Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors.
Publication
, Journal Article
Savage, DD; Rigsbee, LC; McNamara, JO
Published in: J Neurosci
February 1985
This report examines the effect of transection of the entorhinal hippocampal projection on amygdaloid kindling. We found that: bilateral knife cuts of entorhinal cortex but not of dorsal neocortex antagonize the development of amygdaloid kindling; and bilateral knife cuts of entorhinal cortex eliminate the seizure-induced decrease in number of muscarinic receptors of dentate granule cells. We suggest the following interpretations of these data: the hippocampal formation circuitry facilitates the development of amygdaloid kindling; and the decline of muscarinic receptors after kindled seizures is due to excessive activation of granule cells by axons from entorhinal cortex, a noncholinergic afferent.
Duke Scholars
Published In
J Neurosci
DOI
ISSN
0270-6474
Publication Date
February 1985
Volume
5
Issue
2
Start / End Page
408 / 413
Location
United States
Related Subject Headings
- Tritium
- Seizures
- Receptors, Muscarinic
- Rats, Inbred Strains
- Rats
- Quinuclidinyl Benzilate
- Neurology & Neurosurgery
- Male
- Kindling, Neurologic
- Hippocampus
Citation
APA
Chicago
ICMJE
MLA
NLM
Savage, D. D., Rigsbee, L. C., & McNamara, J. O. (1985). Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors. J Neurosci, 5(2), 408–413. https://doi.org/10.1523/JNEUROSCI.05-02-00408.1985
Savage, D. D., L. C. Rigsbee, and J. O. McNamara. “Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors.” J Neurosci 5, no. 2 (February 1985): 408–13. https://doi.org/10.1523/JNEUROSCI.05-02-00408.1985.
Savage DD, Rigsbee LC, McNamara JO. Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors. J Neurosci. 1985 Feb;5(2):408–13.
Savage, D. D., et al. “Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors.” J Neurosci, vol. 5, no. 2, Feb. 1985, pp. 408–13. Pubmed, doi:10.1523/JNEUROSCI.05-02-00408.1985.
Savage DD, Rigsbee LC, McNamara JO. Knife cuts of entorhinal cortex: effects on development of amygdaloid kindling and seizure-induced decrease of muscarinic cholinergic receptors. J Neurosci. 1985 Feb;5(2):408–413.
Published In
J Neurosci
DOI
ISSN
0270-6474
Publication Date
February 1985
Volume
5
Issue
2
Start / End Page
408 / 413
Location
United States
Related Subject Headings
- Tritium
- Seizures
- Receptors, Muscarinic
- Rats, Inbred Strains
- Rats
- Quinuclidinyl Benzilate
- Neurology & Neurosurgery
- Male
- Kindling, Neurologic
- Hippocampus