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A urethral afferent mediated excitatory bladder reflex exists in humans.

Publication ,  Journal Article
Gustafson, KJ; Creasey, GH; Grill, WM
Published in: Neuroscience letters
April 2004

An excitatory reflex between urethral flow receptors and the bladder has been established in animals, but attempts to demonstrate this reflex in humans using urethral fluid flow have been inconclusive. Intraurethral electrical stimulation has recently been shown to generate bladder contractions in animals and was applied to study the presence of an excitatory urethra to bladder reflex in humans. The prostatic urethra was stimulated electrically via a catheter-based electrode in five men with complete spinal cord injury. Bladder contractions were generated in four of five individuals, however, only when the bladder volume was sufficiently large. These results demonstrate the presence of a volume dependent excitatory bladder reflex mediated by urethral afferent nerve fibers and the lumbosacral spinal cord.

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Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

April 2004

Volume

360

Issue

1-2

Start / End Page

9 / 12

Related Subject Headings

  • Urinary Catheterization
  • Urinary Bladder
  • Urethra
  • Reflex
  • Muscle, Smooth
  • Muscle Contraction
  • Middle Aged
  • Male
  • Humans
  • Electric Stimulation
 

Citation

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Gustafson, K. J., Creasey, G. H., & Grill, W. M. (2004). A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience Letters, 360(1–2), 9–12. https://doi.org/10.1016/j.neulet.2004.01.001
Gustafson, Kenneth J., Graham H. Creasey, and Warren M. Grill. “A urethral afferent mediated excitatory bladder reflex exists in humans.Neuroscience Letters 360, no. 1–2 (April 2004): 9–12. https://doi.org/10.1016/j.neulet.2004.01.001.
Gustafson KJ, Creasey GH, Grill WM. A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience letters. 2004 Apr;360(1–2):9–12.
Gustafson, Kenneth J., et al. “A urethral afferent mediated excitatory bladder reflex exists in humans.Neuroscience Letters, vol. 360, no. 1–2, Apr. 2004, pp. 9–12. Epmc, doi:10.1016/j.neulet.2004.01.001.
Gustafson KJ, Creasey GH, Grill WM. A urethral afferent mediated excitatory bladder reflex exists in humans. Neuroscience letters. 2004 Apr;360(1–2):9–12.
Journal cover image

Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

April 2004

Volume

360

Issue

1-2

Start / End Page

9 / 12

Related Subject Headings

  • Urinary Catheterization
  • Urinary Bladder
  • Urethra
  • Reflex
  • Muscle, Smooth
  • Muscle Contraction
  • Middle Aged
  • Male
  • Humans
  • Electric Stimulation