Pump-probe nonlinear phase dispersion spectroscopy.
Pump-probe microscopy is an imaging technique that delivers molecular contrast of pigmented samples. Here, we introduce pump-probe nonlinear phase dispersion spectroscopy (PP-NLDS), a method that leverages pump-probe microscopy and spectral-domain interferometry to ascertain information from dispersive and resonant nonlinear effects. PP-NLDS extends the information content to four dimensions (phase, amplitude, wavelength, and pump-probe time-delay) that yield unique insight into a wider range of nonlinear interactions compared to conventional methods. This results in the ability to provide highly specific molecular contrast of pigmented and non-pigmented samples. A theoretical framework is described, and experimental results and simulations illustrate the potential of this method. Implications for biomedical imaging are discussed.
Duke Scholars
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Related Subject Headings
- Spectrum Analysis
- Optics
- Nonlinear Dynamics
- Molecular Imaging
- Microscopy
- Equipment Failure Analysis
- Equipment Design
- Computer-Aided Design
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Spectrum Analysis
- Optics
- Nonlinear Dynamics
- Molecular Imaging
- Microscopy
- Equipment Failure Analysis
- Equipment Design
- Computer-Aided Design
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware