https://orcid.org/0000-0002-6885-4489
Overview
My research interests focus upon the effect of physical forces on the function of vascular cells and skeletal muscle, cell adhesion, and the design of engineered tissues. Current research projects examine the effect of endothelial cell senescence upon permeability to macromolecules and the response to fluid shear stress, the development of microphysiological blood vessels and muscles for evaluation of drug toxicity and the design of engineered endothelialized blood vessels and skeletal muscle bundles.
Current Duke Appointments & Affiliations
R. Eugene and Susie E. Goodson Distinguished Professor of Biomedical Engineering
·
2011 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor of Biomedical Engineering
·
2000 - Present
Biomedical Engineering,
Pratt School of Engineering
Affiliate of the Duke Initiative for Science & Society
·
2014 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Scholarly Works
Design and Rationale of the pERSonalized cardIovascuLar dIsease prEvention, treatmeNt, and CarE (RESILIENCE) study.
Journal article Contemp Clin Trials · August 2026 BACKGROUND: Obesity is a growing epidemic associated with cardiovascular disease (CVD). The RESILIENCE study aimed to understand the factors underlying heterogeneity in CVD development among individuals with obesity as well as the variability in response t ... Full text Link to item CiteRYR1+ skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.
Journal article J Transl Med · May 26, 2026 BACKGROUND: Skeletal muscle is a central regulator of insulin sensitivity and glucose homeostasis. The ryanodine receptor 1 (RYR1) is highly expressed in skeletal muscle and plays a key role in myogenic differentiation. We hypothesize that RYR1+ extracellu ... Full text Link to item CiteMessaging Modality and Content for Recruitment of Research Participants: A Randomized Clinical Trial.
Journal article JAMA Netw Open · May 1, 2026 IMPORTANCE: Optimizing participant recruitment is critical to the success and generalizability of clinical research, yet there is limited randomized clinical trial evidence comparing the effects of digital recruitment strategies and message framing on part ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Unified Program for Therapeutics in Children
Inst. Training Prgm or CMEPreceptor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2025 - 2030Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function
ResearchCo Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2024 - 2029View All Grants
Education
Massachusetts Institute of Technology ·
1985
Ph.D.
University of Pennsylvania ·
1979
B.S.E.