Skip to main content

Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.

Publication ,  Journal Article
Bielefeld, KA; Amini-Nik, S; Whetstone, H; Poon, R; Youn, A; Wang, J; Alman, BA
Published in: J Biol Chem
August 5, 2011

β-Catenin is an important regulator of dermal fibroblasts during cutaneous wound repair. However, the factors that modulate β-catenin activity in this process are not completely understood. We investigated the role of the extracellular matrix in regulating β-catenin and found an increase in β-catenin-mediated Tcf-dependent transcriptional activity in fibroblasts exposed to various extracellular matrix components. This occurs through an integrin-mediated GSK3β-dependent pathway. The physiologic role of this mechanism was demonstrated during wound repair in extra domain A-fibronectin-deficient mice, which exhibited decreased β-catenin-mediated signaling during the proliferative phase of healing. Extra domain A-fibronectin-deficient mice have wounds that fail at a lower tensile strength and contain fewer fibroblasts compared with wild type mice. This phenotype was rescued by genetic or pharmacologic activation of β-catenin signaling. Because fibronectin is a transcriptional target of β-catenin, this suggests the existence of a feedback loop between these two molecules that regulates dermal fibroblast cell behavior during wound repair.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

August 5, 2011

Volume

286

Issue

31

Start / End Page

27687 / 27697

Location

United States

Related Subject Headings

  • beta Catenin
  • Wound Healing
  • Skin
  • Signal Transduction
  • Mice, Knockout
  • Mice
  • Immunohistochemistry
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3
  • Fibronectins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bielefeld, K. A., Amini-Nik, S., Whetstone, H., Poon, R., Youn, A., Wang, J., & Alman, B. A. (2011). Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem, 286(31), 27687–27697. https://doi.org/10.1074/jbc.M111.261677
Bielefeld, Kirsten A., Saeid Amini-Nik, Heather Whetstone, Raymond Poon, Andrew Youn, Jian Wang, and Benjamin A. Alman. “Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.J Biol Chem 286, no. 31 (August 5, 2011): 27687–97. https://doi.org/10.1074/jbc.M111.261677.
Bielefeld KA, Amini-Nik S, Whetstone H, Poon R, Youn A, Wang J, et al. Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem. 2011 Aug 5;286(31):27687–97.
Bielefeld, Kirsten A., et al. “Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing.J Biol Chem, vol. 286, no. 31, Aug. 2011, pp. 27687–97. Pubmed, doi:10.1074/jbc.M111.261677.
Bielefeld KA, Amini-Nik S, Whetstone H, Poon R, Youn A, Wang J, Alman BA. Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem. 2011 Aug 5;286(31):27687–27697.

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

August 5, 2011

Volume

286

Issue

31

Start / End Page

27687 / 27697

Location

United States

Related Subject Headings

  • beta Catenin
  • Wound Healing
  • Skin
  • Signal Transduction
  • Mice, Knockout
  • Mice
  • Immunohistochemistry
  • Glycogen Synthase Kinase 3 beta
  • Glycogen Synthase Kinase 3
  • Fibronectins