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Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.

Publication ,  Journal Article
Lee, WH; Lisanby, SH; Laine, AF; Peterchev, AV
Published in: Annu Int Conf IEEE Eng Med Biol Soc
2012

This study investigates the stimulation strength and focality of electroconvulsive therapy (ECT) with individualized current amplitude in a nonhuman primate (NHP) model. We generated an anatomically realistic finite element model of a NHP head incorporating tissue heterogeneity and white matter conductivity anisotropy based on structural magnetic resonance imaging (MRI) and diffusion tensor MRI data. The electric field spatial distributions of three conventional ECT electrode placements (bilateral, bifrontal, and right unilateral) and an experimental frontomedial electrode configuration were simulated. We calibrated the electric field maps relative to an empirical neural activation threshold and evaluated the stimulation strength and focality of the various ECT electrode configurations with individualized current amplitudes corresponding to the motor threshold and seizure threshold assessed in the anesthetized NHP. Understanding the stimulation strength and focality of various forms of ECT could provide insight into the mechanisms of therapeutic seizure induction, and could provide support for the clinical investigation of ECT with individualized current amplitude as an intervention with potentially improved risk/benefit ratio.

Duke Scholars

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

EISSN

2694-0604

Publication Date

2012

Volume

2012

Start / End Page

6430 / 6433

Location

United States

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Finite Element Analysis
  • Electroconvulsive Therapy
  • Brain
  • Animals
 

Citation

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Lee, W. H., Lisanby, S. H., Laine, A. F., & Peterchev, A. V. (2012). Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study. Annu Int Conf IEEE Eng Med Biol Soc, 2012, 6430–6433. https://doi.org/10.1109/EMBC.2012.6347466
Lee, Won Hee, Sarah H. Lisanby, Andrew F. Laine, and Angel V. Peterchev. “Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.Annu Int Conf IEEE Eng Med Biol Soc 2012 (2012): 6430–33. https://doi.org/10.1109/EMBC.2012.6347466.
Lee WH, Lisanby SH, Laine AF, Peterchev AV. Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6430–3.
Lee, Won Hee, et al. “Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study.Annu Int Conf IEEE Eng Med Biol Soc, vol. 2012, 2012, pp. 6430–33. Pubmed, doi:10.1109/EMBC.2012.6347466.
Lee WH, Lisanby SH, Laine AF, Peterchev AV. Stimulation strength and focality of electroconvulsive therapy with individualized current amplitude: a preclinical study. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6430–6433.

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

EISSN

2694-0604

Publication Date

2012

Volume

2012

Start / End Page

6430 / 6433

Location

United States

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Macaca mulatta
  • Finite Element Analysis
  • Electroconvulsive Therapy
  • Brain
  • Animals