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Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more.

Publication ,  Journal Article
Hoveyda, AH; Malcolmson, SJ; Meek, SJ; Zhugralin, AR
Published in: Angewandte Chemie (International ed. in English)
January 2010

Chiral olefin metathesis catalysts enable chemists to access enantiomerically enriched small molecules with high efficiency; synthesis schemes involving such complexes can be substantially more concise than those that would involve enantiomerically pure substrates and achiral Mo alkylidenes or Ru-based carbenes. The scope of research towards design and development of chiral catalysts is not limited to discovery of complexes that are merely the chiral versions of the related achiral variants. A chiral olefin metathesis catalyst, in addition to furnishing products of high enantiomeric purity, can offer levels of efficiency, product selectivity and/or olefin stereoselectivity that are unavailable through the achiral variants. Such positive attributes of chiral catalysts (whether utilized in racemic or enantiomerically enriched form) should be considered as general, applicable to other classes of transformations.

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Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

January 2010

Volume

49

Issue

1

Start / End Page

34 / 44

Related Subject Headings

  • Stereoisomerism
  • Organic Chemistry
  • Methane
  • Metals
  • Coordination Complexes
  • Catalysis
  • Biological Products
  • Anti-HIV Agents
  • Alkenes
  • 34 Chemical sciences
 

Citation

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Hoveyda, A. H., Malcolmson, S. J., Meek, S. J., & Zhugralin, A. R. (2010). Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more. Angewandte Chemie (International Ed. in English), 49(1), 34–44. https://doi.org/10.1002/anie.200904491
Hoveyda, Amir H., Steven J. Malcolmson, Simon J. Meek, and Adil R. Zhugralin. “Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more.Angewandte Chemie (International Ed. in English) 49, no. 1 (January 2010): 34–44. https://doi.org/10.1002/anie.200904491.
Hoveyda AH, Malcolmson SJ, Meek SJ, Zhugralin AR. Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more. Angewandte Chemie (International ed in English). 2010 Jan;49(1):34–44.
Hoveyda, Amir H., et al. “Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more.Angewandte Chemie (International Ed. in English), vol. 49, no. 1, Jan. 2010, pp. 34–44. Epmc, doi:10.1002/anie.200904491.
Hoveyda AH, Malcolmson SJ, Meek SJ, Zhugralin AR. Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more. Angewandte Chemie (International ed in English). 2010 Jan;49(1):34–44.
Journal cover image

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

January 2010

Volume

49

Issue

1

Start / End Page

34 / 44

Related Subject Headings

  • Stereoisomerism
  • Organic Chemistry
  • Methane
  • Metals
  • Coordination Complexes
  • Catalysis
  • Biological Products
  • Anti-HIV Agents
  • Alkenes
  • 34 Chemical sciences