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Growth factors for therapeutic angiogenesis in peripheral arterial disease.

Publication ,  Journal Article
Jones, WS; Annex, BH
Published in: Curr Opin Cardiol
September 2007

PURPOSE OF REVIEW: Peripheral arterial disease is a common disease that has few treatment options. Angiogenesis is defined as the growth of new blood vessels from preexisting vasculature. Therapeutic angiogenesis is an investigational method that uses vascular growth to alleviate disorders of tissue ischemia, such as coronary artery disease and peripheral arterial disease. There have been tremendous changes in the field of therapeutic angiogenesis over the past decade, and there is much promise for the future. RECENT FINDINGS: Initial preclinical work with cytokine growth factor delivery resulted in a great deal of enthusiasm, but larger clinical studies have failed to achieve similar success. With an increased understanding of the complex mechanisms involved in angiogenesis, gene therapy and cell therapy have moved to the forefront of therapeutic angiogenesis. Novel therapies which target multiple different angiogenic pathways are also being developed and tested. SUMMARY: Therapeutic angiogenesis is an exciting field that continues to evolve. This review will focus on the different growth factors being used, their routes of delivery, the results of clinical trials, and some of the novel therapies being developed.

Duke Scholars

Published In

Curr Opin Cardiol

DOI

ISSN

0268-4705

Publication Date

September 2007

Volume

22

Issue

5

Start / End Page

458 / 463

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Recombinant Proteins
  • Peripheral Vascular Diseases
  • Neovascularization, Physiologic
  • Humans
  • Genetic Therapy
  • Fibroblast Growth Factors
  • Drug Administration Routes
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
 

Citation

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Jones, W. S., & Annex, B. H. (2007). Growth factors for therapeutic angiogenesis in peripheral arterial disease. Curr Opin Cardiol, 22(5), 458–463. https://doi.org/10.1097/HCO.0b013e328236741b
Jones, William S., and Brian H. Annex. “Growth factors for therapeutic angiogenesis in peripheral arterial disease.Curr Opin Cardiol 22, no. 5 (September 2007): 458–63. https://doi.org/10.1097/HCO.0b013e328236741b.
Jones WS, Annex BH. Growth factors for therapeutic angiogenesis in peripheral arterial disease. Curr Opin Cardiol. 2007 Sep;22(5):458–63.
Jones, William S., and Brian H. Annex. “Growth factors for therapeutic angiogenesis in peripheral arterial disease.Curr Opin Cardiol, vol. 22, no. 5, Sept. 2007, pp. 458–63. Pubmed, doi:10.1097/HCO.0b013e328236741b.
Jones WS, Annex BH. Growth factors for therapeutic angiogenesis in peripheral arterial disease. Curr Opin Cardiol. 2007 Sep;22(5):458–463.

Published In

Curr Opin Cardiol

DOI

ISSN

0268-4705

Publication Date

September 2007

Volume

22

Issue

5

Start / End Page

458 / 463

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Recombinant Proteins
  • Peripheral Vascular Diseases
  • Neovascularization, Physiologic
  • Humans
  • Genetic Therapy
  • Fibroblast Growth Factors
  • Drug Administration Routes
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology