Skip to main content

Simulation of left ventricular dyssynchrony using the XCAT phantom

Publication ,  Journal Article
Cheung, AA; Niu, T; Faber, TL; Segars, WP; Zhu, L; Chen, J
Published in: IEEE Nuclear Science Symposium Conference Record
December 1, 2010

Multi-Harmonic Phase Analysis (MHPA) has been developed to quantify left-ventricular (LV) mechanical dyssynchrony with gated single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). Although MHPA has shown promising clinical results, it needs to be optimized technically. The purpose of this study is to develop a tool to simulate LV mechanical dyssynchrony in gated SPECT MPI using an extended cardiac torso phantom (XCAT). A special version of the XCAT phantom was developed to control regional myocardial wall thickening using more than 300 B-splines points over the LV myocardium and 26 temporal frames over a cardiac cycle. By shifting the regional myocardial wall thickness values in the temporal domain, regional phase delays can be simulated to represent LV mechanical dyssynchrony. Gated SPECT data were created with phase delays of 0°, ±20°, ±40°, and ±60° in the anterior wall for a LV with normal perfusion. The activity maps given by XCAT were submitted to a SPECT simulator to generate gated SPECT projections. The gated SPECT projections were reconstructed and reoriented into gated short-axis images, which were then submitted to MHPA. A correlation of R2 0.9941 between MHPA measured and simulated regional phase delays was obtained, indicating that MHPA can accurately measure the simulated phase delays. Thus, a simulation tool based on the XCAT phantom has been developed to simulate regional phase delays, which can be accurately measured by MHPA. This tool can offer the opportunities to investigate the relationship between phase delay and myocardial defect, and to optimize MHPA for various factors such as noise and cardiac torsion in future studies. © 2010 IEEE.

Duke Scholars

Published In

IEEE Nuclear Science Symposium Conference Record

DOI

ISSN

1095-7863

Publication Date

December 1, 2010

Start / End Page

3187 / 3189
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cheung, A. A., Niu, T., Faber, T. L., Segars, W. P., Zhu, L., & Chen, J. (2010). Simulation of left ventricular dyssynchrony using the XCAT phantom. IEEE Nuclear Science Symposium Conference Record, 3187–3189. https://doi.org/10.1109/NSSMIC.2010.5874391
Cheung, A. A., T. Niu, T. L. Faber, W. P. Segars, L. Zhu, and J. Chen. “Simulation of left ventricular dyssynchrony using the XCAT phantom.” IEEE Nuclear Science Symposium Conference Record, December 1, 2010, 3187–89. https://doi.org/10.1109/NSSMIC.2010.5874391.
Cheung AA, Niu T, Faber TL, Segars WP, Zhu L, Chen J. Simulation of left ventricular dyssynchrony using the XCAT phantom. IEEE Nuclear Science Symposium Conference Record. 2010 Dec 1;3187–9.
Cheung, A. A., et al. “Simulation of left ventricular dyssynchrony using the XCAT phantom.” IEEE Nuclear Science Symposium Conference Record, Dec. 2010, pp. 3187–89. Scopus, doi:10.1109/NSSMIC.2010.5874391.
Cheung AA, Niu T, Faber TL, Segars WP, Zhu L, Chen J. Simulation of left ventricular dyssynchrony using the XCAT phantom. IEEE Nuclear Science Symposium Conference Record. 2010 Dec 1;3187–3189.

Published In

IEEE Nuclear Science Symposium Conference Record

DOI

ISSN

1095-7863

Publication Date

December 1, 2010

Start / End Page

3187 / 3189