Research Interests
Cardiovascular tissue engineering, mechanisms of atherogenesis, cell adhesion, and cell biomechanics.
Selected Grants
Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function
ResearchCo Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2024 - 2029Translational Center for Barrier Microphysiological Systems
ResearchPrincipal Investigator · Awarded by University of Rochester · 2024 - 2028Stimulating Access to Research in Residency (StARR) - NHLBI
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028Using Bioengineered Human Muscle to Develop Treatments for Juvenile Dermatomyositis
ResearchCollaborator · Awarded by Hartwell Foundation · 2025 - 2028Duke Preparing Research Scholars in Biomedical Sciences- Post-Baccalaureate Research Education Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Staphylococcus aureus Cardiac Device Infections - From the Vascular Viewpoint (K23)
ResearchMentor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027Investigating Endothelial Inflammation and Bacterial Infection in Cardiac Device Implantation
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2025 - 2026Development of an acoustofluidic bioprinter for the fabrication of 3D tissue constructs with single-cell resolution
ResearchCo Investigator · Awarded by Virginia Polytechnic Institute and State University · 2022 - 2026Investigating the Effects of Hutchinson-Gilford Progeria Syndrome Mutation Correction in Tissue-Engineered Blood Vessels
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026Using bioengineered human muscle to understand mechanisms of juvenile dermatomyositis
ResearchMentor · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2025 - 2026Vascular Tissue Engineering for Patients with Peripheral Vascular Disease and Comorbidities
ResearchCo-Mentor · Awarded by American Heart Association · 2025 - 2026Hematology & Transfusion Medicine (T32)
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1975 - 2026Development of a digital acoustofluidic system for automating liquid handling in biomedical research
ResearchCo Investigator · Awarded by National Institute of General Medical Sciences · 2021 - 2026In Vitro Human Tissue-Engineered Blood Vessel Disease Model of Progeria
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2017 - 2026Duke Center for Advancement of Child Health (CAtCH).
Inst. Training Prgm or CMEMentor · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026Integrating engineered blood vessel mimic and muscle to study the relation of Rheumatoid Arthritis and atherosclerosis
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2024 - 2025Perpetual Organ Preservation and Rehabilitation (POPR)
ResearchCollaborator · Awarded by National Institutes of Health · 2022 - 2025An integrated microfluidic system with engineered blood vessel mimic and skeletal muscle to investigate the relation between rheumatoid arthritis and atherosclerosis
FellowshipPrincipal Investigator · Awarded by International Foundation for Ethical Research · 2023 - 2025Cardiac Device Infection in Microphysiological Vascular Models
ResearchCo-Principal Investigator · Awarded by American Heart Association · 2022 - 2025An integrated microfluidic system with engineered blood vessel mimic and skeletal muscle to investigate the relation between rheumatoid arthritis and atherosclerosis
ResearchPrincipal Investigator · Awarded by International Foundation for Ethical Research · 2024 - 2025RFI_SSN(InVitro)-541715 Support for the Conduct of In Vitro Cardiovascular Toxicity Assays for the Division of Translational Toxicology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2025Leica Stellaris Confocal for a Campus-wide Shared Resource
EquipmentMajor User · Awarded by National Institutes of Health · 2024 - 2025Mechanotransduction in Meniscus Health and Repair
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024Microphysiological Human Tissue Systems for Monitoring of Genome Editing Outcomes
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2024Unified Program for Therapeutics in Children
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2019 - 2024Epigenetic Mechanisms Promoting Longevity
ResearchInvestigator · Awarded by National Institutes of Health · 2018 - 2024Human Microphysiological System to Study LINC Complex Mediated Force Imbalance in Progeria and Cardiovascular Diseases
FellowshipPrincipal Investigator · Awarded by American Heart Association · 2022 - 2023Cell-free mitochondrial DNA induces type I interferon production in an experimental myobundle model of juvenile dermatomyositis (JDM).
