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Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats.

Publication ,  Journal Article
Pyapali, GK; Dong, WQ; Deupree, DL; Bradley, J; Turner, DA
Published in: Restor Neurol Neurosci
January 1, 1994

Effects of fetal hippocampal transplants were evaluated following a prolonged intraventricular excitotoxic lesion (1.0 mg of N-methyl-D-aspartate over two weeks infusion) in F344 rats. The septum and ipsilateral hippocampus (CA1 and dentate regions) showed extensive cell loss, decreased acquisition of spatial memory was observed and a decrease in AChE positive fiber innervation to the hippocampus was noted following the lesion. Fetal hippocampal transplants into the posterior lateral ventricle resulted in moderate graft survival and physiological analysis of graft-host interconnection in vitro demonstrated evoked field potentials. However, the transplants did not lead to significant improvement in behavior, possibly due to poor synaptic integration of the intraventricular transplants into the host hippocampus. The prolonged intraventricular NMDA lesion may be helpful to understand a mixed lesion model of both septal areas and hippocampus and also as a background lesion in which to assess the connectivity and development of various types of neural grafts.

Duke Scholars

Published In

Restor Neurol Neurosci

DOI

ISSN

0922-6028

Publication Date

January 1, 1994

Volume

6

Issue

3

Start / End Page

251 / 256

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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MLA
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Pyapali, G. K., Dong, W. Q., Deupree, D. L., Bradley, J., & Turner, D. A. (1994). Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats. Restor Neurol Neurosci, 6(3), 251–256. https://doi.org/10.3233/RNN-1994-6308
Pyapali, G. K., W. Q. Dong, D. L. Deupree, J. Bradley, and D. A. Turner. “Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats.Restor Neurol Neurosci 6, no. 3 (January 1, 1994): 251–56. https://doi.org/10.3233/RNN-1994-6308.
Pyapali GK, Dong WQ, Deupree DL, Bradley J, Turner DA. Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats. Restor Neurol Neurosci. 1994 Jan 1;6(3):251–6.
Pyapali, G. K., et al. “Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats.Restor Neurol Neurosci, vol. 6, no. 3, Jan. 1994, pp. 251–56. Pubmed, doi:10.3233/RNN-1994-6308.
Pyapali GK, Dong WQ, Deupree DL, Bradley J, Turner DA. Influence of fetal hippocampal grafts on lesions induced by intraventricular infusion of N-methyl-D-aspartate (NMDA) into rats. Restor Neurol Neurosci. 1994 Jan 1;6(3):251–256.

Published In

Restor Neurol Neurosci

DOI

ISSN

0922-6028

Publication Date

January 1, 1994

Volume

6

Issue

3

Start / End Page

251 / 256

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences