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Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis.

Publication ,  Journal Article
Schmajuk, NA; Larrauri, JA; Hagenbuch, N; Levin, ED; Feldon, J; Yee, BK
Published in: Behav Brain Res
June 30, 2006

Schmajuk and Larrauri [Schmajuk NA, Larrauri JA. Neural network model of prepulse inhibition. Behav Neurosci 2005;119:1546-62.] introduced a real-time model of acoustic startle, prepulse inhibition (PPI) and facilitation (PPF) in animals and humans. The model assumes that (1) positive values of changes in noise level activate an excitatory and a facilitatory pathway, and (2) absolute values of changes in noise level activate an inhibitory pathway. The model describes many known properties of the phenomena and the effect of brain lesions on startle, PPI, and PPF. The purpose of the present study is to (a) establish the magnitude of startle and PPI as a function of pulse, prepulse, and background intensity, and (b) test the model predictions regarding an inverted-U function that relates startle to the intensity of the background noise.

Duke Scholars

Published In

Behav Brain Res

DOI

ISSN

0166-4328

Publication Date

June 30, 2006

Volume

170

Issue

2

Start / End Page

182 / 196

Location

Netherlands

Related Subject Headings

  • Reflex, Startle
  • Reflex, Acoustic
  • Rats, Sprague-Dawley
  • Rats
  • Noise
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Models, Biological
  • Mice
  • Male
 

Citation

APA
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ICMJE
MLA
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Schmajuk, N. A., Larrauri, J. A., Hagenbuch, N., Levin, E. D., Feldon, J., & Yee, B. K. (2006). Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. Behav Brain Res, 170(2), 182–196. https://doi.org/10.1016/j.bbr.2006.02.021
Schmajuk, N. A., J. A. Larrauri, N. Hagenbuch, E. D. Levin, J. Feldon, and B. K. Yee. “Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis.Behav Brain Res 170, no. 2 (June 30, 2006): 182–96. https://doi.org/10.1016/j.bbr.2006.02.021.
Schmajuk NA, Larrauri JA, Hagenbuch N, Levin ED, Feldon J, Yee BK. Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. Behav Brain Res. 2006 Jun 30;170(2):182–96.
Schmajuk, N. A., et al. “Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis.Behav Brain Res, vol. 170, no. 2, June 2006, pp. 182–96. Pubmed, doi:10.1016/j.bbr.2006.02.021.
Schmajuk NA, Larrauri JA, Hagenbuch N, Levin ED, Feldon J, Yee BK. Startle and prepulse inhibition as a function of background noise: a computational and experimental analysis. Behav Brain Res. 2006 Jun 30;170(2):182–196.
Journal cover image

Published In

Behav Brain Res

DOI

ISSN

0166-4328

Publication Date

June 30, 2006

Volume

170

Issue

2

Start / End Page

182 / 196

Location

Netherlands

Related Subject Headings

  • Reflex, Startle
  • Reflex, Acoustic
  • Rats, Sprague-Dawley
  • Rats
  • Noise
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Models, Biological
  • Mice
  • Male