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Antidromic action potential propagation in branched axons

Publication ,  Journal Article
Grill, WM; Robertson, MW
Published in: 2nd International IEEE EMBS Conference on Neural Engineering
December 1, 2005

Electrical stimulation in the central nervous system can generate both orthodromic activity, by stimulation of local cells and passing axons, as well as antidromic activity, by stimulation of presynaptic axons and terminals. We used computational models to study antidromic action potential propagation in branched axons. Antidromic propagation occurred robustly, and action potentials traveled both antidromically into the primary segment as well as "orthodromically" into the terminal secondary segment. Thus, antidromic activation of axon terminals can, through axon collaterals, lead to widespread activation or inhibition of targets distant from the site of stimulation. © 2005 IEEE.

Duke Scholars

Published In

2nd International IEEE EMBS Conference on Neural Engineering

DOI

Publication Date

December 1, 2005

Volume

2005

Start / End Page

183 / 185
 

Citation

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Grill, W. M., & Robertson, M. W. (2005). Antidromic action potential propagation in branched axons. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, 183–185. https://doi.org/10.1109/CNE.2005.1419585
Grill, W. M., and M. W. Robertson. “Antidromic action potential propagation in branched axons.” 2nd International IEEE EMBS Conference on Neural Engineering 2005 (December 1, 2005): 183–85. https://doi.org/10.1109/CNE.2005.1419585.
Grill WM, Robertson MW. Antidromic action potential propagation in branched axons. 2nd International IEEE EMBS Conference on Neural Engineering. 2005 Dec 1;2005:183–5.
Grill, W. M., and M. W. Robertson. “Antidromic action potential propagation in branched axons.” 2nd International IEEE EMBS Conference on Neural Engineering, vol. 2005, Dec. 2005, pp. 183–85. Scopus, doi:10.1109/CNE.2005.1419585.
Grill WM, Robertson MW. Antidromic action potential propagation in branched axons. 2nd International IEEE EMBS Conference on Neural Engineering. 2005 Dec 1;2005:183–185.

Published In

2nd International IEEE EMBS Conference on Neural Engineering

DOI

Publication Date

December 1, 2005

Volume

2005

Start / End Page

183 / 185