Smad5 induces ventral fates in Xenopus embryo.
Publication
, Journal Article
Suzuki, A; Chang, C; Yingling, JM; Wang, XF; Hemmati-Brivanlou, A
Published in: Dev Biol
April 15, 1997
The Smad proteins have been implicated in the intracellular signaling of transforming growth factor-beta (TGF-beta) ligands. Here we describe the function of Smad5 in early Xenopus development. Misexpression of Smad5 in the embryo causes ventralization and induces ventral mesoderm. Moreover, Smad5 induces epidermis in dissociated ectoderm cells which would otherwise form neural tissue. Both of these activities require Smad4 (DPC4) activity. We propose that Smad5 acts downstream of the BMP4 signaling pathway in Xenopus embryos and directs the formation of ventral mesoderm and epidermis.
Duke Scholars
Published In
Dev Biol
DOI
ISSN
0012-1606
Publication Date
April 15, 1997
Volume
184
Issue
2
Start / End Page
402 / 405
Location
United States
Related Subject Headings
- Xenopus Proteins
- Xenopus
- Trans-Activators
- Smad5 Protein
- Signal Transduction
- RNA
- Polymerase Chain Reaction
- Phosphoproteins
- Nucleic Acid Hybridization
- Mesoderm
Citation
APA
Chicago
ICMJE
MLA
NLM
Suzuki, A., Chang, C., Yingling, J. M., Wang, X. F., & Hemmati-Brivanlou, A. (1997). Smad5 induces ventral fates in Xenopus embryo. Dev Biol, 184(2), 402–405. https://doi.org/10.1006/dbio.1997.8548
Suzuki, A., C. Chang, J. M. Yingling, X. F. Wang, and A. Hemmati-Brivanlou. “Smad5 induces ventral fates in Xenopus embryo.” Dev Biol 184, no. 2 (April 15, 1997): 402–5. https://doi.org/10.1006/dbio.1997.8548.
Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A. Smad5 induces ventral fates in Xenopus embryo. Dev Biol. 1997 Apr 15;184(2):402–5.
Suzuki, A., et al. “Smad5 induces ventral fates in Xenopus embryo.” Dev Biol, vol. 184, no. 2, Apr. 1997, pp. 402–05. Pubmed, doi:10.1006/dbio.1997.8548.
Suzuki A, Chang C, Yingling JM, Wang XF, Hemmati-Brivanlou A. Smad5 induces ventral fates in Xenopus embryo. Dev Biol. 1997 Apr 15;184(2):402–405.
Published In
Dev Biol
DOI
ISSN
0012-1606
Publication Date
April 15, 1997
Volume
184
Issue
2
Start / End Page
402 / 405
Location
United States
Related Subject Headings
- Xenopus Proteins
- Xenopus
- Trans-Activators
- Smad5 Protein
- Signal Transduction
- RNA
- Polymerase Chain Reaction
- Phosphoproteins
- Nucleic Acid Hybridization
- Mesoderm