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Development of angle-resolved low coherence interferometry for clinical detection of dysplasia.

Publication ,  Journal Article
Zhu, Y; Terry, NG; Wax, A
Published in: Journal of carcinogenesis
January 2011

This review covers the development of angle-resolved low coherence interferometry (a/LCI) from initial development through clinical application. In the first applications, the approach used a time-domain interferometry scheme and was validated using animal models of carcinogenesis to assess the feasibility of detecting dysplasia in situ. Further development of the approach led to Fourier-domain interferometry schemes with higher throughput and endoscope-compatible probes to enable clinical application. These later implementations have been applied to clinical studies of dysplasia in Barrett's esophagus tissues, a metaplastic tissue type that is associated with an increased risk of esophageal adenocarcinoma. As an alternative to systematic biopsy, the a/LCI approach offers high sensitivity and specificity for detecting dysplasia in these tissues while avoiding the need for tissue removal or exogenous contrast agents. Here, the various implementations of a/LCI are discussed and the results of the preliminary animal experiments and ex vivo human tissue studies are reviewed. A review of a recent in vivo clinical study is also presented.

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Published In

Journal of carcinogenesis

DOI

EISSN

1477-3163

ISSN

1477-3163

Publication Date

January 2011

Volume

10

Start / End Page

19

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Zhu, Y., Terry, N. G., & Wax, A. (2011). Development of angle-resolved low coherence interferometry for clinical detection of dysplasia. Journal of Carcinogenesis, 10, 19. https://doi.org/10.4103/1477-3163.83935
Zhu, Yizheng, Neil G. Terry, and Adam Wax. “Development of angle-resolved low coherence interferometry for clinical detection of dysplasia.Journal of Carcinogenesis 10 (January 2011): 19. https://doi.org/10.4103/1477-3163.83935.
Zhu Y, Terry NG, Wax A. Development of angle-resolved low coherence interferometry for clinical detection of dysplasia. Journal of carcinogenesis. 2011 Jan;10:19.
Zhu, Yizheng, et al. “Development of angle-resolved low coherence interferometry for clinical detection of dysplasia.Journal of Carcinogenesis, vol. 10, Jan. 2011, p. 19. Epmc, doi:10.4103/1477-3163.83935.
Zhu Y, Terry NG, Wax A. Development of angle-resolved low coherence interferometry for clinical detection of dysplasia. Journal of carcinogenesis. 2011 Jan;10:19.

Published In

Journal of carcinogenesis

DOI

EISSN

1477-3163

ISSN

1477-3163

Publication Date

January 2011

Volume

10

Start / End Page

19

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis