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Ion channels in analgesia research.

Publication ,  Journal Article
Rosenbaum, T; Simon, SA; Islas, LD
Published in: Methods Mol Biol
2010

Several recent techniques have allowed us to pinpoint the receptors responsible for the detection of nociceptive stimuli. Among these receptors, ion channels play a fundamental role in the recognition and transduction of stimuli that can cause pain. During the last decade, compelling evidence has been gathered on the role of the TRPV1 channel in inflammatory and neuropathic states. Activation of TRPV1 in nociceptive neurons results in the release of neuropeptides and transmitters, leading to the generation of action potentials that will be sent to higher CNS areas, where they will often be perceived as pain. Its activation will also evoke the peripheral release of pro-inflammatory compounds that may sensitize other neurons to physical, thermal, or chemical stimuli. For these reasons, and because its continuous activation causes analgesia, TRPV1 is now considered a viable drug target for clinical use in the management of pain. Using the TRPV1 channel as an example, here we describe some basic biophysical approaches used to study the properties of ion channels involved in pain and in analgesia.

Duke Scholars

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2010

Volume

617

Start / End Page

223 / 236

Location

United States

Related Subject Headings

  • TRPV Cation Channels
  • Sensory System Agents
  • Protein Isoforms
  • Patch-Clamp Techniques
  • Pain
  • Nociceptors
  • Ion Channels
  • Humans
  • Developmental Biology
  • Cell Line
 

Citation

APA
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ICMJE
MLA
NLM
Rosenbaum, T., Simon, S. A., & Islas, L. D. (2010). Ion channels in analgesia research. Methods Mol Biol, 617, 223–236. https://doi.org/10.1007/978-1-60327-323-7_18
Rosenbaum, Tamara, Sidney A. Simon, and Leon D. Islas. “Ion channels in analgesia research.Methods Mol Biol 617 (2010): 223–36. https://doi.org/10.1007/978-1-60327-323-7_18.
Rosenbaum T, Simon SA, Islas LD. Ion channels in analgesia research. Methods Mol Biol. 2010;617:223–36.
Rosenbaum, Tamara, et al. “Ion channels in analgesia research.Methods Mol Biol, vol. 617, 2010, pp. 223–36. Pubmed, doi:10.1007/978-1-60327-323-7_18.
Rosenbaum T, Simon SA, Islas LD. Ion channels in analgesia research. Methods Mol Biol. 2010;617:223–236.

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2010

Volume

617

Start / End Page

223 / 236

Location

United States

Related Subject Headings

  • TRPV Cation Channels
  • Sensory System Agents
  • Protein Isoforms
  • Patch-Clamp Techniques
  • Pain
  • Nociceptors
  • Ion Channels
  • Humans
  • Developmental Biology
  • Cell Line