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Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.

Publication ,  Journal Article
Meyerhardt, JA; Heseltine, D; Niedzwiecki, D; Hollis, D; Saltz, LB; Mayer, RJ; Thomas, J; Nelson, H; Whittom, R; Hantel, A; Schilsky, RL; Fuchs, CS
Published in: J Clin Oncol
August 1, 2006

PURPOSE: Regular physical activity reduces the risk of developing colon cancer, however, its influence on patients with established disease is unknown. PATIENTS AND METHODS: We conducted a prospective observational study of 832 patients with stage III colon cancer enrolled in a randomized adjuvant chemotherapy trial. Patients reported on various recreational physical activities approximately 6 months after completion of therapy and were observed for recurrence or death. To minimize bias by occult recurrence, we excluded patients who experienced recurrence or died within 90 days of their physical activity assessment. RESULTS: Compared with patients engaged in less than three metabolic equivalent task (MET) -hours per week of physical activity, the adjusted hazard ratio for disease-free survival was 0.51 (95% CI, 0.26 to 0.97) for 18 to 26.9 MET-hours per week and 0.55 (95% CI, 0.33 to 0.91) for 27 or more MET-hours per week. The adjusted P for trend was .01. Postdiagnosis activity was associated with similar improvements in recurrence-free survival (P for trend = .03) and overall survival (P for trend = .01). The benefit associated with physical activity was not significantly modified by sex, body mass index, number of positive lymph nodes, age, baseline performance status, or chemotherapy received. Moreover, the benefit remained unchanged even after excluding participants who developed cancer recurrence or died within 6 months of activity assessment. CONCLUSION: Beyond surgical resection and postoperative adjuvant chemotherapy for stage III colon cancer, for patients who survive and are recurrence free approximately 6 months after adjuvant chemotherapy, physical activity appears to reduce the risk of cancer recurrence and mortality.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 1, 2006

Volume

24

Issue

22

Start / End Page

3535 / 3541

Location

United States

Related Subject Headings

  • Survival Analysis
  • Recreation
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Physical Exertion
  • Oncology & Carcinogenesis
  • Observation
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Motor Activity
 

Citation

APA
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ICMJE
MLA
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Meyerhardt, J. A., Heseltine, D., Niedzwiecki, D., Hollis, D., Saltz, L. B., Mayer, R. J., … Fuchs, C. S. (2006). Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol, 24(22), 3535–3541. https://doi.org/10.1200/JCO.2006.06.0863
Meyerhardt, Jeffrey A., Denise Heseltine, Donna Niedzwiecki, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, James Thomas, et al. “Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.J Clin Oncol 24, no. 22 (August 1, 2006): 3535–41. https://doi.org/10.1200/JCO.2006.06.0863.
Meyerhardt JA, Heseltine D, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006 Aug 1;24(22):3535–41.
Meyerhardt, Jeffrey A., et al. “Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803.J Clin Oncol, vol. 24, no. 22, Aug. 2006, pp. 3535–41. Pubmed, doi:10.1200/JCO.2006.06.0863.
Meyerhardt JA, Heseltine D, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Thomas J, Nelson H, Whittom R, Hantel A, Schilsky RL, Fuchs CS. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006 Aug 1;24(22):3535–3541.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

August 1, 2006

Volume

24

Issue

22

Start / End Page

3535 / 3541

Location

United States

Related Subject Headings

  • Survival Analysis
  • Recreation
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Physical Exertion
  • Oncology & Carcinogenesis
  • Observation
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Motor Activity