Nov;8(8):1355–1363.
Journal cover image

Published In

Nanomedicine

DOI

EISSN

1549-9642

Publication Date

November 2012

Volume

8

Issue

8

Start / End Page

1355 / 1363

Location

United States

Related Subject Headings

  • Surface Plasmon Resonance
  • Phototherapy
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mice
  • Hyperthermia, Induced
  • Humans
  • Gold
  • Female
  • Cell Line, Tumor