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Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States.

Publication ,  Journal Article
Frank, SJ; Grimm, PD; Sylvester, JE; Merrick, GS; Davis, BJ; Zietman, A; Moran, BJ; Beyer, DC; Roach, M; Clarke, DH; Stock, RG; Robert Lee, W ...
Published in: Brachytherapy
2007

PURPOSE: This study is aimed at understanding and defining the current patterns of care with respect to prostate brachytherapy for patients with intermediate-risk localized disease in the combined academic and community setting. METHODS AND MATERIALS: A nomogram-based survey was developed at the Seattle Prostate Institute defining the accepted criteria for intermediate-risk prostate cancer. Patients were defined as having intermediate-risk prostate cancer if they met one of the following criteria: prostate-specific antigen (PSA) >10 ng/dL, Gleason score (GS) > or = 7, or cT2b or cT2c disease. Additional potential predictive factors including perineural invasion (PNI), GS 3+4 vs. 4+3, and high-volume disease were included. RESULTS: In the absence of PNI, all of those surveyed would perform monotherapy for intermediate-risk patients, GS 7 (3+4) or PSA 10-20, with cT1c and <30% cores +. Up to 80% would perform monotherapy for patients with cT1c, GS 7 (4+3), and <30% cores +. Eighty to 90% of physicians would perform an implant alone with cT2a and either a PSA of 10-20 or GS of 7 (3+4) and <30% cores +. Fifty to 60% of those surveyed stated that they would treat a patient with cT2b disease, GS 7 (3+4), or PSA 11-20, with less than two-thirds of the biopsy cores positive in the absence of PNI. CONCLUSIONS: This Patterns of Care (POC) study reveals that certain subsets of intermediate-risk localized prostate cancer patients are considered appropriate candidates for an interstitial implant alone.

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Published In

Brachytherapy

DOI

ISSN

1538-4721

Publication Date

2007

Volume

6

Issue

1

Start / End Page

2 / 8

Location

United States

Related Subject Headings

  • United States
  • Risk
  • Retrospective Studies
  • Prostatic Neoplasms
  • Practice Patterns, Physicians'
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Male
  • Iodine Radioisotopes
 

Citation

APA
Chicago
ICMJE
MLA
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Frank, S. J., Grimm, P. D., Sylvester, J. E., Merrick, G. S., Davis, B. J., Zietman, A., … Blasko, J. C. (2007). Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States. Brachytherapy, 6(1), 2–8. https://doi.org/10.1016/j.brachy.2006.09.004
Frank, Steven J., Peter D. Grimm, John E. Sylvester, Gregory S. Merrick, Brian J. Davis, Anthony Zietman, Brian J. Moran, et al. “Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States.Brachytherapy 6, no. 1 (2007): 2–8. https://doi.org/10.1016/j.brachy.2006.09.004.
Frank, Steven J., et al. “Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States.Brachytherapy, vol. 6, no. 1, 2007, pp. 2–8. Pubmed, doi:10.1016/j.brachy.2006.09.004.
Frank SJ, Grimm PD, Sylvester JE, Merrick GS, Davis BJ, Zietman A, Moran BJ, Beyer DC, Roach M, Clarke DH, Stock RG, Robert Lee W, Michalski JM, Wallner KE, Hurwitz M, Potters L, Kuban DA, Prestidge BR, Vera R, Hathaway S, Blasko JC. Interstitial implant alone or in combination with external beam radiation therapy for intermediate-risk prostate cancer: a survey of practice patterns in the United States. Brachytherapy. 2007;6(1):2–8.
Journal cover image

Published In

Brachytherapy

DOI

ISSN

1538-4721

Publication Date

2007

Volume

6

Issue

1

Start / End Page

2 / 8

Location

United States

Related Subject Headings

  • United States
  • Risk
  • Retrospective Studies
  • Prostatic Neoplasms
  • Practice Patterns, Physicians'
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Male
  • Iodine Radioisotopes