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Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs.

Publication ,  Journal Article
Stokes, AM; Wilson, JW; Warren, WS
Published in: Journal of magnetic resonance (San Diego, Calif. : 1997)
October 2012

Improved understanding of the entrapment, transport, and release of drugs and small molecules within vesicles is important for drug delivery. Most methods rely on contrast agents or probe molecules; here, we propose a new MRI method to detect signal from water spins with restricted diffusion. This method is based on intermolecular double quantum coherences (iDQCs), which can probe the restricted diffusion characteristics at well-defined and tunable microscopic distance scales. By using an exceedingly short (and previously inaccessible) distance, the iDQC signal arises only from restricted diffusion spins and thereby provides a mechanism to directly image vesicle entrapment, transport, and release. Using uni- and multi-lamellar liposomes and polymersomes, we show how the composition, lamellar structure, vesicle size, and concentration affects the iDQC signal between coupled water spins at very short separation distances. The iDQC signal correlates well with conventional diffusion MRI and a proposed biexponential (multicompartmental) diffusion model. Finally, the iDQC signal was used to monitor dynamic changes in the lamellar structure as temperature-sensitive liposomes released their contents. These short distance iDQCs can probe the amount and diffusion of water entrapped in vesicles, which may be useful to further understand vesicle properties in materials science and drug delivery applications.

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Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

October 2012

Volume

223

Start / End Page

31 / 40

Related Subject Headings

  • Water
  • Quantum Theory
  • Polymers
  • Particle Size
  • Magnetic Resonance Imaging
  • Liposomes
  • Lipids
  • Drug Delivery Systems
  • Drug Carriers
  • Diffusion
 

Citation

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Stokes, A. M., Wilson, J. W., & Warren, W. S. (2012). Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. Journal of Magnetic Resonance (San Diego, Calif. : 1997), 223, 31–40. https://doi.org/10.1016/j.jmr.2012.07.021
Stokes, A. M., J. W. Wilson, and W. S. Warren. “Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs.Journal of Magnetic Resonance (San Diego, Calif. : 1997) 223 (October 2012): 31–40. https://doi.org/10.1016/j.jmr.2012.07.021.
Stokes AM, Wilson JW, Warren WS. Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. Journal of magnetic resonance (San Diego, Calif : 1997). 2012 Oct;223:31–40.
Stokes, A. M., et al. “Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs.Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 223, Oct. 2012, pp. 31–40. Epmc, doi:10.1016/j.jmr.2012.07.021.
Stokes AM, Wilson JW, Warren WS. Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. Journal of magnetic resonance (San Diego, Calif : 1997). 2012 Oct;223:31–40.
Journal cover image

Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

October 2012

Volume

223

Start / End Page

31 / 40

Related Subject Headings

  • Water
  • Quantum Theory
  • Polymers
  • Particle Size
  • Magnetic Resonance Imaging
  • Liposomes
  • Lipids
  • Drug Delivery Systems
  • Drug Carriers
  • Diffusion