Skip to main content
Journal cover image

Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.

Publication ,  Journal Article
McNamara, JO; Peper, AM; Patrone, V
Published in: Proc Natl Acad Sci U S A
May 1980

Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats. Scatchard analyses demonstrated that increased numbers of binding sites accounted for the increase. Neither repeated hypoxia nor repeated administration of electrical current without inducing seizures caused an increase of [3H]diazepam binding. Regardless of the method used for seizure induction, the response was graded in that large numbers of seizures were required to induce significant increases, whereas fewer seizures induced only slight increases. We suggest that the receptor increases imply a heightened response to benzodiazepines and more powerful hippocampal recurrent inhibition.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

May 1980

Volume

77

Issue

5

Start / End Page

3029 / 3032

Location

United States

Related Subject Headings

  • Seizures
  • Receptors, Drug
  • Rats
  • Male
  • Kinetics
  • Hippocampus
  • Epilepsy
  • Electroshock
  • Disease Models, Animal
  • Diazepam
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McNamara, J. O., Peper, A. M., & Patrone, V. (1980). Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. Proc Natl Acad Sci U S A, 77(5), 3029–3032. https://doi.org/10.1073/pnas.77.5.3029
McNamara, J. O., A. M. Peper, and V. Patrone. “Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.Proc Natl Acad Sci U S A 77, no. 5 (May 1980): 3029–32. https://doi.org/10.1073/pnas.77.5.3029.
McNamara JO, Peper AM, Patrone V. Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. Proc Natl Acad Sci U S A. 1980 May;77(5):3029–32.
McNamara, J. O., et al. “Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.Proc Natl Acad Sci U S A, vol. 77, no. 5, May 1980, pp. 3029–32. Pubmed, doi:10.1073/pnas.77.5.3029.
McNamara JO, Peper AM, Patrone V. Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. Proc Natl Acad Sci U S A. 1980 May;77(5):3029–3032.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

May 1980

Volume

77

Issue

5

Start / End Page

3029 / 3032

Location

United States

Related Subject Headings

  • Seizures
  • Receptors, Drug
  • Rats
  • Male
  • Kinetics
  • Hippocampus
  • Epilepsy
  • Electroshock
  • Disease Models, Animal
  • Diazepam