Overview
My research interests focus upon the effect of physical forces on the function of vascular cells and skeletal muscle, cell adhesion, and the design of engineered tissues. Current research projects examine the effect of endothelial cell senescence upon permeability to macromolecules and the response to fluid shear stress, the development of microphysiological blood vessels and muscles for evaluation of drug toxicity and the design of engineered endothelialized blood vessels and skeletal muscle bundles.
Current Appointments & Affiliations
R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
·
2011 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor of Biomedical Engineering
·
2000 - Present
Biomedical Engineering,
Pratt School of Engineering
Affiliate of the Duke Initiative for Science & Society
·
2014 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Publications
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease.
Journal Article Nature aging · June 2025 Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well understood. Here we f ... Full text CiteAuthor Correction: Differential response of tissue engineered skeletal muscle from rheumatoid arthritis patients and healthy controls.
Journal Article Commun Biol · May 30, 2025 Full text Link to item CiteDevelopment of small tissue engineered blood vessels and their clinical and research applications.
Journal Article Biofabrication · May 2025 Since the first tissue engineered blood vessel (TEBV) was developed, different approaches, biomaterial scaffolds and cell sources have been used to obtain an engineered vessel as much similar as native vessels in terms of structure, functionality and mecha ... Full text CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Unified Program for Therapeutics in Children
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function
ResearchCo Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2024 - 2029View All Grants
Education, Training & Certifications
Massachusetts Institute of Technology ·
1985
Ph.D.
University of Pennsylvania ·
1979
B.S.E.