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Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction

Publication ,  Journal Article
Larsen, RH; Wieland, BW; Zalutsky, MR
Published in: Applied Radiation and Isotopes
1996

Astatine-211 is a 7.2 h half-life α-emitting radionuclide which has shown great promise for targeted radiotherapy. It is generally produced by cyclotron bombardment of bismuth metal targets with 28 MeV α-particles via the 209Bi(α, 2n)211At reaction. In order to provide 211At activity levels anticipated for clinical investigations, an internal target system has been designed and evaluated. The system has a grazing-angle configuration and leading- and trailing-edge monitors. Both aluminum and copper target backings were evaluated. With approx. 28 MeV α-particles, the 211At production efficiency was 41 ± 7 MBq/μA·h, compared with 10.6 ± 1.2 MBq/μA·h for an external target. Radionuclidic purity of 211At was high with no evidence of 210At. Copyright © 1996 Elsevier Science Ltd. All rights reserved.

Duke Scholars

Published In

Applied Radiation and Isotopes

Publication Date

1996

Volume

47

Issue

2

Start / End Page

135 / 143

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics
 

Citation

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MLA
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Larsen, R. H., Wieland, B. W., & Zalutsky, M. R. (1996). Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction. Applied Radiation and Isotopes, 47(2), 135–143.
Larsen, R. H., B. W. Wieland, and M. R. Zalutsky. “Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction.” Applied Radiation and Isotopes 47, no. 2 (1996): 135–43.
Larsen RH, Wieland BW, Zalutsky MR. Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction. Applied Radiation and Isotopes. 1996;47(2):135–43.
Larsen, R. H., et al. “Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction.” Applied Radiation and Isotopes, vol. 47, no. 2, 1996, pp. 135–43.
Larsen RH, Wieland BW, Zalutsky MR. Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction. Applied Radiation and Isotopes. 1996;47(2):135–143.

Published In

Applied Radiation and Isotopes

Publication Date

1996

Volume

47

Issue

2

Start / End Page

135 / 143

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences
  • 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics