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Modelling the periodicity of cardiac muscle.

Publication ,  Journal Article
Krassowska, W; Pilkington, TC; Ideker, RE
Published in: Journal of electrocardiology
January 1989

The intractable problem of modelling cardiac muscle of arbitrary extent while preserving cellular structure has been solved using an analytical rather than numerical approach with a method called two-scale asymptotic analysis. In this method, the myocardium was modelled as a collection of bundles arranged periodically in space and connected by junctions, and the distribution of the steady-state potential and current density was determined. The potential both along and across fibers was found to contain a distinct periodic component that determines the transmembrane potential. The magnitude of the transmembrane potential depends on the gradient of applied potential, the dimensions of the bundles, and their internal conductivity. Current flows primarily in the extracellular space, and the extracellular pathway also determines the apparent conductivity of cardiac muscle.

Duke Scholars

Published In

Journal of electrocardiology

DOI

EISSN

1532-8430

ISSN

0022-0736

Publication Date

January 1989

Volume

22 Suppl

Start / End Page

41 / 47

Related Subject Headings

  • Periodicity
  • Myocardium
  • Models, Structural
  • Models, Cardiovascular
  • Membrane Potentials
  • Humans
  • Heart
  • Extracellular Space
  • Electrophysiology
  • Electric Conductivity
 

Citation

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ICMJE
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Krassowska, W., Pilkington, T. C., & Ideker, R. E. (1989). Modelling the periodicity of cardiac muscle. Journal of Electrocardiology, 22 Suppl, 41–47. https://doi.org/10.1016/s0022-0736(07)80099-9
Krassowska, W., T. C. Pilkington, and R. E. Ideker. “Modelling the periodicity of cardiac muscle.Journal of Electrocardiology 22 Suppl (January 1989): 41–47. https://doi.org/10.1016/s0022-0736(07)80099-9.
Krassowska W, Pilkington TC, Ideker RE. Modelling the periodicity of cardiac muscle. Journal of electrocardiology. 1989 Jan;22 Suppl:41–7.
Krassowska, W., et al. “Modelling the periodicity of cardiac muscle.Journal of Electrocardiology, vol. 22 Suppl, Jan. 1989, pp. 41–47. Epmc, doi:10.1016/s0022-0736(07)80099-9.
Krassowska W, Pilkington TC, Ideker RE. Modelling the periodicity of cardiac muscle. Journal of electrocardiology. 1989 Jan;22 Suppl:41–47.
Journal cover image

Published In

Journal of electrocardiology

DOI

EISSN

1532-8430

ISSN

0022-0736

Publication Date

January 1989

Volume

22 Suppl

Start / End Page

41 / 47

Related Subject Headings

  • Periodicity
  • Myocardium
  • Models, Structural
  • Models, Cardiovascular
  • Membrane Potentials
  • Humans
  • Heart
  • Extracellular Space
  • Electrophysiology
  • Electric Conductivity