Real-time theoretical compartmental model of blood-brain barrier drug delivery.
Publication
, Conference
Pourtaheri, N; Truskey, GA
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
January 2004
This study developed upon the Mahar Doan and Boje simulations to create a novel pharmacokinetic/pharmacodynamic real-time compartmental model in Simulink. The model allowed for varying combinations of oral and intravenous drug dosing under steady and nonsteady-state endogenous transport inhibition methods. A joint pharmacodynamic model simulated an extracellular receptor binding process and an intracellular enzymatic process as drug effect sites. Initial simulations were compared with the Mahar Doan and Boje data. Further simulation demonstrated the freedom and broadened understanding of drug kinetics and dynamics the implemented real-time model provided.
Duke Scholars
Published In
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
DOI
ISSN
1557-170X
Publication Date
January 2004
Volume
2006
Start / End Page
790 / 796
Citation
APA
Chicago
ICMJE
MLA
NLM
Pourtaheri, N., & Truskey, G. A. (2004). Real-time theoretical compartmental model of blood-brain barrier drug delivery. In Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference (Vol. 2006, pp. 790–796). https://doi.org/10.1109/iembs.2004.1403277
Pourtaheri, Navid, and George A. Truskey. “Real-time theoretical compartmental model of blood-brain barrier drug delivery.” In Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006:790–96, 2004. https://doi.org/10.1109/iembs.2004.1403277.
Pourtaheri N, Truskey GA. Real-time theoretical compartmental model of blood-brain barrier drug delivery. In: Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2004. p. 790–6.
Pourtaheri, Navid, and George A. Truskey. “Real-time theoretical compartmental model of blood-brain barrier drug delivery.” Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2006, 2004, pp. 790–96. Epmc, doi:10.1109/iembs.2004.1403277.
Pourtaheri N, Truskey GA. Real-time theoretical compartmental model of blood-brain barrier drug delivery. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2004. p. 790–796.
Published In
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
DOI
ISSN
1557-170X
Publication Date
January 2004
Volume
2006
Start / End Page
790 / 796