Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis.
Publication
, Journal Article
Pentchev, PG; Gal, AE; Wong, R; Morrone, S; Neumeyer, B; Massey, J; Kanter, R; Sawitsky, A; Brady, RO
Published in: Biochim Biophys Acta
September 24, 1981
Metabolically inert L-[1-14C]glucosylceramide is stored predominantly in the liver after intravenous administration to mice. The half-time of this glycolipid analogue in the liver is 3.5 days and its clearance occurs predominantly via the bile. Within the limited number of Gaucher specimens available for examination very high levels of glucosylceramide were found in the bile of one patient and in the liver of two patients with biliary obstruction. The question of a possible relationship between biliary excretion of glycolipid and the pathogenesis of Gaucher's disease will require further studies.
Duke Scholars
Published In
Biochim Biophys Acta
DOI
ISSN
0006-3002
Publication Date
September 24, 1981
Volume
665
Issue
3
Start / End Page
615 / 618
Location
Netherlands
Related Subject Headings
- Mice
- Liver
- Kinetics
- Isomerism
- Humans
- Half-Life
- Glycolipids
- Glucosylceramides
- Gaucher Disease
- Cerebrosides
Citation
APA
Chicago
ICMJE
MLA
NLM
Pentchev, P. G., Gal, A. E., Wong, R., Morrone, S., Neumeyer, B., Massey, J., … Brady, R. O. (1981). Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. Biochim Biophys Acta, 665(3), 615–618. https://doi.org/10.1016/0005-2760(81)90279-4
Pentchev, P. G., A. E. Gal, R. Wong, S. Morrone, B. Neumeyer, J. Massey, R. Kanter, A. Sawitsky, and R. O. Brady. “Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis.” Biochim Biophys Acta 665, no. 3 (September 24, 1981): 615–18. https://doi.org/10.1016/0005-2760(81)90279-4.
Pentchev PG, Gal AE, Wong R, Morrone S, Neumeyer B, Massey J, et al. Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. Biochim Biophys Acta. 1981 Sep 24;665(3):615–8.
Pentchev, P. G., et al. “Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis.” Biochim Biophys Acta, vol. 665, no. 3, Sept. 1981, pp. 615–18. Pubmed, doi:10.1016/0005-2760(81)90279-4.
Pentchev PG, Gal AE, Wong R, Morrone S, Neumeyer B, Massey J, Kanter R, Sawitsky A, Brady RO. Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. Biochim Biophys Acta. 1981 Sep 24;665(3):615–618.
Published In
Biochim Biophys Acta
DOI
ISSN
0006-3002
Publication Date
September 24, 1981
Volume
665
Issue
3
Start / End Page
615 / 618
Location
Netherlands
Related Subject Headings
- Mice
- Liver
- Kinetics
- Isomerism
- Humans
- Half-Life
- Glycolipids
- Glucosylceramides
- Gaucher Disease
- Cerebrosides