ResearchCo Investigator · Awarded by Cure JM Foundation · 2022 - 2023Atherosclerotic Risk of Branched Chain Amino Acids in a Tissue Engineered Blood Vessel Model
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2023Fabrication of Engineered Blood Vessel Perfusion Chambers
ResearchPrincipal Investigator · Awarded by Altos Labs, Inc. · 2022 - 2023Progeria and Vasculature: Investigating Genetic Effects and the Potential of Genome Editing for Treatment
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2023Acquisition of a Biacore T200 Surface Plasmon Resonance Instrument for Shared Use
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2022 - 2023Human Skeletal Muscle Model for Drug Discovery/Validation
ResearchPrincipal Investigator · Awarded by Novo Nordisk A/S · 2022 - 2023Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2022Faculty Springboard to Advance Breakthrough Science by Post-Tenure Faculty
Institutional SupportPrincipal Investigator · Awarded by National Science Foundation · 2018 - 2021TREK-1 in fibroblast differentiation and cardiac fibrosis development
ResearchCollaborator · Awarded by National Institutes of Health · 2015 - 2020Ex vivo metabolomic profiling of statin-induced myopathy
ResearchInvestigator · Awarded by American Heart Association · 2017 - 2019Developing An In Vitro Human Myobundle Model Of Rheumatoid Arthritis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019DukeMed Activated
Public ServiceSignificant Contributor · Awarded by National Institutes of Health · 2014 - 2019Visualizing and Elucidating Mechanisms of Mechanotransduction in Vascular Smooth Muscle Cells
ResearchCollaborator · Awarded by American Heart Association · 2016 - 2018Circulatory system and integrated muscle tissue for drug and tissue toxicity
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2018Using Aptamer Coated Nanoparticles Encapsulating Prostate Tumor Antigen Encoding mRNA to Target Dendritic Cells In Vivo
ResearchPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2012 - 2018Enhanced Design Experiences for Duke BME Students
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2017Effects of Chondroitin Sulfate and Chrondroitin Sulfate/Glucosamine on Muscle Immune Signaling and Function in TNF-alpha Stimulated Three Dimensional Muscle Cultures
ResearchPrincipal Investigator · Awarded by Bioiberica, S.A. · 2016 - 2017TREK-1 in fibroblast differentiation and cardiac fibrosis development
ResearchCollaborator · Awarded by American Heart Association · 2014 - 2015Endothelial Progenitor Cell Seeded Self-Expanding Vascular Stent
ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2015Engineering a Functional Skeletal Muscle
ResearchInvestigator · Awarded by National Institutes of Health · 2008 - 2014EPC Adhesion to Teflon-AF and ePTFE Vascular Grafts
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1990 - 2013MicroRNA Mediation of Stretch-Induced Myoblast Function for Engineered Tissues
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2013Endothelial Cell Adhesion and Function on Smooth Muscle
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2008 - 2013Autologous EPC lining to improve biocompatibility of circulatory assist devices
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2012Investigation of Anti-Angiogenic Mechanisms Using Novel Imaging Techniques
FellowshipPrincipal Investigator · Awarded by US Army Medical Research and Materiel Command · 2009 - 2012Optimizing and Evaluating an Integrated SPECT-CmT System Dedicated to Improved 3-D Breast Cancer Imaging
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2008 - 2010Breast Cancer Research Program (BCRP) Predoctoral Traineeship Award
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2007 - 2010Breast Cancer Research Program (BCRP) Predoctoral Traineeship Award
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2006 - 2009Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2006 - 2009Function of Endothelial Cell Integrins in Co-Culture
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2009Training in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009Early Detection of Breast Cancer via Multi-Plane Correlation Breast Imaging
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2006 - 2009Computer Aided Detection of Breast Masses in Digital Tomosynthesis
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2005 - 2008Flow Effects on Endothelial-Monocycle Interactions
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2008Computer-Aided Diagnosis System for Breast Cancer Combining Digital Mammography and Genomics
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2005 - 2008Optimization and Compression of Different Digital Mammographic Tomosynthesis Reconstruction Methods
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2006 - 2008Image Processing and Computer Aided Diagnosis in Computed Tomography of the Breast
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2005 - 2008Image Processing and Computer Aided Diagnosis in Computed Tomography of the Breast
FellowshipPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2005 - 2008Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1990 - 2008Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1990 - 2008Mechanical Stimulation of 2- and 3D Myoblast Culture
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007Mechanical Stimulation of 2- and 3-D Myoblast Culture
