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Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration

Publication ,  Journal Article
Tward, DJ; Ceritoglu, C; Sturgeon, G; Segars, WP; Miller, MI; Ratnanather, JT
Published in: 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
June 16, 2011

This work describes a protocol for creating a population of pediatric, patient specific, computational dosimetry phantoms. Pediatric CT data are mapped to a detailed adult template using multi channel (MC) - large deformation diffeomorphic metric mapping (LDDMM) applied to whole body images. Challenges are studied and overcome using 2D LDDMM applied to simulated phantoms. The protocol involves automatic placement of landmarks, landmark based affine and LDDMM registration, followed by 4 applications of MC-LDDMM, with successively decreasing smoothness constraints. Deformed adult organ surfaces typically agree with pediatric organ surfaces within 1-2 voxels (∼2.3 mm). © 2011 IEEE.

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2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011

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Publication Date

June 16, 2011
 

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Tward, D. J., Ceritoglu, C., Sturgeon, G., Segars, W. P., Miller, M. I., & Ratnanather, J. T. (2011). Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration. 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011. https://doi.org/10.1109/NEBC.2011.5778717
Tward, D. J., C. Ceritoglu, G. Sturgeon, W. P. Segars, M. I. Miller, and J. T. Ratnanather. “Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration.” 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011, June 16, 2011. https://doi.org/10.1109/NEBC.2011.5778717.
Tward DJ, Ceritoglu C, Sturgeon G, Segars WP, Miller MI, Ratnanather JT. Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration. 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011. 2011 Jun 16;
Tward, D. J., et al. “Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration.” 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011, June 2011. Scopus, doi:10.1109/NEBC.2011.5778717.
Tward DJ, Ceritoglu C, Sturgeon G, Segars WP, Miller MI, Ratnanather JT. Generating patient-specific dosimetry phantoms with whole-body diffeomorphic image registration. 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011. 2011 Jun 16;

Published In

2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011

DOI

Publication Date

June 16, 2011