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Engineering skeletal muscle repair.

Publication ,  Journal Article
Juhas, M; Bursac, N
Published in: Current opinion in biotechnology
October 2013

Healthy skeletal muscle has a remarkable capacity for regeneration. Even at a mature age, muscle tissue can undergo a robust rebuilding process that involves the formation of new muscle cells and extracellular matrix and the re-establishment of vascular and neural networks. Understanding and reverse-engineering components of this process is essential for our ability to restore loss of muscle mass and function in cases where the natural ability of muscle for self-repair is exhausted or impaired. In this article, we will describe current approaches to restore the function of diseased or injured muscle through combined use of myogenic stem cells, biomaterials, and functional tissue-engineered muscle. Furthermore, we will discuss possibilities for expanding the future use of human cell sources toward the development of cell-based clinical therapies and in vitro models of human muscle disease.

Duke Scholars

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Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

October 2013

Volume

24

Issue

5

Start / End Page

880 / 886

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Satellite Cells, Skeletal Muscle
  • Regeneration
  • Muscle, Skeletal
  • Models, Biological
  • Humans
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology
 

Citation

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Juhas, M., & Bursac, N. (2013). Engineering skeletal muscle repair. Current Opinion in Biotechnology, 24(5), 880–886. https://doi.org/10.1016/j.copbio.2013.04.013
Juhas, Mark, and Nenad Bursac. “Engineering skeletal muscle repair.Current Opinion in Biotechnology 24, no. 5 (October 2013): 880–86. https://doi.org/10.1016/j.copbio.2013.04.013.
Juhas M, Bursac N. Engineering skeletal muscle repair. Current opinion in biotechnology. 2013 Oct;24(5):880–6.
Juhas, Mark, and Nenad Bursac. “Engineering skeletal muscle repair.Current Opinion in Biotechnology, vol. 24, no. 5, Oct. 2013, pp. 880–86. Epmc, doi:10.1016/j.copbio.2013.04.013.
Juhas M, Bursac N. Engineering skeletal muscle repair. Current opinion in biotechnology. 2013 Oct;24(5):880–886.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

October 2013

Volume

24

Issue

5

Start / End Page

880 / 886

Related Subject Headings

  • Wound Healing
  • Tissue Engineering
  • Satellite Cells, Skeletal Muscle
  • Regeneration
  • Muscle, Skeletal
  • Models, Biological
  • Humans
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology