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Adam Silverstein

Biostatistician, Principal
Duke Clinical Research Institute
300 West Morgan Street, 4th Floor - Statistics, Durham, NC 27701
300 West Morgan Street, 4th Floor - Statistics, Durham, NC 27705

Current Appointments & Affiliations


Recent Publications


Evaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial.

Journal Article JAMA Neurol · January 1, 2026 IMPORTANCE: Treatment for cognitive dysfunction due to postacute sequelae of long COVID (ie, symptoms of fatigue, malaise, weakness, confusion that persist beyond 12 weeks after an initial COVID infection) remains a significant unmet need. OBJECTIVE: To te ... Full text Link to item Cite

RECOVER-NEURO: study protocol for a multi-center, multi-arm, phase 2, randomized, active comparator trial evaluating three interventions for cognitive dysfunction in post-acute sequelae of SARS-CoV-2 infection (PASC).

Journal Article Trials · May 17, 2024 BACKGROUND: Post-acute sequelae of SARS-CoV-2 infection (PASC) symptoms have broad impact, and may affect individuals regardless of COVID-19 severity, socioeconomic status, race, ethnicity, or age. A prominent PASC symptom is cognitive dysfunction, colloqu ... Full text Open Access Link to item Cite

Prognostic Impact of Sinus Rhythm in Atrial Fibrillation Patients: Separating Rhythm Outcomes From Randomized Strategy Findings From the CABANA Trial.

Journal Article Circ Arrhythm Electrophysiol · May 2024 BACKGROUND: Clinically detected atrial fibrillation (AF) is associated with a significant increase in mortality and other adverse cardiovascular events. Since the advent of effective methods for AF rhythm control, investigators have attempted to determine ... Full text Open Access Link to item Cite
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Recent Grants


Physiologically-Based Pharmacokinetic Models for Optimal Drug Dosing in Children

Clinical TrialSenior Statistician · Awarded by National Institutes of Health · 2014 - 2020

SOLI - Solithromycin Pediatric Development Program (Phase 2/3)- Labor & Sub Cost

Clinical TrialStatistician · Awarded by Cempra Pharmaceuticals, Inc. · 2016 - 2018

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