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007Flow Effects on Endothelial-Monocyte Interactions
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007Flow Effects on Endothelial-Monocyte Interactions
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007Development of a New Course: Design Projects in Cellular and Biomolecular Engineering
Institutional SupportPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2004 - 2006Student Design for People with Disabilities
Institutional SupportPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2004 - 2006Endothelial-Smooth Muscle Cell Interactions in Coculture
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2006Advanced Interconnect Laboratory
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2003 - 2005Infrared Spectroscopic Characterization of Melanins and Melanin-Containing Tissues and Development of a Non-Invasive Diagnostic Profile for Malignant Melanoma
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2003 - 2005Fabrication of Metal Nanoarray on Periodically Alligned DNA Template
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2003 - 2005A Colorimetric Colloidal Gold Sensor to Interrogate Biomolecular Interactions in Real-time on a Surface
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2003 - 2005Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Heart, Lung, and Blood Institute · 1999 - 2004Monocyte and LDL Dynamics During Early Atherogenesis
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 1988 - 2004Differentiation and maintenance of skeletal and cardiac muscle in simulated microgravity
ResearchCo Investigator · Awarded by National Aeronautics and Space Administration · 1999 - 2003Sickle Cell Adhesion
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1997 - 20032001 Annual Fall Meeting of the Biomedical Engineering Society
ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2002Graduate Student Research Proposal for Amy Collinsworth (Cytoskeletal Contributions to Changes in Elasticity of Mammalian Myocytes After Cyclic Mechanical Loading)
FellowshipPrincipal Investigator · Awarded by National Aeronautics and Space Administration · 1999 - 2001Flow Effect on Monocyte/Endothelial Cell Interaction
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2001Effect of Flow on Monocyte-endothelial Cell Interactions
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2000Laboratories in Biomolecular and Cellular Engineering
EquipmentPrincipal Investigator · Awarded by Division of Undergraduate Education · 1998 - 2000Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Heart, Lung, and Blood Institute (NHLBI) · 1990 - 2000same
ResearchCo Investigator · Awarded by National Aeronautics and Space Administration · 1995 - 1999Department of Biomedical Engineering Laboratory Upgrade, BME 101, 163, and 164
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 1998 - 1999LDL Transport in Arteries Following Endothelial Injury
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1999LDL Transport in Arteries Following Endothelial Injury
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1999Shear Stress and Calcium and Endothelial NO Release
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1998Shear Stress and Calcium and Endothelial NO Release
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1998Cell Shape and Growth Regulation by Micro-patterned Surfaces
ResearchPrincipal Investigator · Awarded by National Science Foundation · 1995 - 1998Regulation Of Skeletal Muscle Development And Differentiat
ResearchCo-Principal Investigator · Awarded by National Aeronautics and Space Administration · 1995 - 1997LDL Transport in Arteries Following Endothelial Injury
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1997Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1990 - 1996Endothelial Cell Adhesion to Polymers Studied by TIRF
ResearchCo-Principal Investigator · Awarded by National Heart, Lung, and Blood Institute (NHLBI) · 1990 - 1996Renovation of Room PO13 Teer
Construction/RenovationCo-Principal Investigator · Awarded by Lord Foundation of North Carolina · 1995 - 1996Hemodynamics and LDL Permeability in the Arterial Wall
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1993Hemodynamics and LDL Permeability in the Arterial Wall
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1993Hemodynamics and LDL Permeability in the Arterial Wall
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1988 - 1993External Relationships
- Advanced Micro Devices Inc
- Alphabet Inc
- Amazon, Inc
- Amgen, Inc.
- Apple Inc.
- BECTON DICKINSON
- Berkshire Hathaway, Inc.
- Blackrock Inc
- Blackstone Group Inc
- CARRIER GLOBAL CORPORATION
- CONSTELLATION ENERGY
- CUMMINS
- Charles Schwab and Vanguard Mutual Funds
- Citigroup, Inc.
- Costco
- Deere
- Durham Technical Community College
- ELEVANCE HEALTH
- Elsevier Inc.
- ExxonMobil
- General Dynamics
- IQVIA
- JP Morgan Chase
- Johnson & Johnson
- Lowes Companies
- MCDONALDS
- MCSI
- Medtronic
- Meta Platforms Inc
- Microsoft Corporation
- Monster Beverage
- NVIDIA
- Netflix
- Nextera Energy Inc
- Northrop Grumman
- Otis
- Pearson Education
- Prologis
- Thermo Fisher Scientific, Inc.
- United Health Group Inc
- Visa Inc Com CL A
- chubb limited
- palo alto networks inc
- salesforce
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.