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Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.

Publication ,  Journal Article
Warren, WS; Richter, W; Andreotti, AH; Farmer, BT
Published in: Science (New York, N.Y.)
December 1993

Intermolecular multiple-quantum coherences between bulk water and a glycoprotein fragment at modest concentration (20 mM) have been experimentally produced and detected, although such coherences are inconceivable in the normal theoretical framework of nuclear magnetic resonance. A density matrix treatment explains these results by including the long-range dipolar interaction between spins and by discarding the high-temperature approximation. These results imply that peak intensities (critical for structural determinations) can be distorted in many gradient experiments, and show that magic-angle gradients provide substantial improvements with reduced gradient strengths. They also suggest methods for contrast enhancement in magnetic resonance imaging.

Duke Scholars

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

December 1993

Volume

262

Issue

5142

Start / End Page

2005 / 2009

Related Subject Headings

  • Water
  • Solutions
  • Peptide Fragments
  • Models, Chemical
  • Magnetic Resonance Spectroscopy
  • General Science & Technology
  • Fibronectins
 

Citation

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MLA
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Warren, W. S., Richter, W., Andreotti, A. H., & Farmer, B. T. (1993). Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science (New York, N.Y.), 262(5142), 2005–2009. https://doi.org/10.1126/science.8266096
Warren, W. S., W. Richter, A. H. Andreotti, and B. T. Farmer. “Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.Science (New York, N.Y.) 262, no. 5142 (December 1993): 2005–9. https://doi.org/10.1126/science.8266096.
Warren WS, Richter W, Andreotti AH, Farmer BT. Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science (New York, NY). 1993 Dec;262(5142):2005–9.
Warren, W. S., et al. “Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR.Science (New York, N.Y.), vol. 262, no. 5142, Dec. 1993, pp. 2005–09. Epmc, doi:10.1126/science.8266096.
Warren WS, Richter W, Andreotti AH, Farmer BT. Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science (New York, NY). 1993 Dec;262(5142):2005–2009.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

December 1993

Volume

262

Issue

5142

Start / End Page

2005 / 2009

Related Subject Headings

  • Water
  • Solutions
  • Peptide Fragments
  • Models, Chemical
  • Magnetic Resonance Spectroscopy
  • General Science & Technology
  • Fibronectins