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Light uncages a copper complex to induce nonapoptotic cell death.

Publication ,  Journal Article
Kumbhar, AA; Franks, AT; Butcher, RJ; Franz, KJ
Published in: Chemical communications (Cambridge, England)
March 2013

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Duke Scholars

Published In

Chemical communications (Cambridge, England)

DOI

EISSN

1364-548X

ISSN

1359-7345

Publication Date

March 2013

Volume

49

Issue

24

Start / End Page

2460 / 2462

Related Subject Headings

  • Ultraviolet Rays
  • Organic Chemistry
  • Molecular Conformation
  • MCF-7 Cells
  • Ligands
  • Hydrogen Peroxide
  • Humans
  • Hela Cells
  • HeLa Cells
  • HL-60 Cells
 

Citation

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Kumbhar, A. A., Franks, A. T., Butcher, R. J., & Franz, K. J. (2013). Light uncages a copper complex to induce nonapoptotic cell death. Chemical Communications (Cambridge, England), 49(24), 2460–2462. https://doi.org/10.1039/c3cc38927h
Kumbhar, Anupa A., Andrew T. Franks, Raymond J. Butcher, and Katherine J. Franz. “Light uncages a copper complex to induce nonapoptotic cell death.Chemical Communications (Cambridge, England) 49, no. 24 (March 2013): 2460–62. https://doi.org/10.1039/c3cc38927h.
Kumbhar AA, Franks AT, Butcher RJ, Franz KJ. Light uncages a copper complex to induce nonapoptotic cell death. Chemical communications (Cambridge, England). 2013 Mar;49(24):2460–2.
Kumbhar, Anupa A., et al. “Light uncages a copper complex to induce nonapoptotic cell death.Chemical Communications (Cambridge, England), vol. 49, no. 24, Mar. 2013, pp. 2460–62. Epmc, doi:10.1039/c3cc38927h.
Kumbhar AA, Franks AT, Butcher RJ, Franz KJ. Light uncages a copper complex to induce nonapoptotic cell death. Chemical communications (Cambridge, England). 2013 Mar;49(24):2460–2462.
Journal cover image

Published In

Chemical communications (Cambridge, England)

DOI

EISSN

1364-548X

ISSN

1359-7345

Publication Date

March 2013

Volume

49

Issue

24

Start / End Page

2460 / 2462

Related Subject Headings

  • Ultraviolet Rays
  • Organic Chemistry
  • Molecular Conformation
  • MCF-7 Cells
  • Ligands
  • Hydrogen Peroxide
  • Humans
  • Hela Cells
  • HeLa Cells
  • HL-60 Cells