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Determining γδ versus αß T cell development.

Publication ,  Journal Article
Ciofani, M; Zúñiga-Pflücker, JC
Published in: Nat Rev Immunol
September 2010

The thymus produces several types of functionally distinct T cell subsets. However, at a more fundamental level only two genetically distinct T cell lineages exist: the γδ and αß T cell lineages. Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation. Here, we highlight recent findings that have helped to provide important clues to the mechanisms that underpin the generation of γδ T cells in the mouse thymus.

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

September 2010

Volume

10

Issue

9

Start / End Page

657 / 663

Location

England

Related Subject Headings

  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Mice
  • Immunology
  • Cell Lineage
  • Cell Differentiation
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Ciofani, M., & Zúñiga-Pflücker, J. C. (2010). Determining γδ versus αß T cell development. Nat Rev Immunol, 10(9), 657–663. https://doi.org/10.1038/nri2820
Ciofani, Maria, and Juan Carlos Zúñiga-Pflücker. “Determining γδ versus αß T cell development.Nat Rev Immunol 10, no. 9 (September 2010): 657–63. https://doi.org/10.1038/nri2820.
Ciofani M, Zúñiga-Pflücker JC. Determining γδ versus αß T cell development. Nat Rev Immunol. 2010 Sep;10(9):657–63.
Ciofani, Maria, and Juan Carlos Zúñiga-Pflücker. “Determining γδ versus αß T cell development.Nat Rev Immunol, vol. 10, no. 9, Sept. 2010, pp. 657–63. Pubmed, doi:10.1038/nri2820.
Ciofani M, Zúñiga-Pflücker JC. Determining γδ versus αß T cell development. Nat Rev Immunol. 2010 Sep;10(9):657–663.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

September 2010

Volume

10

Issue

9

Start / End Page

657 / 663

Location

England

Related Subject Headings

  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Mice
  • Immunology
  • Cell Lineage
  • Cell Differentiation
  • Animals
  • 3204 Immunology
  • 1107 Immunology