Scholars@Duke publication: Evaluation of an internal cyclotron target for the production of 211at via the 209Bi (α,2n)211at reaction

Evaluation of an internal cyclotron target for the production of ²¹¹at via the ²⁰⁹Bi (α,2n)²¹¹at reaction

Publication , Journal Article

Larsen, RH; Wieland, BW; Zalutsky, MR

Published in: Applied Radiation and Isotopes

1996

Astatine-211 is a 7.2 h half-life α-emitting radionuclide which has shown great promise for targeted radiotherapy. It is generally produced by cyclotron bombardment of bismuth metal targets with 28 MeV α-particles via the 209Bi(α, 2n)211At reaction. In order to provide 211At activity levels anticipated for clinical investigations, an internal target system has been designed and evaluated. The system has a grazing-angle configuration and leading- and trailing-edge monitors. Both aluminum and copper target backings were evaluated. With approx. 28 MeV α-particles, the 211At production efficiency was 41 ± 7 MBq/μA·h, compared with 10.6 ± 1.2 MBq/μA·h for an external target. Radionuclidic purity of 211At was high with no evidence of 210At. Copyright © 1996 Elsevier Science Ltd. All rights reserved.

Duke Scholars

Author Michael Rod Zalutsky Radiology

Published In

Applied Radiation and Isotopes

Publication Date

1996

Volume

Issue

Start / End Page

135 / 143

Related Subject Headings

Nuclear Medicine & Medical Imaging
1103 Clinical Sciences
0299 Other Physical Sciences
0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics

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Larsen, R. H., Wieland, B. W., & Zalutsky, M. R. (1996). Evaluation of an internal cyclotron target for the production of ²¹¹at via the ²⁰⁹Bi (α,2n)²¹¹at reaction. Applied Radiation and Isotopes, 47(2), 135–143.

Larsen, R. H., B. W. Wieland, and M. R. Zalutsky. “Evaluation of an internal cyclotron target for the production of ²¹¹at via the ²⁰⁹Bi (α,2n)²¹¹at reaction.” Applied Radiation and Isotopes 47, no. 2 (1996): 135–43.

Larsen RH, Wieland BW, Zalutsky MR. Evaluation of an internal cyclotron target for the production of ²¹¹at via the ²⁰⁹Bi (α,2n)²¹¹at reaction. Applied Radiation and Isotopes. 1996;47(2):135–43.

Larsen, R. H., et al. “Evaluation of an internal cyclotron target for the production of ²¹¹at via the ²⁰⁹Bi (α,2n)²¹¹at reaction.” Applied Radiation and Isotopes, vol. 47, no. 2, 1996, pp. 135–43.