Scholars@Duke publication: TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.

TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.

Publication , Journal Article

Yang, P; Li, Q-J; Feng, Y; Zhang, Y; Markowitz, GJ; Ning, S; Deng, Y; Zhao, J; Jiang, S; Yuan, Y; Wang, H-Y; Cheng, S-Q; Xie, D; Wang, X-F

Published in: Cancer Cell

September 11, 2012

Published version (DOI) Link to item

Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients with hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between hepatitis B virus (HBV) infection and development of PVTT. Mechanistically, elevated TGF-β activity, associated with the persistent presence of HBV in the liver tissue, suppresses the expression of microRNA-34a, leading to enhanced production of chemokine CCL22, which recruits regulatory T (Treg) cells to facilitate immune escape. These findings strongly suggest that HBV infection and activity of the TGF-β-miR-34a-CCL22 axis serve as potent etiological factors to predispose HCC patients for the development of PVTT, possibly through the creation of an immune-subversive microenvironment to favor colonization of disseminated HCC cells in the portal venous system.

Duke Scholars

Author Qi-Jing Li Integrative Immunobiology

Author Xiao-Fan Wang Pharmacology & Cancer Biology

Published In

Cancer Cell

DOI

10.1016/j.ccr.2012.07.023

EISSN

1878-3686

Publication Date

September 11, 2012

Volume

Issue

Start / End Page

291 / 303

Location

United States

Related Subject Headings

Tumor Microenvironment
Transforming Growth Factor beta
T-Lymphocytes, Regulatory
Signal Transduction
Portal Vein
Oncology & Carcinogenesis
Neoplasm Metastasis
Middle Aged
MicroRNAs
Mice, Nude

Citation

APA

Chicago

ICMJE

MLA

NLM

Yang, P., Li, Q.-J., Feng, Y., Zhang, Y., Markowitz, G. J., Ning, S., … Wang, X.-F. (2012). TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell, 22(3), 291–303. https://doi.org/10.1016/j.ccr.2012.07.023

Yang, Pengyuan, Qi-Jing Li, Yuxiong Feng, Yun Zhang, Geoffrey J. Markowitz, Shanglei Ning, Yuezhen Deng, et al. “TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.” Cancer Cell 22, no. 3 (September 11, 2012): 291–303. https://doi.org/10.1016/j.ccr.2012.07.023.

Yang P, Li Q-J, Feng Y, Zhang Y, Markowitz GJ, Ning S, et al. TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012 Sep 11;22(3):291–303.

Yang, Pengyuan, et al. “TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.” Cancer Cell, vol. 22, no. 3, Sept. 2012, pp. 291–303. Pubmed, doi:10.1016/j.ccr.2012.07.023.

Yang P, Li Q-J, Feng Y, Zhang Y, Markowitz GJ, Ning S, Deng Y, Zhao J, Jiang S, Yuan Y, Wang H-Y, Cheng S-Q, Xie D, Wang X-F. TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell. 2012 Sep 11;22(3):291–303.

Published In

Cancer Cell

DOI

10.1016/j.ccr.2012.07.023

EISSN

1878-3686

Publication Date

September 11, 2012

Volume

Issue

Start / End Page

291 / 303

Location

United States

Related Subject Headings

Tumor Microenvironment
Transforming Growth Factor beta
T-Lymphocytes, Regulatory
Signal Transduction
Portal Vein
Oncology & Carcinogenesis
Neoplasm Metastasis
Middle Aged
MicroRNAs
Mice, Nude