Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.
Publication
, Journal Article
Foulon, CF; Schoultz, BW; Zalutsky, MR
Published in: Nucl Med Biol
February 1997
Biotinyl-3-[211 At]astatoanilide ([211 At]AtBA) was prepared in more than 80% yield by destannylation. In vitro, [211 At]AtBA exhibited a high affinity for streptavidin, and was stable after incubation in human serum, cerebrospinal fluid and distilled water, whereas it was rapidly degraded in mouse serum. HPLC analysis showed that the main degradation pathway in mouse serum was the cleavage of [211 At]astatoaniline. In mice, [211 At]AtBA and its 125I-labeled analogue cleared rapidly from most tissues; however, there was some evidence for dehalogenation of both tracers.
Duke Scholars
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Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
February 1997
Volume
24
Issue
2
Start / End Page
135 / 143
Location
United States
Related Subject Headings
- Tissue Distribution
- Time Factors
- Nuclear Medicine & Medical Imaging
- Mice
- Kinetics
- Iodine Radioisotopes
- Humans
- Drug Stability
- Biotransformation
- Biotin
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NLM
Foulon, C. F., Schoultz, B. W., & Zalutsky, M. R. (1997). Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. Nucl Med Biol, 24(2), 135–143. https://doi.org/10.1016/s0969-8051(96)00185-0
Foulon, C. F., B. W. Schoultz, and M. R. Zalutsky. “Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.” Nucl Med Biol 24, no. 2 (February 1997): 135–43. https://doi.org/10.1016/s0969-8051(96)00185-0.
Foulon CF, Schoultz BW, Zalutsky MR. Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. Nucl Med Biol. 1997 Feb;24(2):135–43.
Foulon, C. F., et al. “Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide.” Nucl Med Biol, vol. 24, no. 2, Feb. 1997, pp. 135–43. Pubmed, doi:10.1016/s0969-8051(96)00185-0.
Foulon CF, Schoultz BW, Zalutsky MR. Preparation and biological evaluation of an astatine-211 labeled biotin conjugate: biotinyl-3-[211 At]astatoanilide. Nucl Med Biol. 1997 Feb;24(2):135–143.
Published In
Nucl Med Biol
DOI
ISSN
0969-8051
Publication Date
February 1997
Volume
24
Issue
2
Start / End Page
135 / 143
Location
United States
Related Subject Headings
- Tissue Distribution
- Time Factors
- Nuclear Medicine & Medical Imaging
- Mice
- Kinetics
- Iodine Radioisotopes
- Humans
- Drug Stability
- Biotransformation
- Biotin