Skip to main content

Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens.

Publication ,  Journal Article
Guan, Z; Johnston, NC; Aygun-Sunar, S; Daldal, F; Raetz, CRH; Goldfine, H
Published in: Biochim Biophys Acta
March 2011

A study of the polar lipids of Clostridium novyi NT has revealed the presence of phosphatidylethanolamine (PE) and cardiolipin as major phospholipids with smaller amounts of phosphatidylglycerol (PG), lysyl-PG and alanyl-PG. Other minor phospholipids included phosphatidic acid, CDP-diacylglycerol, phosphatidylserine (PS) and phosphatidylthreonine (PT). PE, PG and amino acyl PG were present in both the diacyl and alk-1'-enyl acyl (plasmalogen) forms and cardiolipin plasmalogens were found to contain one or two alk-1'-enyl chains. In contrast, the precursor lipids phosphatidic acid, CDP-diacylglycerol and PS were present almost exclusively as diacyl phospholipids. These findings are consistent with the hypothesis that plasmalogens are formed from diacylated phospholipids at a late stage of phospholipid formation in Clostridium species. This novel pathway contrasts with the route in animals in which a saturated ether bond is formed at an early stage of plasmalogen biosynthesis and the alk-1-enyl bond is formed by an aerobic mechanism.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

March 2011

Volume

1811

Issue

3

Start / End Page

186 / 193

Location

Netherlands

Related Subject Headings

  • Plasmalogens
  • Clostridium
  • Anaerobiosis
  • 06 Biological Sciences
  • 02 Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guan, Z., Johnston, N. C., Aygun-Sunar, S., Daldal, F., Raetz, C. R. H., & Goldfine, H. (2011). Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochim Biophys Acta, 1811(3), 186–193. https://doi.org/10.1016/j.bbalip.2010.12.010
Guan, Ziqiang, Norah C. Johnston, Semra Aygun-Sunar, Fevzi Daldal, Christian R. H. Raetz, and Howard Goldfine. “Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens.Biochim Biophys Acta 1811, no. 3 (March 2011): 186–93. https://doi.org/10.1016/j.bbalip.2010.12.010.
Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CRH, Goldfine H. Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochim Biophys Acta. 2011 Mar;1811(3):186–93.
Guan, Ziqiang, et al. “Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens.Biochim Biophys Acta, vol. 1811, no. 3, Mar. 2011, pp. 186–93. Pubmed, doi:10.1016/j.bbalip.2010.12.010.
Guan Z, Johnston NC, Aygun-Sunar S, Daldal F, Raetz CRH, Goldfine H. Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochim Biophys Acta. 2011 Mar;1811(3):186–193.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

March 2011

Volume

1811

Issue

3

Start / End Page

186 / 193

Location

Netherlands

Related Subject Headings

  • Plasmalogens
  • Clostridium
  • Anaerobiosis
  • 06 Biological Sciences
  • 02 Physical Sciences