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Pump-probe nonlinear phase dispersion spectroscopy.

Publication ,  Journal Article
Robles, FE; Samineni, P; Wilson, JW; Warren, WS
Published in: Optics express
April 2013

Pump-probe microscopy is an imaging technique that delivers molecular contrast of pigmented samples. Here, we introduce pump-probe nonlinear phase dispersion spectroscopy (PP-NLDS), a method that leverages pump-probe microscopy and spectral-domain interferometry to ascertain information from dispersive and resonant nonlinear effects. PP-NLDS extends the information content to four dimensions (phase, amplitude, wavelength, and pump-probe time-delay) that yield unique insight into a wider range of nonlinear interactions compared to conventional methods. This results in the ability to provide highly specific molecular contrast of pigmented and non-pigmented samples. A theoretical framework is described, and experimental results and simulations illustrate the potential of this method. Implications for biomedical imaging are discussed.

Duke Scholars

Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

April 2013

Volume

21

Issue

8

Start / End Page

9353 / 9364

Related Subject Headings

  • Spectrum Analysis
  • Optics
  • Nonlinear Dynamics
  • Molecular Imaging
  • Microscopy
  • Equipment Failure Analysis
  • Equipment Design
  • Computer-Aided Design
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
 

Citation

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Robles, F. E., Samineni, P., Wilson, J. W., & Warren, W. S. (2013). Pump-probe nonlinear phase dispersion spectroscopy. Optics Express, 21(8), 9353–9364. https://doi.org/10.1364/oe.21.009353
Robles, Francisco E., Prathyush Samineni, Jesse W. Wilson, and Warren S. Warren. “Pump-probe nonlinear phase dispersion spectroscopy.Optics Express 21, no. 8 (April 2013): 9353–64. https://doi.org/10.1364/oe.21.009353.
Robles FE, Samineni P, Wilson JW, Warren WS. Pump-probe nonlinear phase dispersion spectroscopy. Optics express. 2013 Apr;21(8):9353–64.
Robles, Francisco E., et al. “Pump-probe nonlinear phase dispersion spectroscopy.Optics Express, vol. 21, no. 8, Apr. 2013, pp. 9353–64. Epmc, doi:10.1364/oe.21.009353.
Robles FE, Samineni P, Wilson JW, Warren WS. Pump-probe nonlinear phase dispersion spectroscopy. Optics express. 2013 Apr;21(8):9353–9364.
Journal cover image

Published In

Optics express

DOI

EISSN

1094-4087

ISSN

1094-4087

Publication Date

April 2013

Volume

21

Issue

8

Start / End Page

9353 / 9364

Related Subject Headings

  • Spectrum Analysis
  • Optics
  • Nonlinear Dynamics
  • Molecular Imaging
  • Microscopy
  • Equipment Failure Analysis
  • Equipment Design
  • Computer-Aided Design
  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware