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Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.

Publication ,  Journal Article
Sansone, SM; Widaman, KF; Hall, SS; Reiss, AL; Lightbody, A; Kaufmann, WE; Berry-Kravis, E; Lachiewicz, A; Brown, EC; Hessl, D
Published in: J Autism Dev Disord
July 2012

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

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Published In

J Autism Dev Disord

DOI

EISSN

1573-3432

Publication Date

July 2012

Volume

42

Issue

7

Start / End Page

1377 / 1392

Location

United States

Related Subject Headings

  • Young Adult
  • Social Adjustment
  • Reproducibility of Results
  • Psychotropic Drugs
  • Psychometrics
  • Personality Assessment
  • Outcome Assessment, Health Care
  • Male
  • Intellectual Disability
  • Humans
 

Citation

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Sansone, S. M., Widaman, K. F., Hall, S. S., Reiss, A. L., Lightbody, A., Kaufmann, W. E., … Hessl, D. (2012). Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment. J Autism Dev Disord, 42(7), 1377–1392. https://doi.org/10.1007/s10803-011-1370-2
Sansone, Stephanie M., Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, and David Hessl. “Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.J Autism Dev Disord 42, no. 7 (July 2012): 1377–92. https://doi.org/10.1007/s10803-011-1370-2.
Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, et al. Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment. J Autism Dev Disord. 2012 Jul;42(7):1377–92.
Sansone, Stephanie M., et al. “Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.J Autism Dev Disord, vol. 42, no. 7, July 2012, pp. 1377–92. Pubmed, doi:10.1007/s10803-011-1370-2.
Sansone SM, Widaman KF, Hall SS, Reiss AL, Lightbody A, Kaufmann WE, Berry-Kravis E, Lachiewicz A, Brown EC, Hessl D. Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment. J Autism Dev Disord. 2012 Jul;42(7):1377–1392.
Journal cover image

Published In

J Autism Dev Disord

DOI

EISSN

1573-3432

Publication Date

July 2012

Volume

42

Issue

7

Start / End Page

1377 / 1392

Location

United States

Related Subject Headings

  • Young Adult
  • Social Adjustment
  • Reproducibility of Results
  • Psychotropic Drugs
  • Psychometrics
  • Personality Assessment
  • Outcome Assessment, Health Care
  • Male
  • Intellectual Disability
  • Humans